Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease

Wang, Bin; Pan, Jinshun; Wang, Liansheng; Zhu, Haobo; Yu, Rongbin; Zou, Ying

doi:10.1016/j.atherosclerosis.2005.05.008

Cited by 92 publications

(71 citation statements)

References 23 publications

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“…[3][4][5][6][7] The present study was performed to evaluate the possible relationship between oxidative stress and membrane fluidity of RBCs in hypertensive and normotensive men by using the ESR method. The results showed that the order parameter (S) of RBC membranes in the ESR spectra was significantly higher in hypertensive men than in normotensive men, indicating that the membrane fluidity of RBCs was decreased in hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Recent studies have shown that plasma 8-Iso-prostaglandin F2α (8-Iso-PG F2α ) may be a reliable index of oxidative stress in humans. [4][5][6][7] It was demonstrated that the plasma concentration of 8-Iso-PG F2α was significantly increased in subjects with essential hypertension compared with normotensive subjects. 4,5) It has also been shown that plasma 8-Iso-PG F2α levels were elevated in patients with coronary artery disease, particularly in those with hypertension.…”

mentioning

confidence: 99%

“…4,5) It has also been shown that plasma 8-Iso-PG F2α levels were elevated in patients with coronary artery disease, particularly in those with hypertension. 6,7) However, cellular mechanisms of oxidative stress in the pathophysiology of hypertension are not fully understood.…”

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confidence: 99%

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Oxidative Stress and Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men An Electron Spin Resonance Investigation

Tsuda

2010

Int. Heart J.

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SummaryRecent evidence indicates that oxidative stress might actively participate in the pathophysiology of hypertension, atherosclerosis, and other cardiovascular diseases. The purpose of the present study was to assess the possible link between oxidative stress and membrane fluidity in hypertensive and normotensive men. We measured the membrane fluidity (a reciprocal value of membrane microviscosity) of red blood cells (RBCs) in hypertensive and normotensive men using an electron spin resonance (ESR) and spin-labeling method. Membrane fluidity of RBCs was decreased in hypertensive men compared with normotensive men. The levels of plasma 8-Iso-prostaglandin F2α (8-Iso-PG F2α : an index of oxidative stress) were significantly higher in hypertensive men than in normotensive men. In contrast, plasma nitric oxide (NO)-metabolite levels were significantly lower in hypertensive men than in normotensive men. In the overall analysis of hypertensive and normotensive men, plasma 8-Iso-PG F2α levels were inversely correlated with plasma NO-metabolites. Furthermore, the reduced membrane fluidity of RBCs was associated with increased plasma 8-Iso-PG F2α and decreased plasma NO-metabolite levels. In a multivariate regression analysis, plasma 8-Iso-PG F2α was found to be an independent determinant of membrane fluidity of RBCs participate in the pathophysiology of hypertension and atherosclerosis, and might be associated with increased risk of cardiovascular diseases, vascular dysfunction, and the metabolic syndrome.1-3) Recent studies have shown that plasma 8-Iso-prostaglandin F2α (8-Iso-PG F2α ) may be a reliable index of oxidative stress in humans. [4][5][6][7] It was demonstrated that the plasma concentration of 8-Iso-PG F2α was significantly increased in subjects with essential hypertension compared with normotensive subjects. 4,5) It has also been shown that plasma 8-Iso-PG F2α levels were elevated in patients with coronary artery disease, particularly in those with hypertension. 6,7) However, cellular mechanisms of oxidative stress in the pathophysiology of hypertension are not fully understood.Abnormalities in the physical properties of the cell membranes may underlie the defects that are strongly linked to hypertension, stroke, and other cardiovascular disease conditions. 8,9) An electron spin resonance (ESR) and spinlabeling method has been developed to evaluate the membrane fluidity (a reciprocal value of membrane microviscosity) and the perturbations of membrane function by external agents. 8,9) Using the ESR method, we have been performing a series of experiments regarding the membrane fluidity in subjects with essential hypertension. [9][10][11][12][13] The results suggest that the membrane fluidity of red blood cells (RBCs) was significantly lower in hypertensive subjects than in normotensive subjects, indicating that the cell membranes were stiffer and less fluid in essential hypertension. [9][10][11][12][13] Because the deformability of RBCs may be highly dependent on the membrane fluidity, 8) the reduction in...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Oxidative Stress and Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men An Electron Spin Resonance Investigation

Tsuda

2010

Int. Heart J.

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“…[26][27][28] For example, it has been reported that circulating levels of 8-isoprostane were an independent risk factor associated with coronary artery disease in a Chinese population (odds ratio 2.47, P < 0.001), 26) and were associated with peripheral artery disease. 27,28) In this study, we have shown that valsartan therapy decreased urine 8-isoprostane levels up to 12 months in type 2 diabetic subjects with hypertension, despite the fact that the blood pressure levels were unchanged.…”

Section: Discussionmentioning

confidence: 99%

Effects of 12-Month Valsartan Therapy on Glycation and Oxidative Stress Markers in Type 2 Diabetic Subjects With Hypertension

et al. 2008

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SUMMARYAlthough it has been reported that angiotensin II receptor blockers inhibited the formation and accumulation of advanced glycation endproducts (AGEs) in vitro and in vivo, whether they can do so clinically is not clear. We investigated the effects of 12-month valsartan therapy on various markers of inflammation, glycation, and oxidation in type 2 diabetic subjects with hypertension.We started 40 mg/day valsartan treatment in 15 type 2 diabetic patients with hypertension. In 6 patients, the dose of valsartan was increased to 80 mg/day after 6 months and maintained until 12 months. Metabolic parameters including BMI and serum high molecular weight (HMW)-adiponectin, high-sensitivity C-reactive protein (hs-CRP) as an inflammation marker, AGEs, paraoxonase activity, platelet-activating factor (PAF)-acetylhydrolase activity, and urine 8-isoprostane levels were measured at baseline and after 6 and 12 months of treatment. Urine microalbumin level and carotid artery intimamedia thickness (IMT) were also measured.Even after valsartan therapy, the blood pressure levels of the patients were not decreased significantly. Serum AGEs and urine 8-isoprostane levels decreased at both 6 and 12 months (P < 0.05 for both), although other metabolic and oxidative markers were unchanged. Though urine microalbumin levels tended to be decreased after 6 and 12 months of valsartan treatment, the changes were not significant. Mean IMT at 12 months was not changed from the baseline value. In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects. (Int Heart J 2008; 49: 681-689)

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“…Oxidative stress leads to the oxidation of products in vivo and numerous oxidation products have been investigated and their significance examined in atherosclerotic disease [4][5][6][7] . 7-Ketocholesterol is known to be a major component of the cholesterol oxidation product, oxysterols, and is found in high concentrations in atherosclerotic plaques, which contribute to the development of atherosclerosis [8][9][10][11][12][13][14][15][16][17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Serum 7-Ketocholesterol Concentrations in the Progression of Coronary Atherosclerosis

Hatori

Takahashi

Iizuka

et al. 2009

J Atheroscler Thromb

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Aim: 7-Ketocholesterol concentrations can be measured in a blood sample; however, the relationship between blood 7-ketocholesterol concentrations and atherosclerotic disease is not well-known. The aim of this study was to clarify the clinical significance of serum 7-ketocholesterol concentrations (s-7KCHO) in the progression of coronary atherosclerosis. Methods: One hundred and thirty-nine subjects with coronary artery disease (CAD, subjects with stable angina pectoris or acute myocardial infarction) and 43 subjects with normal coronary arteries were enrolled in the study. s-7KCHO was measured using gas chromatography mass spectrometry. Results: s-7KCHO was significantly higher in subjects with CAD than in those with normal coronary arteries (normal coronary artery: 19.0 11.3 ng/mL, CAD: 32.4 23.1 ng/mL, p 0.01). Furthermore, patients with multiple vessel disease had significantly higher s-7KCHO than those with single vessel disease. Multivariate analysis revealed that s-7KCHO was an independent variable for CAD (p 0.01). In CAD subjects, the presence of acute myocardial infarction, number of affected vessels, and high sensitive C-reactive protein concentrations strongly correlated with s-7KCHO (p 0.01, 0.05, 0.05, respectively). Conclusion: These results indicate that high s-7KCHO is closely associated with the progression of coronary atherosclerosis and inflammation.

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Associations of plasma 8-isoprostane levels with the presence and extent of coronary stenosis in patients with coronary artery disease

Cited by 92 publications

References 23 publications

Oxidative Stress and Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men An Electron Spin Resonance Investigation

Oxidative Stress and Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men An Electron Spin Resonance Investigation

Effects of 12-Month Valsartan Therapy on Glycation and Oxidative Stress Markers in Type 2 Diabetic Subjects With Hypertension

Clinical Significance of Serum 7-Ketocholesterol Concentrations in the Progression of Coronary Atherosclerosis

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