Associations of Reading Efficiency with White Matter Properties of the Cerebellar Peduncles in Children

Bruckert, Lisa; Travis, Katherine E.; Mezer, Aviv; Ben-Shachar, Michal; Feldman, Heidi M.

doi:10.1007/s12311-020-01162-2

Cited by 19 publications

(25 citation statements)

References 33 publications

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“…Prematurely born children demonstrate elevated rates of SPD (Wickremasinghe et al, 2013 ) and are known to have WM diffusivity changes on DTI that are characteristic of diminished myelination (i.e., elevated RD and MD as well as reduced FA) similar to those we demonstrate herein for the cerebellar and cerebral peduncles in term-born children with SPD. A new study of neurotypical children has shown a strong correlation between FA in the right and left SCP and quantitative T1 values, a more specific measure of myelination than DTI metrics, providing further support that our findings are at least in part due to myelination differences between groups (Bruckert et al, 2020 ). Thus, abnormal excitatory-inhibitory balance during cerebellar development may represent a possible mechanism for producing these microstructural WM alterations that are ultimately expressed as the SPD phenotype.…”

Section: Discussionsupporting

confidence: 81%

“…model of white matter injury of prematurity shows a loss of GABA A receptor-mediated synaptic input to cerebellar NG2 cells, resulting in extensive proliferation of these cells and delayed oligodendrocyte maturation, eventually leading to dysmyelination (Zonouzi et al, 2015). Prematurely born children demonstrate elevated rates of SPD (Wickremasinghe a more specific measure of myelination than DTI metrics, providing further support that our findings are at least in part due to myelination differences between groups (Bruckert et al, 2020). Thus, abnormal excitatory-inhibitory balance during cerebellar development may represent a possible mechanism for producing these microstructural WM alterations that are ultimately expressed as the SPD phenotype.…”

Section: Alterations Of Brainstem and Cerebellar White Matter Microstructure In Spdsupporting

confidence: 72%

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Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention

et al. 2021

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Sensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD (n = 42) and typically developing controls (TDC; n = 39) were compared for fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) across the following cerebellar tracts: the middle cerebellar peduncles (MCP), superior cerebellar peduncles (SCP), and cerebral peduncles (CP). Compared to TDC, children with SPD show reduced microstructural integrity of the SCP and MCP, characterized by reduced FA and increased MD and RD, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals.

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Section: Discussionsupporting

confidence: 81%

Section: Alterations Of Brainstem and Cerebellar White Matter Microstructure In Spdsupporting

confidence: 72%

Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Prematurely born children demonstrate elevated rates of SPD (Wickremasinghe et al 2013) and are known to have WM diffusivity changes on DTI that are characteristic of diminished myelination (i.e., elevated RD and MD as well as reduced FA) similar to those we demonstrate herein for the cerebellar and cerebral peduncles in term-born children with SPD. A new study of neurotypical children has shown a strong correlation between FA in the right and left SCP and quantitative T1 values, a more specific measure of myelination than DTI metrics, providing further support that our findings are at least in part due to myelination differences between groups (Bruckert et al 2020). Thus, abnormal excitatory-inhibitory balance during cerebellar development may represent a possible mechanism for producing these microstructural WM alterations that are ultimately expressed as the SPD phenotype.…”

Section: Discussionsupporting

confidence: 79%

Altered cerebellar white matter in sensory processing dysfunction is associated with impaired multisensory integration and attention

Narayan

Rowe

Palacios

et al. 2020

Preprint

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Sensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD (n=42) and typically developing controls (TDC; n=39) were compared for fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) across the following cerebellar tracts: the middle cerebellar peduncles (MCP), superior cerebellar peduncles (SCP), and cerebral peduncles (CP). Compared to TDC, children with SPD show reduced microstructural integrity of the SCP and MCP, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals.

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“…Developmental changes in R1 suggest that this metric reflects myelin content (Yeatman et al, 2014). Our team has reported that values of R1 in the cerebellar peduncles were related to reading abilities in FT children (Bruckert et al, 2020). A recent study showed, however, that two brain imaging metrics of myelin content in cerebral tracts were associated with age but not with reading abilities in typically developing FT children (Geeraert et al, 2020).…”

Section: Introductionmentioning

confidence: 97%

White matter properties underlying reading abilities differ in 8-year-old children born full term and preterm

Brignoni-Pérez¹,

Dubner²,

Ben-Shachar³

et al. 2021

Preprint

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Diffusion magnetic resonance imaging (dMRI) studies find differences in associations between reading and white matter fractional anisotropy (FA) in children born full term (FT) versus preterm (PT). Use of complementary neuroimaging modalities may reveal neurobiological factors driving these associations. We used two MRI methods to interpret associations of reading abilities and white matter properties in FT and PT children. Participants (N=79; 36 FT; 43 PT) were administered Gray’s Oral Reading Test at age 8 years. We segmented two dorsal and two ventral white matter tracts associated with reading skills and quantified (1) FA from dMRI and (2) R1 from quantitative relaxometry, as a proxy for myelin content. We examined correlations between reading scores and imaging metrics, assessing trajectories along the tracts. Mean reading scores fell in the typical range in both groups. Reading positively correlated with FA in segments of the left arcuate and the left and right superior longitudinal fasciculi, but only in FT children, not in PT children. Reading positively correlated with R1 in segments of the left superior longitudinal, right uncinate, and left inferior longitudinal fasciculi, but only in PT children, not in FT children. The significantly different patterns of associations between reading abilities and white matter properties across FT and PT groups suggest variations in the neurobiology of typical reading abilities.

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Associations of Reading Efficiency with White Matter Properties of the Cerebellar Peduncles in Children

Cited by 19 publications

References 33 publications

Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention

Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention

Altered cerebellar white matter in sensory processing dysfunction is associated with impaired multisensory integration and attention

White matter properties underlying reading abilities differ in 8-year-old children born full term and preterm

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