Associations of plasma hepcidin with mortality risk in patients with coronary artery disease

Li, Xinrui; Ding, Ding; Zhang, Yuan; Su, Dongfang; Wang, Min; Chen, Xuechen; Yang, Yan; Hong, Chang-jiang; Hu, Gang; Liu, Wenhua

doi:10.18632/oncotarget.22722

Cited by 10 publications

(6 citation statements)

References 48 publications

(49 reference statements)

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“…Similar results were found in a genetic study, in which 12 iron-related genes were assessed [41]. In a large clinical study of 759 patients with ACS and 526 patients with stable CAD, plasma hepcidin was found positively associated with all-cause and CVD mortality in ACS patients [42]. However, other studies have found no significant associations [43,44].…”

Section: Iron Status and Genetic Disorders Associated With Abnormal Isupporting

confidence: 70%

New insights into the role of iron in inflammation and atherosclerosis

et al. 2019

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Iron is fundamental for life-essential processes. However, it can also cause oxidative damage, which is thought to trigger numerous pathologies, including cardiovascular diseases. The role of iron in the pathogenesis of atherosclerosis is still not completely understood. Macrophages are both key players in the handling of iron throughout the body and in the onset, progression and destabilization of atherosclerotic plaques. Iron itself might impact atherosclerosis through its effects on macrophages. However, while targeting iron metabolism within macrophages may have some beneficial effects on preventing atherosclerotic plaque progression there may also be negative consequences. Thus, the prevailing view of iron being capable of accelerating the progression of coronary disease through lipid peroxidation may not fully take into account the multi-faceted role of iron in pathogenesis of atherosclerosis. In this review, we will summarize the current understanding of iron metabolism in the context of the complex interplay between iron, inflammation, and atherosclerosis.

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Section: Iron Status and Genetic Disorders Associated With Abnormal Isupporting

confidence: 70%

New insights into the role of iron in inflammation and atherosclerosis

et al. 2019

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“…Concerning comorbidities at baseline there was an overrepresentation of cardiovascular disease and chronic kidney disease in the sepsis group which might influence the results. Previous studies have found that hepcidin levels are elevated in patients with acute coronary syndrome, in patients with type 2 diabetes mellitus, as well as in chronic kidney disease, CKD 58 – 60 . With the low numbers of patients with CKD in our cohort, 17 patients totally, 12 septic and 5 non-septic patients, statistics are not feasible, but median level of hepcidin was 41.5 nmol/L among the septic patients with CKD whereas only 4.7 nmol/L in the non-septic patients, the latter inconsistent with what has been reported on CKD without sepsis 59 .…”

Section: Discussionmentioning

confidence: 98%

Hepcidin discriminates sepsis from other critical illness at admission to intensive care

Olinder

Börjesson

Norrman

et al. 2022

Sci Rep

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Initial differential diagnosis and prognosis for patients admitted to intensive care with suspected sepsis remain arduous. Hepcidin has emerged as a potential biomarker for sepsis. Here we report data on the relevance of levels of hepcidin versus other biomarkers as a diagnostic and prognostic tool for sepsis. 164 adult patients admitted to the intensive care unit (ICU) within 24 h upon arrival to the hospital were included. Blood samples collected daily for seven consecutive days and hepcidin levels, heparin binding protein (HBP) levels and standard biomarkers were determined. Blood cultures were initiated at inclusion. Clinical scores were evaluated daily and mortality after 28- and 180-days was recorded. One hundred of the patients were found to fulfil the criteria for sepsis whereas 64 did not. Hepcidin levels at admission were significantly higher in the septic than in the non-septic patients. In septic patients hepcidin levels declined significantly already at 24 h followed by a steady decline. A significant negative correlation was observed between hepcidin levels and SAPS 3 in patients with sepsis. Hepcidin levels at inclusion were significantly higher among septic patients that survived 180-days and predicted mortality. Our data show that hepcidin levels are indicative of sepsis in patients admitted to the ICU and has a prognostic value for mortality.

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“…Hepcidin inhibits cholesterol e ux in macrophages and promotes the progression of facilitate plaque, possibly by iron trapping in macrophages [23] , inducing iron-mediated oxidative stress and increasing foam cell formation [24] . With the death of the iron-laden macrophages, the content of atheromatous plaque increased cytotoxicity to surrounding cellular elements and new monocytes are recruited to the vulnerable atherosclerotic plaque [25] . In animal studies, suppression of hepcidin pharmacologically leaded to reduce intracellular iron content in macrophages and increase macrophage cholesterol e ux, thereby decreased the formation of foam cells and atherosclerosis [26] .…”

Section: Discussionmentioning

confidence: 99%

Association of hepcidin with serum lipids, triglyceride-glucose index, and High-sensitivity cardiac troponin T in Metabolic syndrome population

Wang,

Xiao,

Sheng

et al. 2023

Preprint

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Background Hepcidin has been viewed as a reliable surrogate of cardiovascular disease (CVD) risk. We investigate the correlation between Hepcidin with serum lipids, triglyceride-glucose index, and High-sensitivity cardiac troponin T (Hs-cTnT) in community-based population by using Hs-cTnT as measuring indicator for myocardial injury. Methods We analyzed the association of baseline Hepcidin with serum lipids, triglyceride-glucose index, and Hs-cTnT levels in 1447 subjects from a community-based population in Beijing, China. Results There were significant differences in age, sex, smoking, SBP, HDL-C, LDL-C, Sd-LDL, PCSK9, LDL-TG, Apo EH, Lp(a), eGFR, hepcidin and Hs-cTnT between populations with or without Mets (P < 0.05). In correlation analysis, hepcidin was correlated with TG (β = 0.663; p = 0.002), sd-LDL (β = 9.893; p = 0.015), PCSK9 (β = 16.385; p < 0.001), RLP-C (β = 8.530; p = 0.011), LDL-TG (β = 4.652; p = 0.006), and TyG (r = 0.246; p < 0.001). Multiple linear regression analysis showed that baseline hepcidin (β = 0.584, 95%CI:0.236–0.932, P = 0.001) was positively correlated with follow-up Hs-cTnT levels in subjects with Mets. Additionally, HDL-C levels were negatively correlated with follow-up Hs-cTnT levels (β=−0.429, 95% CI: -0.791- -0.066, P = 0.021). In subjects with Mets, Logistics regression model showed that hepcidin was associated with elevated Hs-cTnT (HR = 2.534, 95%CI: 1.267–5.357, P < 0.05), but not for non-Mets group. Model 1 showed that high hepcidin was a risk factor for elevated Hs-cTnT independent of hepcidin, TG, Sd-LDL, PCSK-9, RLP-C, LDL-TG, Lp(a) and HDL-C in subjects with Mets (HR = 3.284; 95%CI: 1.015–10.634, P < 0.001). Conclusions Our findings in a Chinese cohort suggest that hepcidin is a risk factor for elevated Hs-cTnT in patients with Mets.

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Associations of plasma hepcidin with mortality risk in patients with coronary artery disease

Cited by 10 publications

References 48 publications

New insights into the role of iron in inflammation and atherosclerosis

New insights into the role of iron in inflammation and atherosclerosis

Hepcidin discriminates sepsis from other critical illness at admission to intensive care

Association of hepcidin with serum lipids, triglyceride-glucose index, and High-sensitivity cardiac troponin T in Metabolic syndrome population

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