Associations of risk factors in childhood with arterial stiffness 26 years later

Chu, Chao; Dai, Yi; Mu, Jianjun; Yang, Ruihai; Wang, Man; Yang, Jun; Ren, Yazhou; Xie, Bingqing; Dong, Zhenzhen; Yang, Fan; Wang, Dan; Yan, Ding-Yi; Guo, Tongshuai; Wang, Yan

doi:10.1097/hjh.0000000000001242

Cited by 43 publications

(54 citation statements)

References 28 publications

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“…The study began in 1987 when 4623 schoolchildren were enrolled from 26 rural sites of three towns (Qili, Laojun, and Shayan) in Hanzhong, Shaanxi, China. 13 During baseline evaluation, the inclusion criteria were as follows: aged 6-15 years old in 1987, no chronic disease in the child's medical history, and can communicate normally in Mandarin. Later information collection was conducted in 1989,1992,1995,2005,2013, and 2017, resulting in a maximum follow-up time of 30 years.…”

Section: Study Populationmentioning

confidence: 99%

Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age

Zheng

Chu

et al. 2018

JASN

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Background Although high BP is one of the most important factors affecting renal function, whether longitudinal BP trajectories in early life course are associated with renal function damage in later life is unclear.Methods To investigate the correlation between BP trajectories from childhood to adulthood and renal function in middle age, we used group-based trajectory models to identify BP trajectories in 2430 individuals (aged 6-15 years old at baseline) participating in the ongoing Hanzhong Adolescent Hypertension Cohort. We tested the association between these trajectories and subclinical renal damage in middle age, adjusting for several covariates. ResultsWe identified four distinct systolic BP trajectories among 2430 subjects: low stable, moderate stable, high stable, and moderate increasing on the basis of systolic BP levels at baseline and during the 30-year follow-up period. The urinary albumin-to-creatinine ratio (uACR) was higher in moderate stable, high stable, and moderate increasing groups compared with the low stable group. A total of 228 individuals had subclinical renal disease by 2017. Compared with the low stable trajectory group, the other groups had increasingly greater odds of experiencing subclinical renal disease in middle age. These associations were not altered after adjustment for other covariates, except for in the moderate stable group. Analyzed results were similar for the mean arterial pressure and diastolic BP trajectory groups.Conclusions Higher BP trajectories were correlated with higher of uACR levels and risk of subclinical renal disease in middle age. Identifying long-term BP trajectories from early age may assist in predicting individuals' renal function in later life.

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Section: Study Populationmentioning

confidence: 99%

Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age

Zheng

Chu

et al. 2018

JASN

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“…These pathologic alterations support Folkow’s hypothesis that elevated BP thickens the medial layer of the vessels which be-gets hypertension [158•]. Furthermore, these linked with BP tracking in children in which BP during childhood predicts adult blood BP [4, 8–10, 11•]. Therefore, there is a need for early monitoring and treatment of pediatric hypertension such as ambulatory BP monitoring and pharmacologic and non-pharmacologic management of elevated BP [159].…”

Section: Pathogenesis Of Primary Pediatric Hypertensionmentioning

confidence: 60%

“…Indeed, the predictive value of childhood hypertension for adult hypertension has been estimated to vary from 19 to 65% [5, 8]. Nevertheless, there is some predictability of adult BP from childhood values and juvenile target organ damage, which includes left ventricular hypertrophy, carotid intima-media thickening, and decreased neurocognitive performance and brachial flow-mediated dilation [9, 10, 11•]. Higher systolic BP in male children and adolescents with a family history of hypertension increases the risk of developing long-term arterial stiffness, determined by brachial-ankle pulse wave velocity [11•].…”

Section: Introductionmentioning

confidence: 99%

Primary Pediatric Hypertension: Current Understanding and Emerging Concepts

et al. 2017

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The rising prevalence of primary pediatric hypertension and its tracking into adult hypertension point to the importance of determining its pathogenesis to gain insights into its current and emerging management. Considering that the intricate control of BP is governed by a myriad of anatomical, molecular biological, biochemical, and physiological systems, multiple genes are likely to influence an individual's BP and susceptibility to develop hypertension. The long-term regulation of BP rests on renal and non-renal mechanisms. One renal mechanism relates to sodium transport. The impaired renal sodium handling in primary hypertension and salt sensitivity may be caused by aberrant counter-regulatory natriuretic and anti-natriuretic pathways. The sympathetic nervous and renin-angiotensin-aldosterone systems are examples of antinatriuretic pathways. An important counter-regulatory natriuretic pathway is afforded by the renal autocrine/paracrine dopamine system, aberrations of which are involved in the pathogenesis of hypertension, including that associated with obesity. We present updates on the complex interactions of these two systems with dietary salt intake in relation to obesity, insulin resistance, inflammation, and oxidative stress. We review how insults during pregnancy such as maternal and paternal malnutrition, glucocorticoid exposure, infection, placental insufficiency, and treatments during the neonatal period have long-lasting effects in the regulation of renal function and BP. Moreover, these effects have sex differences. There is a need for early diagnosis, frequent monitoring, and timely management due to increasing evidence of premature target organ damage. Large controlled studies are needed to evaluate the long-term consequences of the treatment of elevated BP during childhood, especially to establish the validity of the current definition and treatment of pediatric hypertension.

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“…Therefore, it is advisable to intensify the implementation of the system of diagnostic screening for the timely detection of early vascular aging by the type of EVA syndrome among young adults. The same approach is shared by Chinese researchers who performed a 26-year prospective study of vascular stiffness parameters in terms of the shoulder-ankle index at 4623 school pupils aged 6-15 years living in one of the industrialized areas of China [4]. The authors also emphasize the greater propensity of the vascular wall to the accelerated aging in boys compared to girls.…”

Section: ключевые слова: сосудистая ригидность молодой возрастmentioning

confidence: 98%

The place of evaluation vascular rigidity in process of student’s health screening

Evgenyevna¹,

Nikolaevna²,

Vladimirovich³

et al. 2017

Medical news of the North Caucasus

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Волгоградский государственный медицинский университет, Российская ФедерацияQuestionnaire of 120 sports medicine physicians is to ascertain sports medicine doctors' views on athlete healthcare issues. Insufficient medical coverage provided for athletes (25.0 % of respondents underlined its insufficiency, 43.4 % respondents pointed out some lacks in it); ex-athlete regular medical check-up problems (49.2 % of respon-

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Associations of risk factors in childhood with arterial stiffness 26 years later

Abstract: Higher SBP in children and adolescents, family history of hypertension, and male sex may increase the risk of developing long-term arterial stiffness.

Cited by 43 publications

References 28 publications

Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age

Association of Blood Pressure Trajectories in Early Life with Subclinical Renal Damage in Middle Age

Primary Pediatric Hypertension: Current Understanding and Emerging Concepts

The place of evaluation vascular rigidity in process of student’s health screening

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