Associations of physical activity intensities, impact intensities and osteogenic index with proximal femur bone traits among sedentary older adults

Savikangas, Tiina; Sipilä, Sarianna; Rantalainen, Timo

doi:10.1016/j.bone.2020.115704

Cited by 5 publications

(2 citation statements)

References 41 publications

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“…However, when low MVPA levels were present, increasing LPA while proportionally reducing MVPA, SB, and sleep has been significantly associated with higher total body aBMD using compositional data analysis (38). Moreover, LPA has been shown to decelerate age-related bone loss in older adults (47). These positive findings of LPA align with our results in peri/postpubertal survivors who also had low MVPA levels (21.2 min·d −1 ).…”

Section: Discussionmentioning

confidence: 99%

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

MARMOL-PEREZ,

MIGUELES,

UBAGO-GUISADO

et al. 2024

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose We aimed to examine the associations of 24-hour movement behaviors (moderate-to-vigorous physical activity [MVPA], light physical activity [LPA], sedentary behavior [SB] and sleep) with age-, sex- and race-specific areal bone mineral density (aBMD) Z-score parameters at clinical sites in young pediatric cancer survivors. Methods This cross-sectional multicenter study was carried out within the iBoneFIT framework in which 116 young pediatric cancer survivors (12.1 ± 3.3 years old; 42% female) were recruited. We obtained anthropometric and body composition data (i.e., body mass, stature, body mass index and region-specific lean mass), time spent in movement behaviors over at least seven consecutive 24-hour periods (wGT3x-BT accelerometer, ActiGraph) and aBMD Z-score parameters (age-, sex- and race-specific total at the body, total hip, femoral neck and lumbar spine). Survivors were classified according to somatic maturity (pre or peri/post-pubertal depending on the estimated years from peak height velocity). The adjusted models’ coefficients were used to predict the effect of reallocating time proportionally across behaviors on the outcomes. Results In pre-pubertal young pediatric cancer survivors, reallocating time to MVPA from LPA, SB and sleep was significantly associated with higher aBMD at total body (B = 1.765, P = .005), total hip (B = 1.709, P = .003) and lumbar spine (B = 2.093, P = .001). In peri/post-pubertal survivors, reallocating time to LPA from MVPA, SB and sleep was significantly associated with higher aBMD at all sites (B = 2.090 to 2.609, P = .003 to .038). Reallocating time to SB from MVPA or LPA was significantly associated with lower aBMD at most sites in pre-pubertal and peri/post-pubertal survivors, respectively. Finally, reallocating time to sleep from MVPA, LPA and SB was significantly associated with lower aBMD at total body (B = -2.572, P = .036) and total hip (B = -3.371, P = .015). Conclusions These findings suggest that every move counts and underline the benefits of increasing MVPA or LPA, when low MVPA levels are present, for bone regeneration following pediatric cancer treatment completion.

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Section: Discussionmentioning

confidence: 99%

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

MARMOL-PEREZ,

MIGUELES,

UBAGO-GUISADO

et al. 2024

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Whilst we could not calculate these indices in our study our data agree with previous work in older adults. The PASSWORD study used the osteogenic index [ 26 ] and found, as in the current Hertfordshire cohort, that low-impact daily PA may decelerate age-related bone loss and that due to low levels of high-impact activity, this alone could not prevent age-related loss. Together these data that suggest mechanoadaptation of ageing, whereby the set-points of the mechanostat/ sensitivity of osteocytes to changes in strain may adjust to lower levels of loading from muscles.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Activity Profiles in Older Adults and Lower Limb Bone Parameters: Observations from the Hertfordshire Cohort Study

et al. 2022

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As muscle strength and function decline with age the optimal high-impact physical activity (PA) required for bone remodelling is rarely achievable in older adults. This study aimed to explore the activity profiles of community-dwelling older men and women and to assess the relationship between individual PA profiles and lower limb bone parameters. Participants from the Hertfordshire Cohort Study wore triaxial accelerometers for 7 days and counts of low (0.5–1.0 g), medium (1.0–1.5 g), and high (> 1.5 g) vertical-impact activity were calculated. Two years later, participants underwent a pQCT scan of the tibia (4% and 38% sites) to obtain measures of bone mineral density and bone geometry. Linear regression was used to quantify associations between bone and PA loading profiles adjusting for age, sex, loading category, and BMI. Results are presented as β [95% confidence interval]. Bone and PA data were available for 82 participants. The mean (SD) age at follow-up was 81.4(2.7) years, 41.5% (n = 34) were women. The median low-impact PA count was 5281 (Inter-quartile range (IQR) 2516–12,977), compared with a median of only 189 (IQR 54–593) in medium, and 39 (IQR 9–105) in high-impact counts. Positive associations between high-impact PA and cortical area (mm2), polar SSI (mm3), and total area (mm2) at the 38% slice (6.21 [0.88, 11.54]; 61.94 [25.73, 98.14]; 10.09 [3.18, 16.99], respectively). No significant associations were found at distal tibia. These data suggest that maintaining high (> 1.5 g)-impact activity is difficult for older adults to achieve; however, even small amounts of high-impact PA are positively associated with selected cortical bone parameters 2 years later.

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Changes in femoral neck bone mineral density and structural strength during a 12-month multicomponent exercise intervention among older adults – Does accelerometer-measured physical activity matter?

Savikangas,

Suominen,

Alén

et al. 2024

Bone

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Associations of physical activity intensities, impact intensities and osteogenic index with proximal femur bone traits among sedentary older adults

Cited by 5 publications

References 41 publications

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

Assessment of Activity Profiles in Older Adults and Lower Limb Bone Parameters: Observations from the Hertfordshire Cohort Study

Changes in femoral neck bone mineral density and structural strength during a 12-month multicomponent exercise intervention among older adults – Does accelerometer-measured physical activity matter?

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