Associations of residential and occupational history with the distribution of persistent pollutant mixtures in adipose tissue samples

Echeverría, Ruth; Vrhovnik, Petra; Salcedo‐Bellido, Inmaculada; Pérez-Carrascosa, Francisco Miguel; Gómez-Peña, Celia; Fiket, Željka; Martín‐Olmedo, Piedad; Olea, Nicolás; Fernández, Mariana F.; Arrebola, Juan Pedro

doi:10.1016/j.envres.2020.110687

Cited by 7 publications

(7 citation statements)

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“…To date, only one publication has reported elevated levels of phthalates among current users of vaginal contraceptive rings [ 22 ]. Confounding factors, such as educational level, social class, occupational history, and lifestyle habits, may play a role and have been shown to be associated with TEXB-α levels [ 8 , 16 , 23 , 24 ]. In this study, we did not examine these possible confounding variables.…”

Section: Discussionmentioning

confidence: 99%

Xenoestrogen concentration in women with endometriosis or leiomyomas: A case-control study

Valdes-Devesa,

Sanz-Rosa,

Thuissard-Vasallo

et al. 2024

PLoS ONE

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Background Xenoestrogens are synthetic or naturally occurring chemicals capable of altering the endocrine system of humans and animals owing to their molecular similarity to endogenous hormones. There is limited data regarding their effects on women´s health. Chronic exposure to xenoestrogens can promote the development of estrogen-related diseases. Objectives To examine xenoestrogen concentration (TEXB-α) differences between women with leiomyomas or endometriosis and control women, and to study the relationship between the clinical and sociodemographic characteristics of these patients and their xenoestrogen levels. Methods Prospective case-control study. We selected 221 women who underwent surgery at Quironsalud Madrid University Hospital between 2017 and 2021. The cases included 117 patients: 74 women who underwent surgery for uterine leiomyomas, 21 with endometriosis, and 22 with both pathologies. The control group comprised 104 healthy women who underwent surgical procedures for other reasons. TEXB-α was determined in the omental fat of all patients. Using a questionnaire and reviewing the patients’ medical records, we collected sociodemographic data and other relevant variables. Results A significant majority of study participants (68.8%) had detectable levels of xenoestrogens. We found no association between TEXB-α levels in omental fat and the presence of myomas or endometriosis. In the case group, women living or working in Madrid Community exhibited, on average, 3.12 Eeq pM/g higher levels of TEXB-α compared to those working in other areas (p = 0.030). Women who referred to the use of estrogen-containing hormonal contraceptives had, on average, 3.02 Eeq pM/g higher levels of TEXB-α than those who had never used them (p = 0.022). Conclusions This study found no association between omental xenoestrogen levels and leiomyomas or endometriosis. However, their presence in most participants and their association with highly polluted areas emphasizes the importance of limiting environmental exposure to these substances. We also identified an association between hormonal contraceptive use and xenoestrogen concentration.

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Section: Discussionmentioning

confidence: 99%

Xenoestrogen concentration in women with endometriosis or leiomyomas: A case-control study

Valdes-Devesa,

Sanz-Rosa,

Thuissard-Vasallo

et al. 2024

PLoS ONE

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“…Adipose tissue samples were collected from pelvic waist (50%), front abdominal wall (40%), and limbs (10%). A wider description of the GraMo cohort methodology, including characterization of other exposures, has been reported elsewhere [ 4 , 22 , 37 , 38 ].…”

Section: Methodsmentioning

confidence: 99%

“…The sub-areas (Alhama, Baza, and Valle de Lecrín) with ≤6 participants were excluded from the analysis. Later, the residence was recategorized in the following 3 areas: (1) Motril city and coast region and both areas in the Mediterranean coast, with large agriculture zones and greenhouses where the use of pesticides is higher; (2) Granada city and Granada Metropolitan Area, as both are urban areas with a high amount of traffic and whose main economic activity is based on industry and tourism; (3) Poniente and Alpujarras, both rural areas with less population and an agricultural tradition [ 4 ] ( Figure 1 ). Thus, the total pesticide use in Granada province over recruitment (years 2003 and 2004) remained virtually constant (1953.03 and 2053.73 tons, respectively) [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

“…This continuous exposure might pose relevant risks to human health, since POP exposure is suspected to increase the risk of certain chronic and highly prevalent conditions, e.g., type 2 diabetes, cardiovascular disease, or cancer [ 3 ]. POPs include diverse chemical groups such as Polychlorinated Biphenyls (PCBs), which have been used in industrial applications, and Organochlorine Pesticides (OCPs) used in agriculture [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Salcedo‐Bellido

Amaya

Pérez-Díaz

et al. 2022

IJERPH

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To identify bioaccumulation patterns of α-, β- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors, adipose tissue samples of 387 subjects from GraMo cohort in Southern Spain were analyzed. Potential predictors of these organochlorine pesticides (OCP) levels were collected by face-to-face interviews and assessed by multivariable linear and logistic regression. OCPs were detected in 84.2% (β-HCH), 21.7% (α-HCH), and 19.6% (dicofol) of the population. β-HCH levels were positively related to age, body mass index (BMI), mother’s occupation in agriculture during pregnancy, living in Poniente and Alpujarras, white fish, milk and water consumption, and negatively related to being male, living near to an agricultural area, working ≥10 years in agriculture, and beer consumption. Detectable α-HCH levels were positively related to age, BMI, milk consumption, mother’s occupation in agriculture during pregnancy, and negatively with residence in Poniente and Alpujarras, Granada city, and Granada Metropolitan Area. Residence near to an agricultural area, smoking habit, white fish and water consumption, and living in Poniente and Alpujarras, Granada city and Granada Metropolitan Area were negatively associated with detectable dicofol levels. Our study revealed different bioaccumulation patterns of α, β-HCH and dicofol, probably due to their dissimilar period of use, and emphasize the need for assessing the exposure to frequently overlooked pollutants.

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“…To date, only one publication has reported elevated levels of phthalates among current users of vaginal contraceptive rings [22]. Confounding factors, such as educational level, social class, occupational history, and lifestyle habits, may play a role and have been shown to be associated with TEXBα levels [8,16,23,24]. In this study, we did not examine these possible confounding variables.…”

Section: Plos Onementioning

confidence: 90%

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Associations of residential and occupational history with the distribution of persistent pollutant mixtures in adipose tissue samples

Cited by 7 publications

References 58 publications

Xenoestrogen concentration in women with endometriosis or leiomyomas: A case-control study

Xenoestrogen concentration in women with endometriosis or leiomyomas: A case-control study

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

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