Associations of polymorphisms in the β2-adrenergic receptor gene with essential hypertension in Han Chinese population

Abstract

The β2-adrenergic receptor (β2-AR) gene has been implicated in the pathogenesis of hypertension. However, the results have been conflicting. In this study, we performed a meta-analysis to assess the associations of 46A/G and 79C/G polymorphisms in β2-AR gene with hypertension risk in Han Chinese population. Published literature from PubMed, ISI Web of Science, Embase databases, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Eleven studies (2,058 cases and 1,459 controls) for 46A/G polymorphism and eight studies (2,219 cases and 1,495 controls) for 79C/G polymorphism were identified. The results suggested that 46A/G polymorphism G allele might increase the risk of hypertension (GG vs. AA: OR = 1.47, 95 % CI 1.20-1.82). However, no significant association was observed for 79C/G polymorphism (GG vs. CC: OR = 1.05, 95 % CI 0.61-1.79). The results indicated that 46A/G polymorphism in the β2-AR gene was associated with hypertension susceptibility in Han Chinese population.

Asociación y efectos de interacción en los genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2 sobre la hipertensión en población antioqueña

“…Se han llevado a cabo numerosos estudios genéticos sobre estos sistemas; sin embargo, los resultados han sido incongruentes entre poblaciones, lo que evidencia la heterogeneidad de la hipertensión arterial en su etiología genética en las poblaciones continentales (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58).…”

ADRB3 Gene Trp64Arg Polymorphism and Essential Hypertension: A Meta-Analysis Including 9,555 Subjects

“…Information was extracted from a total of 5,088 EH cases and 4,467 controls (Table 1 ) (Fujisawa et al, 1997 ; Baba et al, 1998 ; Tonolo et al, 1999 ; Ringel et al, 2000 ; Thomas et al, 2000 ; Wang Y. et al, 2001 ; Ding et al, 2002 , 2009 ; Liang et al, 2004 ; Masuo et al, 2005 ; Tan et al, 2005 ; Guo et al, 2006 ; Chen et al, 2008 ; Zhang et al, 2012 ; Wang et al, 2013 ; Liu et al, 2015 ; Supplementary Table 2 ). Twenty-five papers were obtained through the search process, among which 16 papers were included for the present meta-analysis.…”

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

“…Furthermore, recent molecular epidemiology studies revealed that certain genetic variants are associated with susceptibility to hypertension. In particular, polymorphisms of genes, including the leptin receptor, angiotensinogen, cytochrome P450, vascular endothelial growth factor, adrenoceptor, ApoB, bradykinin beta 2 receptor, and apolipoprotein CIII, have been associated with the susceptibility to this disease (Charita et al, 2012;Fowdar et al, 2012;Gu et al, 2012;Hamedian et al, 2012;Li and Liu, 2012;Shin et al, 2012;Tang et al, 2012;Xi et al, 2012b). Similar to variants of other genes in the apolipoprotein family, apoE gene polymorphisms may also contribute to the occurrence of hypertension in various populations.…”