Associations of Resting-State fMRI Functional Connectivity with Flow-BOLD Coupling and Regional Vasculature

Tak, Sungho; Polimeni, Jon̈athan R.; Wang, Danny J.J.; Yan, Lirong; Chen, Jean

doi:10.1089/brain.2014.0299

Cited by 55 publications

(56 citation statements)

References 49 publications

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“…A similar finding was also reported in another study of humans (Tak et al, 2015). Our finding of decrease in both DMN and CBF of PCC is consistent with that reported in prior studies.…”

Section: Long-duration Effect Of Isoflurane On Dmn Of the Brainsupporting

confidence: 93%

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Zhang

2017

Brain Connectivity

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Isoflurane is an inhalational anesthetic that is widely used in medical procedures or biomedical research. The duration of anesthesia administration varies from minutes to hours. It is known that isoflurane has dosedependent effects on brain functionality and physiology, and long-duration anesthesia administration could cause neurocognitive decline in animals and humans. However, the duration effect of isoflurane on the brain physiology and functionality still remains poorly understood. In the present study, cerebral blood flow (CBF) and functional connectivity of adult rhesus monkeys (maintained with 1% isoflurane for 4 h) were examined by using magnetic resonance imaging. The results demonstrate that long-duration isoflurane exposure could result in CBF reduction in most brain areas and functional connectivity decrease in the dominant default-mode network. This study reveals the anesthetic duration effects in the central nervous system of anesthetized subjects and suggests that such duration effects should be considered in examining the brain function of anesthetized animals or humans with contemporary neuroimaging approaches.

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“…A similar finding was also reported in another study of humans (Tak et al, 2015). Our finding of decrease in both DMN and CBF of PCC is consistent with that reported in prior studies.…”

Section: Long-duration Effect Of Isoflurane On Dmn Of the Brainsupporting

confidence: 93%

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Zhang

2017

Brain Connectivity

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“…Underlying vascular heterogeneity might induce false-positive or -negative spatial correlations, however. In the resting state fMRI literature, the influence of cerebral blood flow (CBF) and vessel size on BOLD-FC is increasingly discussed (45), and recent studies suggest strong BOLD-CBF coupling (46,47). There is also evidence that these CBF fluctuations indicate reactivity to neuronal activity rather than to heterogeneous vascularity, however.…”

Section: Discussionmentioning

confidence: 99%

“…There is also evidence that these CBF fluctuations indicate reactivity to neuronal activity rather than to heterogeneous vascularity, however. Tak et al (46) also acquired data on large-vessel volume fraction and found that BOLD-FC was inversely related to macrovascular volume fraction. The stronger relationship with small-to medium-sized vessels (closer to neuronal activity) was particularly prominent for major FC hubs.…”

Section: Discussionmentioning

confidence: 99%

Metabolic connectivity mapping reveals effective connectivity in the resting human brain

Riedl

Utz

Castrillón

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

103

105

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Directionality of signaling among brain regions provides essential information about human cognition and disease states. Assessing such effective connectivity (EC) across brain states using functional magnetic resonance imaging (fMRI) alone has proven difficult, however. We propose a novel measure of EC, termed metabolic connectivity mapping (MCM), that integrates undirected functional connectivity (FC) with local energy metabolism from fMRI and positron emission tomography (PET) data acquired simultaneously. This method is based on the concept that most energy required for neuronal communication is consumed postsynaptically, i.e., at the target neurons. We investigated MCM and possible changes in EC within the physiological range using “eyes open” versus “eyes closed” conditions in healthy subjects. Independent of condition, MCM reliably detected stable and bidirectional communication between early and higher visual regions. Moreover, we found stable top-down signaling from a frontoparietal network including frontal eye fields. In contrast, we found additional top-down signaling from all major clusters of the salience network to early visual cortex only in the eyes open condition. MCM revealed consistent bidirectional and unidirectional signaling across the entire cortex, along with prominent changes in network interactions across two simple brain states. We propose MCM as a novel approach for inferring EC from neuronal energy metabolism that is ideally suited to study signaling hierarchies in the brain and their defects in brain disorders.

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“…[ Figure 7] Tak and colleagues' subsequent work took the CBF-BOLD coupling analysis one step further to examine the relationship between the degree of coupling and the corresponding functional connectivity measurements (Tak et al, 2015). The analysis demonstrated that restingstate functional connectivity strength, in this case based on the BOLD signal, is stronger in regions of stronger CBF-BOLD coupling (Figure 8).…”

Section: Assessment Of Resting-state Neurovacular Physiologymentioning

confidence: 99%

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

2015

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Arterial spin labeling (ASL) is an increasingly established magnetic resonance imaging (MRI) technique that is finding broader applications in studying the healthy and diseased brain. This review addresses the use of ASL to assess brain function in the resting state. Following a brief technical description, we discuss the use of ASL in the following main categories: (1) resting-state functional connectivity (FC) measurement: the use of ASL-based cerebral blood flow (CBF) measurements as an alternative to the blood oxygen level-dependent (BOLD) technique to assess resting-state FC; (2) the link between network CBF and FC measurements: the use of network CBF as a surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using ASL to assess dynamic CBF-BOLD coupling and oxidative metabolism in the resting state. In addition, we summarize some future challenges and interesting research directions for ASL, including slice-accelerated (multiband) imaging as well as the effects of motion and other physiological confounds on perfusion-based FC measurement. In summary, this work reviews the state-of-the-art of ASL and establishes it as an increasingly viable MRI technique with high translational value in studying resting-state brain function.

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Associations of Resting-State fMRI Functional Connectivity with Flow-BOLD Coupling and Regional Vasculature

Cited by 55 publications

References 49 publications

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys

Metabolic connectivity mapping reveals effective connectivity in the resting human brain

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

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