Associations of Obesity With Growth and Puberty in Children: A Cross-Sectional Study in Fuzhou, China

Zhang, Ying; Yuan, Xin; Yang, Xiuwen; Lin, Xiaoqin; Cai, Chunyan; Chen, Shijun; Ai, Zhuanzhuan; Shangguan, Huakun; Wu, Wenyong; Chen, Ruimin

doi:10.3389/ijph.2023.1605433

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…Previous epidemiological studies and genetic evidence have consistently indicated a causal association between obesity in girls and earlier puberty onset [ 7 , 8 , 10 , 42 , 43 , 44 ]. Our study confirmed that childhood obesity and increased BMI contributed to a younger age of menarche and increased Tanner stage in girls, offering further support for these conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies have linked obesity to the onset of puberty [ 7 ], although this association remains controversial. Most of the evidence from case–control, cross-sectional, and longitudinal studies has shown that childhood obesity, higher body fat percentage, and body mass index (BMI) are strongly associated with increased Tanner stage, early menarche age, and risk of precocious puberty in girls [ 8 , 9 , 10 ]. However, the rate of pubertal development was found to be decelerated in girls with obesity [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study

Jin,

Zhao

2024

Metabolites

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Epidemiological studies have linked obesity to the onset of puberty, while its causality and the potential metabolite mediators remain unclear. We employed a two-sample Mendelian randomization (MR) design to evaluate the causal effects of obesity on puberty onset and its associated diseases including type 2 diabetes (T2D) and cardiovascular diseases (CVDs). The potential mediators in this pathway were further explored using a two-step MR design. The robustness of our findings was evaluated using sensitivity analyses. Our MR results revealed that childhood obesity/BMI were causally associated with an increased Tanner stage in girls, younger age at menarche, and increased risk of adulthood T2D and CVD. However, neither childhood BMI nor obesity had a causal effect on the Tanner stage in boys. Mediation analysis further indicated that increased creatine served as a mediator for the causal pathway from childhood obesity/BMI to the Tanner stage of girls, while early puberty onset in girls played a mediating role in the pathway linking childhood obesity to increased risk of adulthood T2D and CVD. This study indicated that the risk of early puberty onset in girls and its associated health issues can be potentially reduced by preventing childhood obesity. The involvement of creatine in this process needs to be further validated and explored.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study

Jin,

Zhao

2024

Metabolites

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“…Metabolomics analysis may reveal important biological pathways in the pathophysiology of children with overweight and obesity and reconcile the existing conflicting evidence in children. Ying Zhang et al found that obesity had an obvious influence on growth in both genders; the obesity group was significantly taller than the nonobesity group after 4 years of age [12]. Therefore, in this study, 473 children were divided…”

Section: Introductionmentioning

confidence: 89%

Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics

Wu,

Li,

Zhu

et al. 2023

Obesity

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ObjectiveThe aim of this study was to identify the differential metabolic characteristics of children with overweight and obesity and understand their potential mechanism in different age stratifications.MethodsFour hundred seventy‐three children were recruited and divided into two age stratifications: >4 years (older children) and ≤4 years (younger children), and overweight and obesity were defined according to their BMI percentile. A one dimensional proton nuclear magnetic resonance (1H‐NMR)–based metabolomics strategy combined with pattern recognition methods was used to identify the metabolic characteristics of childhood overweight and obesity.ResultsFour and sixteen potential biomarkers related to overweight and two and twenty potential biomarkers related to obesity were identified from younger and older children, respectively. Fluctuations in phenylalanine, tyrosine, glutamine, leucine, histidine, and ascorbate co‐occurred in children with obesity at two age stratifications. The disturbances in biosynthesis and metabolism of amino acids, lipid metabolism, and galactose metabolism disturbance were mainly involved in children with overweight and obesity.ConclusionsThe metabolic disturbances show a significant progression from overweight to obesity in children, and different metabolic characteristics were demonstrated in age stratifications. The changes in the levels of phenylalanine, tyrosine, glutamine, leucine, histidine, and ascorbate were tracked with the persistence of childhood obesity. These findings will promote the mechanistic understanding of childhood overweight and obesity.

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“…This is consistent with the previous studies. Ying Zhang et al showed that obesity children were taller with advanced BA in early childhood, and earlier onset of puberty [39]. Akridge et al showed that the BAD of obese children aged 9-12.9 years was 1.60 years, while that of obese children aged 13-15.5 years was 0.69 years [40].…”

Section: Risk Of Advanced or Delayed Ba Developmentmentioning

confidence: 99%

Correlation of Bone Age Development with Overweight and Obesity in 23305 Children from Beijing

Zhou,

Qu,

et al. 2024

Preprint

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Purpose The aim was to observe the influence of different nutritional status on bone age change according to BMI and analyze the risk of advanced bone age in overweight and obese children. Methods Total 23305 children from Beijing in this cross-section study were analyzed. Childhood overweight and obesity are defined according to the China and WHO growth criteria. Data are analyzed by STATA software and the R language version 4.3.0. Results Under China criteria, 29%, 15% and 4% of overweight boys, 33%, 33% and 3% of obese boys, while 39%, 25% and 2% of overweight girls, 37%, 42% and 1% of obese girls had advanced, significantly advanced and delayed BA. After adjustment, overweight (odds ratio, 95% confidence interval, P under China criteria: 2.52, 2.30 to 2.75, < 0.001 and 4.54, 4.06 to 5.09, < 0.001) and obesity (4.31, 3.85 to 4.82, < 0.001 and 14.01, 12.39 to 15.85, < 0.001) were risk factors of both advanced BA and significantly advanced BA. Conclusions Different nutritional status leads to different children's BA development, overweight and obese children have a higher rate of advanced BA under two growth criteria, and girls are more obvious than boys. Overweight and obesity were risk factors of advanced BA.

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Associations of Obesity With Growth and Puberty in Children: A Cross-Sectional Study in Fuzhou, China

Cited by 5 publications

References 48 publications

Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study

Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study

Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics

Correlation of Bone Age Development with Overweight and Obesity in 23305 Children from Beijing

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