Associations of Prenatal and Postnatal Maternal Depressive Symptoms with Offspring Cognition and Behavior in Mid-Childhood: A Prospective Cohort Study

Faleschini, Sabrina; Rifas‐Shiman, Sheryl L.; Tiemeier, Henning; Oken, Emily; Hivert, Marie‐France

doi:10.3390/ijerph16061007

Cited by 46 publications

(37 citation statements)

References 45 publications

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“…First, ST were reported by parents and thus the data may have been inaccurate, despite this, however, as most of the ST exposure of infants and young children occurs at home, there is good reason to believe that ST was accurately measured. Second, there are many factors that may affect children’s emotional and behavioral problems which were not included in this study as controlled factors, such as maternal emotional problems [ 40 ] and parenting style [ 41 ], we have not controlled these factors. Third, the occurrence of selection bias due to loss-to-follow-up also limits our study.…”

Section: Discussionmentioning

confidence: 99%

Early childhood screen time as a predictor of emotional and behavioral problems in children at 4 years: a birth cohort study in China

Liu

Huang

et al. 2021

Environ Health Prev Med

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Background Previous studies have suggested that screen time (ST) has a negative effect on children’s emotional and behavioral health, but there are few longitudinal studies that have been conducted with infants and toddlers. This study sought to examine the effect of ST in early childhood on emotional and behavioral problems in children aged 4 years, based on a birth cohort study in China. Methods A total of 2492 children aged 4 years were enrolled in this study. The parents and guardians of each child completed a questionnaire that included items eliciting information on children’s birth information, socio-demographic information at baseline, and ST at each follow-up. Emotional and behavioral problems were assessed using the Strengths and Difficulties Questionnaire (SDQ) at 4 years of age. Multivariate logistic analysis was used to explore the effects of ST on emotional and behavioral problems. Results The percentages of children with ST > 0 h/day at age 0.5 years, ST > 2 h/day at age 2.5 years, and ST > 2 h/day at age 4 years were 45.7, 55.5, and 34.5% respectively. The prevalence of emotional and behavioral problems was 10.8%. ST at 6 months was a risk factor for emotional symptoms and hyperactivity at the age of 4 years. ST at age 2.5 years was a risk factor for hyperactivity at the age of 4 years. However, ST at age 4 years was a risk factor for total difficulties, conduct problems, peer problems, hyperactivity, and prosocial behavior. Conclusions Higher ST exposure at early childhood is associated with later emotional and behavioral problems. In particular, sustained high ST exposure is a risk factor for behavioral problems. These findings suggested the importance of controlling ST to prevent the occurrence of emotional and behavioral problems in the early years.

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Section: Discussionmentioning

confidence: 99%

Early childhood screen time as a predictor of emotional and behavioral problems in children at 4 years: a birth cohort study in China

Liu

Huang

et al. 2021

Environ Health Prev Med

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“…16 The impact extends beyond the mother, affecting the mother-child dynamic and continuing to impact the child throughout adolescence with a delay in height, weight, emotional and behavioral development, and academic performance. [17][18][19] Evidence supports a multifactorial pathophysiology of PPD, with contributors ranging from environmental, to genetic, to hormonal, to neurotransmitter dysfunction, as well as interactions between these factors. Although the etiology of PPD is unclear, hormonal changes during pregnancy and postpartum are felt to play an important role for some women.…”

Section: Discussionmentioning

confidence: 99%

Intravenous brexanolone for postpartum depression: what it is, how well does it work, and will it be used?

Faden

Citrome

2020

Therapeutic Advances in Psychopharmacology

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Postpartum depression is considered to be a subtype of major depressive disorder that occurs in approximately 10–20% of mothers worldwide. However, in actuality, these numbers are likely underreported due to minimization and the stigma of mental illness. Until recently, there were no approved medications for the treatment of postpartum depression. Allopregnanolone is a naturally occurring neuroactive steroid whose serum levels decline precipitously following childbirth. This hormonal fluctuation has been postulated as playing a role in the pathophysiology of postpartum depression. Brexanolone is the first medication approved by the US Food and Drug Administration for the treatment of postpartum depression. Brexanolone is an intravenous proprietary formulation of allopregnanolone that can be administered to produce stable serum levels comparable with third-trimester concentrations in postpartum mothers. It is hypothesized to modulate neuronal excitability by functioning as an allosteric modulator of γ-aminobutyric acid-A receptors and is administered under monitoring as a 60 h continuous infusion. In this review, we will highlight the results of the clinical trial program, including efficacy and tolerability data. Practical and logistical considerations of brexanolone will be reviewed, as will its potential place in therapy for the treatment of postpartum depression.

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“…The number of fever episodes would have been a better potential confounder than antibiotic use, but we did not have this variable available. We also included probable prenatal depression and antidepressant use during pregnancy (pregnancy exposure models) because headaches and aches and pains are common symptoms of depression and maternal depression is associated with child behaviours . Adding other potentially confounding variables, including maternal pre‐pregnancy body mass index and alcohol consumption during pregnancy, did not materially change the observed results, so we did not include them in our final models.…”

Section: Methodsmentioning

confidence: 99%

Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid‐childhood executive function and behaviour

Rifas‐Shiman

Cárdenas

Hivert

et al. 2019

Paediatric Perinatal Epid

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Background: Over-the-counter analgesics during pregnancy or infancy may be related to neurobehavioural problems in children, but little is known about effects of different analgesic types, dosage, and timing.Objectives: Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children. Methods:We included 1225 mother-child pairs from Project Viva, a pre-birth cohort study. We assessed prenatal acetaminophen and ibuprofen use in early and mid-pregnancy and infant use in the first year of life using questionnaires. Parents and classroom teachers assessed child behaviours in mid-childhood (median 8 years), using the Behavior Rating Inventory of Executive Function (BRIEF) and the Strengths and Difficulties Questionnaire (SDQ), with higher scores indicating worse functioning for both. We examined associations of acetaminophen and ibuprofen use during pregnancy and infancy with mid-childhood neurobehavioural outcomes using linear regression models adjusted for potential confounders.Results: During pregnancy, 46.1% of mothers used acetaminophen ≥10 times and 18.4% used any ibuprofen. In the first year, 65.3% and 39.6% of infants received acetaminophen and ibuprofen ≥6 times, respectively. Higher (≥10 vs <10 times) prenatal acetaminophen (β 1.64 points; 95% confidence interval [CI] 0.59, 2.68) and any ibuprofen (β 1.56, 95% CI 0.19, 2.92) were associated with higher parent-rated BRIEF global scores. Patterns of association were linear across categories and were similar for other parent-and teacherrated outcomes. Infancy exposure (≥6 vs <6 times) to acetaminophen (β 1.69, 95% CI 0.51, 2.87) and ibuprofen (β 1.40, 95% CI 0.25, 2.55) were associated with higher parent-rated BRIEF GEC scores but associations with teacher-rated scores were weaker.Conclusions: Prenatal and early-life exposure to acetaminophen and ibuprofen were associated with poorer executive function and behaviour in childhood. These findings highlight the need for further research on the mechanisms through which analgesics may act on fetal and child brain development. K E Y W O R D Sacetaminophen, child behaviour, child executive function, ibuprofen, infancy, pregnancy

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Associations of Prenatal and Postnatal Maternal Depressive Symptoms with Offspring Cognition and Behavior in Mid-Childhood: A Prospective Cohort Study

Cited by 46 publications

References 45 publications

Early childhood screen time as a predictor of emotional and behavioral problems in children at 4 years: a birth cohort study in China

Early childhood screen time as a predictor of emotional and behavioral problems in children at 4 years: a birth cohort study in China

Intravenous brexanolone for postpartum depression: what it is, how well does it work, and will it be used?

Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid‐childhood executive function and behaviour

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