Associations of Objectively and Subjectively Measured Sleep Quality with Subsequent Cognitive Decline in Older Community-Dwelling Men: The MrOS Sleep Study

Blackwell, Terri; Yaffe, Kristine; Laffan, Alison M.; Ancoli‐Israel, Sonia; Redline, Susan; Ensrud, Kristine E.; Song, Yeonsu; Stone, Katie L.

doi:10.5665/sleep.3562

Cited by 182 publications

(123 citation statements)

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“…These symptoms are of particular concern in older subjects, because they may be misinterpreted as symptoms of dementia/mild cognitive impairment (MCI) (Roth and Ancoli‐Israel, 1999). There is a strong association of objectively and subjectively measured sleep quality with subsequent cognitive decline (Osorio et al, 2011; Blackwell et al, 2014). …”

Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

557

350

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In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light–dark cycle to invigorate and optimize the internal temporal order. The SCN‐activated, light‐inhibited production of melatonin conveys the message of darkness to the clock and induces night‐state physiological functions, for example, sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo‐controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm‐related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non‐restorative) sleep quality, non‐dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD). The diminished production of melatonin at the very early stages of AD, the role of melatonin in the restorative value of sleep (perceived sleep quality) and its sleep‐anticipating effects resulting in attenuated activation of certain brain networks are gaining a new perspective as the role of poor sleep quality in the build‐up of β amyloid, particularly in the precuneus, is unravelled. As a result of the recently discovered relationship between circadian clock, sleep and neurodegeneration, new prospects of using melatonin for early intervention, to promote healthy physical and mental ageing, are of prime interest in view of the emerging link to the aetiology of Alzheimer's disease.Linked ArticlesThis article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc

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Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

557

350

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“…Among the 27 studies identified for the meta-analysis, there were 8 cross-sectional, 31,37,44-49 1 case-control, 50 2 retrospective cohort, 33,51 and 16 prospective cohort 32,34,36,[38][39][40][52][53][54][55][56][57][58][59][60][61] (Table 1). Of these, 15 were considered to be of high quality, 10 were of medium quality, and 2 were of low quality.…”

Section: Design and Qualitymentioning

confidence: 99%

Sleep, Cognitive impairment, and Alzheimer’s disease: A Systematic Review and Meta-Analysis

Bubu

Brannick

Mortimer

et al. 2016

Sleep

444

299

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Institution at which work was performed: University of South FloridaStudy Objectives: Mounting evidence implicates disturbed sleep or lack of sleep as one of the risk factors for Alzheimer's disease (AD), but the extent of the risk is uncertain. We conducted a broad systematic review and meta-analysis to quantify the effect of sleep problems/disorders on cognitive impairment and AD. Methods: Original published literature assessing any association of sleep problems or disorders with cognitive impairment or AD was identified by searching PubMed, Embase, Web of Science, and the Cochrane library. Effect estimates of individual studies were pooled and relative risks (RR) and 95% confidence intervals (CI) were calculated using random effects models. We also estimated the population attributable risk. Results: Twenty-seven observational studies (n = 69 216 participants) that provided 52 RR estimates were included in the meta-analysis. Individuals with sleep problems had a 1.55 (95% CI: 1.25-1.93), 1.65 (95% CI: 1.45-1.86), and 3.78 (95% CI: 2.27-6.30) times higher risk of AD, cognitive impairment, and preclinical AD than individuals without sleep problems, respectively. The overall meta-analysis revealed that individuals with sleep problems had a 1.68 (95% CI: 1.51-1.87) times higher risk for the combined outcome of cognitive impairment and/or AD. Approximately 15% of AD in the population may be attributed to sleep problems. Conclusion:This meta-analysis confirmed the association between sleep and cognitive impairment or AD and, for the first time, consolidated the evidence to provide an "average" magnitude of effect. As sleep problems are of a growing concern in the population, these findings are of interest for potential prevention of AD.

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“…Table 1 shows the general characteristics of the included studies. Seven studies [10,11,35,37,38,40,41] involved cognitive impairment, 2 studies involved dementia [36,39] , and 1 study involved both cognitive impairment and dementia [42] . The included studies were published between 2009 and 2015, spanning 6 years.…”

Section: Characteristics Of Studies Included In the Final Analysismentioning

confidence: 99%

Longer Duration of Sleep and Risk of Cognitive Decline: A Meta-Analysis of Observational Studies

Kim

Myung²,

Lee³

et al. 2016

Neuroepidemiology

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Background: Previous observational epidemiological studies have reported inconsistent findings about the association between longer durations of sleep and the risk of cognitive impairment and dementia. To investigate the association between longer durations of sleep and the risk of cognitive decline, we performed a meta-analysis of observational studies. Methods: We searched PubMed, EMBASE, and the bibliographies of relevant articles to retrieve additional studies in July 2015. A total of 53,942 participants (mean age 66.9 years) were included in the final analysis. Three evaluators independently reviewed and selected articles, based on pre-determined selection criteria. Results: Among a total of 695 articles, 10 observational epidemiological studies with 3 case-control studies and 7 cohort studies were included in the final analysis. Compared to the average sleep duration, the odds ratio or relative risk of the longest sleep duration was 1.42 (95% CI 1.27-1.59) for cognitive decline in the fixed-effect meta-analysis, 1.38 for cognitive impairment (95% CI 1.23-1.56), and 1.42 for dementia (95% CI 1.15-1.77). Subgroup meta-analyses by various factors such as study design, type of cognitive decline, gender, region, age, and methodological quality of study showed consistent findings. Conclusion: The current meta-analysis found that longer duration of sleep is associated with an increased risk of cognitive decline.

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Associations of Objectively and Subjectively Measured Sleep Quality with Subsequent Cognitive Decline in Older Community-Dwelling Men: The MrOS Sleep Study

Abstract: Among older community-dwelling men, reduced sleep efficiency, greater nighttime wakefulness, greater number of long wake episodes, and poor self-reported sleep quality were associated with subsequent cognitive decline.

Cited by 182 publications

References 47 publications

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Sleep, Cognitive impairment, and Alzheimer’s disease: A Systematic Review and Meta-Analysis

Longer Duration of Sleep and Risk of Cognitive Decline: A Meta-Analysis of Observational Studies

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