2018
DOI: 10.1159/000490208
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Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder’s Lung Patients

Abstract: Background/Aims Pigeon breeder’s lung (PBL) results from Th1/Th2 cell imbalance. B cells inhibit the immune activity of Th1, and EBF3 is a key B cell factor. This study explored the relationship between EBF3 and Th1/Th2 imbalance in chronic PBL cases complicated with pulmonary fibrosis (PF). Methods Twenty Uygur PBL+PF patients, 20 pigeon breeders without PBL or PF, and 20 healthy individuals without pigeon breeding history constituted the patient I, negative control, and normal control groups, respectively. P… Show more

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Cited by 13 publications
(18 citation statements)
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“…As a mucolytic agent, NAC not only has the effect of directly dissolving mucus expectorant but also has the effect of anti-in ammatory, antioxidant, increasing the secretion and activity of active substances in the lung (12)(13)(14)(15). A large number of free radicals are produced in ARDS patients.…”
Section: Discussionmentioning
confidence: 99%
“…As a mucolytic agent, NAC not only has the effect of directly dissolving mucus expectorant but also has the effect of anti-in ammatory, antioxidant, increasing the secretion and activity of active substances in the lung (12)(13)(14)(15). A large number of free radicals are produced in ARDS patients.…”
Section: Discussionmentioning
confidence: 99%
“…Our ndings are consistent with Wu's study of INF-g dominance (Th1 cytokine) in pigeon breeder's lung patients at the acute/ sub-acute stage and IL-4 dominance (Th2 cytokine) at the chronic stage aer pulmonary brosis occurred. 48 Recent studies have found that DCs can regulate polarization of Th1/Th2 cells in a variety of diseases, but this regulation in silicosis is rarely reported.…”
Section: 36mentioning
confidence: 99%
“…The existing relationships between the new candidate genes mentioned in this section and other human cancers except for the lung cancer, were also mentioned in the sixth column of Table . The main source we used for this part was DisGeNET database .…”
Section: Resultsmentioning
confidence: 99%
“…The existing relationships between the new candidate genes mentioned in this section and other human cancers except for the lung cancer, were also mentioned in the sixth column of Table 1. 32,51,[57][58][59][60][61][62][63][64] The main source we used for this part was DisGeNET database. 68 Comparison of some associated diseases with the new candidate genes can help in selecting them to be checked experimentally to prove their association with the NSCLC.…”
Section: Candidate New Genes In Association With Nsclcmentioning
confidence: 99%