Associations of Regional and Network Functional Connectivity With Exercise-Induced Low Back Pain

Bush, Nicholas J; Schneider, Victor J.; Sevel, Landrew S.; Bishop, Mark D.; Boissoneault, Jeff

doi:10.1016/j.jpain.2021.05.004

Cited by 9 publications

(9 citation statements)

References 52 publications

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“…The left superior parietal lobule has been reliably implicated structurally and functionally in expectancy‐enhanced placebo manipulation (Atlas & Wager, 2014; Cherkasova et al, 2022; Makary et al, 2018; Schnitzer et al, 2018). Further, this finding replicates previous work that found that increased left middle frontal gyrus and left superior parietal lobule FC was associated with lower delayed onset muscle soreness (Bush et al, 2021). Together, both the left middle frontal gyrus and left superior parietal lobule have been found to be independently associated with PA and their functional correlation is associated with lower pain intensity.…”

Section: Discussionsupporting

confidence: 90%

Task‐dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain‐free individuals

Bush

Boissoneault

Letzen

et al. 2023

European Journal of Pain

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BackgroundTask‐based functional connectivity (FC) of pain‐related regions resulting from expectancy‐based placebo induction has yet to be examined, limiting our understanding of regions and networks associated with placebo analgesia.MethodsFifty‐five healthy pain‐free adults over 18 (M = 22.8 years, SD = 7.75) were recruited (65.5% women; 63.6% non‐Hispanic/Latino/a/x; 58.2% White). Participants completed a baseline followed by a placebo session involving the topical application of an inactive cream in the context of an expectancy‐enhancing instruction set. Noxious heat stimuli were applied to the thenar eminence of the right palm using an fMRI‐safe thermode. Stimulus intensity was individually calibrated to produce pain ratings of approximately 40 on a 100‐point visual analogue scale.ResultsA total of 67.3% of the participants showed a reduction in pain intensity in the placebo condition with an average reduction in pain across the whole sample of 12.7%. Expected pain intensity was associated with reported pain intensity in the placebo session (b = 0.32, p = 0.004, R2 = 0.15). Voxel‐wise analyses indicated seven clusters with significant activation during noxious heat stimulation at baseline (pFDR < 0.05). Generalized psychophysiological interaction analysis suggested that placebo‐related FC changes between middle frontal gyrus‐superior parietal lobule during noxious stimulation were significantly associated with the magnitude of pain reduction (pFDR < 0.05).ConclusionsResults suggest that stronger expectancy‐based placebo responses might be underpinned by greater FC among attentional and somatosensory regions.SignificanceThis article provides support and insight for task‐dependent functional connectivity differences related to the magnitude of placebo analgesia. Our findings provide key support that the magnitude of expectation‐based placebo response depends on the coupling of regions associated with somatosensory and attentional processing.

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Section: Discussionsupporting

confidence: 90%

Task‐dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain‐free individuals

Bush

Boissoneault

Letzen

et al. 2023

European Journal of Pain

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“…Previous neuroimaging study identified that migraine patients had cortical thinning in several brain regions, including the left middle frontal gyrus, and the frequency and duration of symptom were related to the cortical thickness of sensorimotor cortex and middle frontal gyrus [23,24]. In addition, exercise-induced low back pain and labor pain experiences were found to be correlated with brain networks including the left middle frontal gyrus [25,26]. Therefore, we reasoned that POPP might induce functional changes in the left middle frontal gyrus.…”

Section: Discussionmentioning

confidence: 98%

Association between aberrant brain activity and pain in patients with primary osteoporotic pain: a resting-state fMRI study

Guo

Yang

et al. 2023

Preprint

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Introduction: Primary osteoporotic pain (POPP) seriously affects the life of patients. Although chronic pain is associated with altered central nervous activity, the central pathological mechanism of POPP is still unclear. This study aimed to explore the differences of brain activity between POPP patients and healthy controls (HCs), as well as the correlations between altered brain regions and pain. Method: Magnetic resonance imaging data (MRI) and visual analogue scale (VAS) scores of subjects were collected. MRI data were preprocessed and then regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) values of brain regions were calculated. ReHo and ALFF values were compared between groups. Result: (1) Compared with HCs, reduced ReHo values were found in the left medial superior frontal gyrus, middle frontal gyrus, opercular part of inferior frontal gyrus and right dorsolateral superior frontal gyrus of POPP patients. (2) Reduced ALFF values were identified in the left dorsolateral superior frontal gyrus, medial superior frontal gyrus, orbital part of middle frontal gyrus, opercular part of inferior frontal gyrus and right dorsolateral superior frontal gyrus. (3) Negative correlations were identified between ReHo values of the left middle frontal gyrus and VAS scores in the patient group. Conclusion：The prefrontal dysfunction may be related to the occurrence of POPP. In addition, the left middle frontal gyrus can be used as an indicator to evaluate the severity of pain in patients with POPP. These findings help us to further understand the pathogenesis of POPP from the perspective of neuroimaging.

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“…One study have found that visceral pain was associated with the hippocampus, fusiform gyrus, striatum, occipital cortex, insula, and amygdala ( Schmidt et al, 2022 ). Furthermore, there is growing evidence that the visual cortex has also been involved in the processing of pain signals ( Liu et al, 2019 ; Wei et al, 2019 ; Bush et al, 2021 ). We compared the alterations of lingual gyri in LDH-pre and HCs, LDH-pre and LDH-pos respectively, and the results presented that both ALFF and fALFF in right lingual gyri were sensitive to SMT treatments in conventional and slow-4 bands.…”

Section: Discussionmentioning

confidence: 99%

A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study

et al. 2022

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PurposeLumbar disc herniation (LDH) is one of the leading causes of low-back pain and results in a series of clinical symptoms, including pain, reflex loss, and muscle weakness. Spinal manipulative therapy (SMT) can relieve pain and promote internal and external stabilization of the lumbar spine. In this study, we investigated whether the brain alterations of LDH patients with SMT were frequency-dependent based on the calculation of Amplitude of Low-Frequency Fluctuations (ALFF) and fractional ALFF (fALFF). Further, we established a cohort of LDH patients to evaluate the contribution of SMT treatments to brain functional reorganization.MethodsA total of 55 participants, including 27 LDH patients and 28 health controls (HCs), were collected. All LDH patients underwent two fMRI scans (before SMT and after the sixth SMT session). To represent LDH-related brain oscillatory activities, we calculated the ALFF and fALFF in the conventional band (0.01–0.08 Hz), the slow-4 band (0.027–0.073 Hz), and the slow-5 band (0.01–0.027 Hz). Moreover, we extracted ALFF and fALFF values in clusters with significant differences to evaluate the SMT effect.ResultsCompared with HCs, the LDH patients before SMT (LDH-pre) exhibited increased fALFF in right lingual gyri in the conventional band, and showed increased fALFF in left Cerebelum_Crus1 in the slow-4 band. We further examined the abnormal brain activities changes before and after the SMT intervention. The ALFF and fALFF values of LDH-pre group were higher than those of the HCs and LDH-pos groups. After SMT, the increased ALFF and fALFF values were suppressed for patients in conventional band and slow-4 band.ConclusionThe present study characterized the altered regional patterns in spontaneous neural activity in patients with LDH. Meanwhile, SMT is an effective treatment of LDH, and we supposed that it might have been involved in modulating dysfunctional brain regions which are important for the processing of pain. The findings of the current study may provide new insights to understand pathological mechanism of LDH.

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Associations of Regional and Network Functional Connectivity With Exercise-Induced Low Back Pain

Cited by 9 publications

References 52 publications

Task‐dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain‐free individuals

Task‐dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain‐free individuals

Association between aberrant brain activity and pain in patients with primary osteoporotic pain: a resting-state fMRI study

A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study

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