Associations of prenatal exposure to multiple metals with testicular volume and anogenital distance in infant boys: A longitudinal cohort study

Huang, Lulu; Huang, Sifang; Luo, Xiaoyu; Li, Longman; Chen, Xiang; Zan, Gaohui; Tan, Yanli; Liu, Chaoqun; Hou, Qingzhi; Ge, Xiaoting; Chen, Chunfei; Hong, Xia; Tian, Yuan; Yang, Aimin; Chen, Pan; Li, Mujun; Mo, Zengnan; Yang, Xiaobo

doi:10.1016/j.envint.2020.105900

Cited by 7 publications

(4 citation statements)

References 50 publications

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Section: Methodsmentioning

confidence: 99%

“…The LASSO penalized regression analysis is essentially a coefficient compression method that shrinks the coefficients of nonsignificantly influential variables to zero which could realize both predictor selection and parameter estimation at the same time. 77 , 78 The greater the λ , the more the penalty for the linear model with more variables, and eventually a model with fewer variables is achieved. In the context of that, we conducted LASSO penalized regression analysis with all metals entered in the model to select the crucial metals for AoAC by 10‐fold cross‐validation with penalty term lambda.…”

Section: Methodsmentioning

confidence: 99%

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Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Mo,

Yin,

Wang

et al. 2024

MedComm

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Vascular calcification is a strong predictor of cardiovascular events. Essential metals play critical roles in maintaining human health. However, the association of essential metal levels with risk of aortic arch calcification (AoAC) remains unclear. We measured the plasma concentrations of nine essential metals in a cross‐sectional population and evaluated their individual and combined effects on AoAC risk using multiple statistical methods. We also explored the mediating role of fasting glucose. In the logistic regression model, higher quartiles of magnesium and copper were associated with the decreased AoAC risk, while higher quartile of manganese was associated with higher AoAC risk. The least absolute shrinkage and selection operator penalized regression analysis identified magnesium, manganese, calcium, cobalt, and copper as key metals associated with AoAC risk. The weighted quantile sum regression suggested a combined effect of metal mixture. A linear and positive dose–response relationship was found between manganese and AoAC in males. Moreover, blood glucose might mediate a proportion of 9.38% of the association between manganese exposure and AoAC risk. In summary, five essential metal levels were associated with AoAC and showed combined effect. Fasting glucose might play a significant role in mediating manganese exposure‐associated AoAC risk.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Mo,

Yin,

Wang

et al. 2024

MedComm

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“…Prenatal exposure to metals has been linked to neurodevelopmental outcomes, with specific metals showing negative associations with motor development [ 106 , 107 , 108 ]. While there is evidence that prenatal exposure to aluminium is associated with lower fine motor developmental quotient (DQ) and that cadmium exposure is linked to lower gross motor DQ [ 109 ], it is important to note that the causal mechanisms underlying these associations are not yet fully understood.…”

Section: Advances In Epigenetics Of Dcd and Its Comorbiditymentioning

confidence: 99%

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

et al. 2023

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Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology.

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“…Our data were derived from the Guangxi Birth Cohort Study (GBCS), constructed from July to September in 2015. We recruited pregnant women from 8 Maternity and Child Healthcare Hospitals covering 6 cities of Guangxi (Huang, Huang et al 2020). More detailed information about the cohort can be found in the literatures (Jiang, Hou et al 2018, Wei, Cao et al 2018, Huang, Hou et al 2019).…”

Section: Study Populationmentioning

confidence: 99%

Gender-specific effects of prenatal mixed exposure to multiple serum phthalates on neurodevelopment of children aged 2-3 years ： the Guangxi Birth Cohort Study

Yang

Zheng

et al. 2022

Preprint

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Phthalates have been shown to have adverse effects on neurodevelopment, which may be gender-specific. However, the association between prenatal mixed exposure to phthalates and children's neurodevelopment remain limited. We measured prenatal phthalate levels and children's neurodevelopment. Logistic regression was fitted to examine the association. Among boys, mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP) has adverse effects on gross motor (OR: 7.39, 95% CI:1.42, 38.5). For gross motor in boys, joint effect was discovered between mono-2-ethylhexyl phthalate (MEHP) and MEHHP. Moreover, synergistic effects were found for MEHP with vanadium and cadmium, and antagonistic effects for MEHP with magnesium, calcium, titanium, iron, copper, selenium, rubidium and strontium. We did not find statistically significant relationships in girls. In the 1st trimester, adverse effects were identified between mono-2-ethyl-5-oxoyhexyl phthalate (MEOHP) and adaptation ( P = 0.024), and monomethyl phthalate (MMP) with social area ( P = 0.016). In the 2nd trimester, the risk of social development increased with MEHHP. In summary, we found boys may be more vulnerable to the neurotoxicity than girls in gross motor, and the 1st and 2nd trimester might be more sensitive in terms of phthalates on children. To some extent, supplementation of the appropriate metals in the 1st trimester may reduce or inhibit the absorption of phthalates by the foetus, especially in males, so as to prevent neurodevelopmental impairment.

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Associations of prenatal exposure to multiple metals with testicular volume and anogenital distance in infant boys: A longitudinal cohort study

Cited by 7 publications

References 50 publications

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Associations of essential metals with the risk of aortic arch calcification: a cross‐sectional study in a mid‐aged and older population of Shenzhen, China

Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

Gender-specific effects of prenatal mixed exposure to multiple serum phthalates on neurodevelopment of children aged 2-3 years ： the Guangxi Birth Cohort Study

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