Associations of novel inflammatory markers with long‐term outcomes and recurrence of diverticulitis

Zager, Yaniv; Horesh, Nir; Assaf, Dan; Aharoni, Mor; Khalilieh, Saed; Cordoba, Mario; Gutman, Mordechai; Rosin, Danny

doi:10.1111/ans.16220

Cited by 12 publications

(16 citation statements)

References 17 publications

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“…In most patients with recurrent episodes of acute diverticulitis, biomarkers were elevated both in the first episode and in recurrent attacks. This suggests that NLR might be related to an inflammatory load [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil-to-lymphocyte ratio as a predictor of complicated acute diverticulitis: A retrospective cohort study

Huatuco

Pachajoa

Bruera

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction Currently, the debate on the usefulness of Neutrophil to Lymphocyte Ratio (NLR) as a predictor of complications in acute diverticulitis (AD) remains open, especially, the relation to the severity of the disease, the clinical impact, and the necessity of minimally invasive or emergency surgical procedures. On the other hand, its diagnostic efficacy has not been studied even in our field. The objective of the present study was to determine the utility and diagnostic precision of NLR in complicated acute diverticulitis (cAD). Methods Descriptive, retrospective cohort and analytical study. Patients older than 18 years with a diagnosis of AD were included, from 2013 to 2018. Demographic variables, days of hospitalization, leukocyte count, neutrophils, lymphocytes, ESR, CRP, and NLR were analyzed. The sensitivity and specificity for the diagnosis of cAD were determined using ROC curves. Results 325 patients were included. Of these 196 (60%) were men. The median age was 52 years. A total of 30 (9%) were categorized as cAD. The patients with cAD presented mean values in the leukocyte count (14.02 ± 4.49 × 10 9 /l; p < 0.01), CRP (119.60 ± 87.67; p < 0.01) and NLR (7.61 ± 4.03; p < 0.01). An NLR cutoff value ≥ 4.2 was identified as the most appropriate to distinguish cAD, with a sensitivity of 80%, a specificity of 64%, NPV of 96%, and PPV of 18%. Conclusion NLR is a predictive marker of cAD, with a cut-off point of 4.2 being the best diagnostic approach.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, its diagnostic efficacy has not been studied even in our field. Up until now, there are only four studies published in Ireland [ 11 ], Israel [ 12 , 13 ], and South Korea [ 14 ]. The purpose of the study was to determine the usefulness and diagnostic accuracy of NLR in complicated acute diverticulitis (cAD).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio as a predictor of complicated acute diverticulitis: A retrospective cohort study

Huatuco

Pachajoa

Bruera

et al. 2021

Annals of Medicine &Amp; Surgery

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“…Mari et al reported higher mean PLR values in patients who were operated compared to those treated with nonoperative treatment for only complicated diverticulitis [32]. Zager et al suggested that PLR may be related to an in ammatory burden, which may explain the value of PLR in predicting the interval of time between episodes of diverticulitis [33]. Our study demonstrated that PLR was a risk factor for non-operative treatment failure regardless of complicated or uncomplicated diverticulitis.…”

Section: Discussionmentioning

confidence: 47%

Platelet to lymphocyte ratio is a risk factor for failure of non-operative treatment of colonic diverticulitis

Kim

Han

Lee

et al. 2022

Preprint

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Introduction: Non-operative treatment is the mainstay of colonic diverticulitis, but some patients require surgery due to non-operative treatment failure. This study aims to identify risk factors for the failure of non-operative treatment of colonic diverticulitis. Methods: From January 2011 to December 2020, we retrospectively reviewed 2362 patients with non-operative treatment for first-attack acute diverticulitis. Patients were categorized into non-operative treatment success or failure groups. Clinical characteristics and serum inflammatory markers were analyzed by multivariable logistic regression to determine risk factors for non-operative treatment failure of colonic diverticulitis. Results: Overall, 2.2% (n = 50) of patients underwent delayed surgery within 30 days (median 4.0 [ 3.0; 8.0]) due to non-operative treatment failure. Multivariable logistic regression identified that platelet to lymphocyte ratio (odds ratio [OR], 4.2; 95% confidence interval [CI], 0.05–0.13; p < 0.001), diabetes mellitus (OR, 2.2; 95% CI, 0.01–0.09; p = 0.025), left-sided colonic diverticulitis (OR, 4.1; 95% CI, 0.04–0.13; p < 0.001), and modified Hinchey classification (OR, 6.2; 95% CI, 0.09–0.17; p< 0.001) were risk factors for non-operative treatment failure. Conclusions: Platelet to lymphocyte ratio (PLR) is a potential risk factor for the non-operative treatment failure of acute first-attack colonic diverticulitis. Therefore, patients with higher PLR during non-operative treatment should be monitored with special caution.

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“…Mari et al reported higher mean PLR values in patients who were operated compared to those treated with non-operative treatment for only complicated diverticulitis 32 . Zager et al suggested that PLR may be related to an in ammatory burden, which may explain the value of PLR in predicting the interval of time between episodes of diverticulitis 33 .…”

Section: Discussionmentioning

confidence: 99%

Platelet to lymphocyte ratio is a risk factor for failure of non-operative treatment of colonic diverticulitis

Kim

Han

Lee

et al. 2023

Preprint

View full text Add to dashboard Cite

Non-operative treatment is the mainstay of colonic diverticulitis, but some patients require surgery due to non-operative treatment failure. This study aims to identify risk factors for the failure of non-operative treatment of colonic diverticulitis. From January 2011 to December 2020, we retrospectively reviewed 2362 patients with non-operative treatment for first-attack acute diverticulitis. Patients were categorized into non-operative treatment success or failure groups. Clinical characteristics and serum inflammatory markers were analyzed by multivariable logistic regression to determine risk factors for non-operative treatment failure of colonic diverticulitis. Overall, 2.2% (n = 50) of patients underwent delayed surgery within 30 days (median 4.0 [3.0; 8.0]) due to non-operative treatment failure. Multivariable logistic regression identified that platelet to lymphocyte ratio (odds ratio [OR], 4.2; 95% confidence interval [CI], 0.05–0.13; p < 0.001), diabetes mellitus (OR, 2.2; 95% CI, 0.01–0.09; p = 0.025), left-sided colonic diverticulitis (OR, 4.1; 95% CI, 0.04–0.13; p < 0.001), and modified Hinchey classification (OR, 6.2; 95% CI, 0.09–0.17; p < 0.001) were risk factors for non-operative treatment failure. Platelet to lymphocyte ratio (PLR) is a potential risk factor for the non-operative treatment failure of acute first-attack colonic diverticulitis. Therefore, patients with higher PLR during non-operative treatment should be monitored with special caution.

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Associations of novel inflammatory markers with long‐term outcomes and recurrence of diverticulitis

Cited by 12 publications

References 17 publications

Neutrophil-to-lymphocyte ratio as a predictor of complicated acute diverticulitis: A retrospective cohort study

Neutrophil-to-lymphocyte ratio as a predictor of complicated acute diverticulitis: A retrospective cohort study

Platelet to lymphocyte ratio is a risk factor for failure of non-operative treatment of colonic diverticulitis

Platelet to lymphocyte ratio is a risk factor for failure of non-operative treatment of colonic diverticulitis

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