Associations of Reactive Thrombocytosis With Clinical Characteristics in Pediatric Diseases

Wang, Jinn-Li; Huang, Liang; Wu, Kuan Hsun; Lin, Hui Wen; Ho, Man Yan; Liu, Hsingjin Eugene

doi:10.1016/j.pedneo.2011.06.004

Cited by 21 publications

(26 citation statements)

References 19 publications

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“…Normally, reactive thrombocytosis does not entail a greater risk of thromboembolic events or haemorrhagic complications. 7 On the other hand, in primary forms, this activation is symptomatic in up to 25---40% of patients. 2,5 In our patient, the episodes of headache and abdominal pain may have been related to the extreme thrombocytosis.…”

Section: Discussionmentioning

confidence: 99%

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Extreme reactive thrombocytosis in a healthy 6 year-old child

Caro-Patón

García-Salido

Iglesias-Bouzas

et al. 2014

Anales de Pediatría (English Edition)

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Thrombocytosis is usually found by chance in children. Reactive or secondary thrombocytosis is the more common form, with infectious diseases being the most prevalent cause of it. Regarding the number of platelets there are four degrees of thrombocytosis; in its extreme degree the number of platelets exceeds 1,000,000/mm 3 . We describe a case of extreme reactive thrombocytosis in a healthy 6-year-old child. He required critical care admission for diagnosis and treatment (maximum number of platelets 7,283,000/mm 3 ). We review the different causes of thrombocytosis in childhood, the differential diagnosis, and the available treatments in case of extreme thrombocytosis.Extreme reactive thrombocytosis in a healthy 6 year-old child 319 de plaquetas de 7.283.000/mm 3 ). Se revisan las diferentes causas de trombocitosis en la infancia, se describe el diagnóstico diferencial y se discute sobre los diferentes tratamientos disponibles ante un caso como el descrito.

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Section: Discussionmentioning

confidence: 99%

“…6 The aim must be to treat the underlying infection and rule out a primary cause of thrombocytosis. 3,4,7 Apart from antimicrobial drugs, the treatment will essentially consist of supportive measures. The appearance of vasomotor phenomena must be monitored to initiate aspirin treatment.…”

Section: Discussionmentioning

confidence: 99%

Extreme reactive thrombocytosis in a healthy 6 year-old child

Caro-Patón

García-Salido

Iglesias-Bouzas

et al. 2014

Anales de Pediatría (English Edition)

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“…Thrombocytosis can be seen in many infectious diseases in children, especially in closed area infections such as bones, joints and pleura. In previous studies, it has been shown that reactive larger platelets are generated by cytokines such as IL3-IL6 released secondary to inflammation (29,30). We thought that there might be reactive thrombocytosis due to infection in our patients.…”

Section: Discussionmentioning

confidence: 65%

Ventriculoperitoneal Shunt Infections in Children: Demographical, Clinical Findings and Evaluation of Thrombocyte Parameters

Gündeşli̇oğlu¹,

Haytaoğlu²,

Özsoy³

et al. 2018

J Pediatr Inf

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Objective: We investigated demographic, clinical and laboratory characteristics of children with ventriculoperitoneal (VP) shunt infection in this study. The aim of this study was to make a comparison between the values obtained before and after treatment, and those obtained before treatment and of the control groups in terms of platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) values in the diagnosis of VP shunt infection. Material and Methods: In this study, medical records of patients diagnosed with VP shunt infection between the years 2015-2018 were retrospectively reviewed. Healthy children of similar age groups were selected as the control group. The platelet count, MPV and PDW values of the patients were compared before and after treatment, and before treatment and with the control group. Results:13 (39.4%) female and 20 (60.6%) male patients who were diagnosed with VP shunt infection were included in this study. The median age of the patients was 8 months (min-max: 1-106 month). The most common complaints were nausea and vomiting (66.7%) followed by loss of appetite (57.6%) and fever (51.5%). Growth in the cerebrospinal fluid (CSF) culture of 23 (69.7%) patients was detected and the most common cause was Staphylococcus epidermidis (57.6%). At admission, patients with VP shunt infection had mean follow-up platelet counts of 521.969 ± 143.697 µL (min-max: 256.000-854.000 µL) and 25 patients (75.7%) had thrombocytosis. There was statistically significant Özet Giriş: Bu çalışmada ventriküloperitoneal (VP) şant enfeksiyonu gelişen çocuk hastaların demografik, klinik, laboratuvar özellikleri incelenmiştir. VP şant enfeksiyonu tanısında trombosit sayısı, ortalama trombosit hacmi (OTH), trombosit dağılım aralığı (TDA) değerlerinin tedavi öncesi, tedavi sonrası ve tedavi öncesi ile kontrol grubunun karşılaştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada 2015-2018 yılları arasında VP şant enfeksiyonu tanısı alan hastaların dosyaları geriye dönük olarak incelendi. Benzer yaş grubundan sağlıklı çocuklar kontrol grubu olarak seçildi. Hastaların tedavi öncesi, sonrası ve tedavi öncesi ile kontrol grubu trombosit sayısı, OTH ve TDA değerleri karşılaştırıldı. Bulgular: Bu çalışmaya VP şant enfeksiyonu tanısı alan 13 (%39.4)'ü kız, 20 (%60.6)'si erkek 33 hasta dahil edildi. Hastaların median yaşı 8 ay (minmaks: 1-106 ay) idi. En sık başvuru yakınması bulantı-kusma (%66.7) olup bunu iştahsızlık (%57.6) ve ateş (51.5) izlemekte idi. Hastaların 23 (%69.7)'ünde beyin omurilik sıvısı (BOS) kültüründe üreme tespit edildi ve en sık etken Staphylococcus epidermidis (%57.6) idi. Ventriküloperitoneal şant enfeksiyonu olan hastaların yatışta bakılan ortalama trombosit değerleri 521.969 ± 143.697 µL (min-maks: 256.000-854.000 µL) olup 25 (%75.7)'inde trombositoz mevcut idi. Hastaların tedavi öncesi ve sonrası trombosit sayıları arasında anlamlı fark bulundu (p= 0.001). Tedavi öncesi ve sonrası OTH değerleri karşılaştırıldığında tedavi öncesi ortalama J Pediatr Inf 2018; 12(2): e63-e69 Ventricu...

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“…De forma independiente a la causa de trombocitosis, 7 . De forma independiente a la causa de trombocitosis, 7 .…”

Section: Discussionunclassified

“…El objetivo debe ser tratar la infección subyacente y descartar una causa primaria de trombocitosis 3,4,7 . El tratamiento, salvo los antimicrobianos, será fundamentalmente de soporte.…”

Section: Discussionunclassified

Trombocitosis extrema reactiva en un niño sano de 6 años

Caro-Patón

García-Salido

Iglesias-Bouzas

et al. 2014

Anales de Pediatría

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Thrombocytosis is usually a casual finding in children. Reactive or secondary thrombocytosis is the more common form, being the infections diseases the most prevalent cause of it. Regarding the number of platelets there are four degrees of thrombocytosis; in its extreme degree the number of platelets exceeds 1,000,000/mm(3). We describe a case of extreme reactive thrombocytosis in a healthy 6-year-old child. He required critical care admission for diagnosis and treatment (maximum number of platelets 7,283,000/mm(3)). We review the different causes of thrombocytosis in childhood, the differential diagnosis, and the available treatments in case of extreme thrombocytosis.

show abstract

Associations of Reactive Thrombocytosis With Clinical Characteristics in Pediatric Diseases

Cited by 21 publications

References 19 publications

Extreme reactive thrombocytosis in a healthy 6 year-old child

Extreme reactive thrombocytosis in a healthy 6 year-old child

Ventriculoperitoneal Shunt Infections in Children: Demographical, Clinical Findings and Evaluation of Thrombocyte Parameters

Trombocitosis extrema reactiva en un niño sano de 6 años

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