Associations of Peritoneal Glucose Load With Male Sexual Dysfunction and Depression in Peritoneal Dialysis Patients

Abstract

This cross-sectional study examined possible associations of peritoneal glucose load with male sexual dysfunction and depression in peritoneal dialysis patients. Compared to patients with peritoneal glucose load ≤3 g/kg per day, those with load >3 g/kg per day had higher Beck Depression Inventory scores, (18.9 ± 5.4 vs. 11.4 ± 5.8, P = 0.002) and lower International Index of Erectile Function scores, serum total testosterone and DHEA [(15.4 ± 6.4 vs. 45.1 ± 20.7, P < 0.001), (8.5 ± 3.0 vs. 13.9 ± 3.2, P < 0.001), (113.9 ± 58.8 vs. 280.2 ± 128.3, P < 0.001); respectively)]. Of participants with peritoneal glucose load >3 g/kg per day, 84.6% had mild to moderate erectile dysfunction and 92.3% had abnormal Beck Depression Inventory scores. Peritoneal glucose load inversely correlated with International Index of Erectile Function scores (P < 0.001), total serum testosterone (P = 0.002) and serum DHEA (P = 0.001); and directly with Beck Depression Inventory scores (P < 0.001) and serum estradiol (P < 0.001). This study demonstrated higher prevalence of sexual dysfunction, depression and sex hormone disturbances in male peritoneal dialysis patients receiving higher peritoneal glucose load.

Multifaceted Sexual Dysfunction in Dialyzing Men and Women: Pathophysiology, Diagnostics, and Therapeutics

“…The most common sexual disturbance in the dialyzing man is erectile dysfunction, with a prevalence ranging between 51.9% [ 76 ], 77% [ 118 ], 80.6% [ 119 ], 83% [ 120 ], and 88% [ 78 ]. ED is, in itself, multifactorial, resulting from vascular, neurological, and/or psychological derangements in addition to the CKD-related hormone abnormalities [ 121 ].…”

“…In a comparative study by Hassan et al [ 121 ], high peritoneal glucose load index (PGLI) in male patients receiving maintenance PD was correlated with higher prevalence of ED and depression. Patients with PGLI > 3 g/day reported significantly poorer sexual function and lower serum total testosterone.…”

Can passive pedaling improve sexual function in patients under hemodialysis? A randomized clinical trial

“…There are a variety of sexual and reproductive disorders in men and women with kidney failure, including erectile dysfunction in men, decreased libido, anovulation, and infertility in women. The causes of these disorders can be organic or psychogenic [5,8,9].…”