Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Jeddi, Maryam Zare; Zuanna, Teresa Dalla; Barbieri, Giulia; Fabricio, Aline S C; Daprà, Francesca; Fletcher, Tony; Russo, Federico; Pitter, Gisella; Canova, Cristina

doi:10.3390/ijerph18031194

Cited by 23 publications

(23 citation statements)

References 45 publications

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“…The relationship between PFAS and HDL-c is also unclear. In a previous study from the US [ 29 ], PFOA was associated with HDL-c positively, as with the current results, while negatively based on another study from Italy [ 30 ].…”

Section: Discussionsupporting

confidence: 89%

“…In 3629 American adults aged ≥20 years, there were inverse associations between triglycerides and PFNA and PFDA (respectively, 1.00 and 0.25) [ 31 ]. In a previous study from Italy, including 15,876 young adults aged 20–39 years, PFNA (0.53–0.58) was negatively associated with BMI [ 30 ]. Although the mechanisms by which PFAS may decrease the odds of certain biomarkers are unknown, the inverse association observed in this study may contemplate the anti-inflammatory and/or reduced insulin resistance effects of certain PFAS, as well as their potentially high oxygen-carrying capacity [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Neto

Polcrová

Pospíšilová

et al. 2022

IJERPH

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Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25–89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant (p < 0.05) associations between the ln-transformed PFOA and glucose (β = 0.01), systolic (β = 0.76) and diastolic blood pressure (β = 0.65); total cholesterol (β = 0.07) and LDL-c (β = 0.04); and PFOS with glucose (β = 0.03), BMI (β = 2.26), waist circumference (β = 7.89), systolic blood pressure (β = 1.18), total cholesterol (β = 0.13), and HDL-c (β = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Neto

Polcrová

Pospíšilová

et al. 2022

IJERPH

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“…The results did not support the hypothesis of an association between PFAS and metabolic syndrome. However, a statistically significant positive association between PFAS plasma concentration and individual components of the metabolic syndrome, namely increased blood pressure and elevated plasma triglycerides, was observed (44).…”

Section: Pfas-related Metabolic and Hypertensive Disordersmentioning

confidence: 90%

“…A large population-based cross-sectional observational study performed in the Veneto region found an association between some PFAS (in particular PFOA, PFOS, and PFHxS) and total, HDL and LDL cholesterol, as well as between PFOA,PFHxS and triglycerides (43,44).…”

Section: Pfas-related Metabolic and Hypertensive Disordersmentioning

confidence: 99%

Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence

et al. 2021

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Polyfluoro- and perfluoro–alkyl substances (PFAS) are organic chemicals extensively used worldwide for industry and consumer products. Due to their chemical stability, PFAS represent a major cause of environmental pollution. PFAS accumulate in animal and human blood and tissues exerting their toxicity. We performed a review of the epidemiological studies exploring the relationship between exposure to PFAS and thromboembolic cardiovascular disease. An increase in cardiovascular disease or death related to PFAS exposure has been reported from cross-sectional and longitudinal observational studies with evidence concerning the relation with early vascular lesions and atherosclerosis. Several studies indicate an alteration in lipid and glucose metabolism disorders and increased blood pressure as a possible link with cardiovascular thromboembolic events. We also examined the recent evidence indicating that legacy and new PFAS can be incorporated in platelet cell membranes giving a solid rationale to the observed increase risk of cardiovascular events in the populations exposed to PFAS by directly promoting thrombus formation. Exposure to PFAS has been related to altered plasma membrane fluidity and associated with altered calcium signal and increased platelet response to agonists, both in vitro and ex vivo in subjects exposed to PFAS. All the functional responses are increased in platelets by incorporation of PFAS: adhesion, aggregation, microvesicles release and experimental thrombus formation. These findings offer mechanistic support the hypothesis that platelet-centred mechanisms may be implicated in the increase in cardiovascular events observed in populations chronically exposed to PFAS.

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“…[47][48][49] Three studies have reported negative associations between PFAS body burden and body size characteristics. 47,50,51 Moreover, several studies have reported no associations between PFAS body burden and body size. [52][53][54][55][56] To date, epidemiological studies do not support consistent associations between PFAS and obesity.…”

Section: Obesitymentioning

confidence: 99%

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

Schlezinger,

Gokce

2024

Circulation Research

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Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and cardiovascular risk have garnered the most headlines and are strong, but less attention has been paid to other omnipresent toxicants in our ecosystem. Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are man-made chemicals that are extensively used in industrial and consumer products worldwide and in aqueous film-forming foam utilized in firefighting. As such, our exposure to PFAS is essentially ubiquitous. Given the long half-lives of these degradation-resistant chemicals, virtually, all people are carrying a body burden of PFAS. Health concerns related to PFAS are growing such that the National Academies of Sciences, Engineering and Medicine has recommended standards for clinical follow-up of individuals with high PFAS blood levels, including prioritizing screening for dyslipidemia. The link between PFAS and dyslipidemia has been extensively investigated, and evidence for associations is compelling. However, dyslipidemia is not the only cardiovascular risk factor with which PFAS is associated. Here, we review the epidemiological evidence for links between PFAS of concern identified by the National Academies of Sciences, Engineering and Medicine and risk factors for cardiovascular disease, including overweight/obesity, glucose intolerance, hypertension, dyslipidemia, and hyperuricemia. Moreover, we review the potential connections of PFAS with vascular disease and atherosclerosis. While observational data support associations between the National Academies of Sciences, Engineering and Medicine PFAS and selected cardiac risk factors, additional research is needed to establish causation and better understand how exposure to PFAS leads to the development of these conditions.

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Associations of Perfluoroalkyl Substances with Prevalence of Metabolic Syndrome in Highly Exposed Young Adult Community Residents—A Cross-Sectional Study in Veneto Region, Italy

Cited by 23 publications

References 45 publications

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study

Exposure to Perfluoroalkyl Chemicals and Cardiovascular Disease: Experimental and Epidemiological Evidence

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk

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