Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan

Dou, Horng-Yunn; Tseng, Fan-Chen; Lu, Jang‐Jih; Jou, Ruwen; Tsai, Shih‐Feng; Chang, Jinghua Tsai; Lin, Chih-Wei; Miu, Wei-Chieh; Su, Ih‐Jen

doi:10.1016/j.meegid.2008.02.003

Cited by 30 publications

(38 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparative studies of the Mycobacterium tuberculosis population structure have generated interest in understanding its epidemiological relevance to human disease (2,3,9,15,21). One of the most extensively studied clades with respect to host-pathogen compatibility is the Beijing family (5,7,8,16,23), which is highly prevalent in East Asia (26).…”

mentioning

confidence: 99%

Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan

Iwamoto¹,

Fujiyama²,

Yoshida

et al. 2009

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan

Iwamoto¹,

Fujiyama²,

Yoshida

et al. 2009

J Clin Microbiol

View full text Add to dashboard Cite

show abstract

“…Tuberculosis remains a major public health issue in Taiwan and throughout the world 11, 12, 20 . Over the past years, the development of genotyping methods for molecular epidemiological study of TB has advanced our understanding of the transmission of MTB in human populations.…”

Section: Discussionmentioning

confidence: 99%

“…We previously demonstrated that the Beijing ancient strain and the Haarlem strain are the predominant MTB strains infecting aborigines in eastern Taiwan (Hualien City), whereas the East-African Indian (EAI) strain is prevalent in southern Taiwan aborigines, and the Beijing modern strain is predominant in Han Chinese 11–14 . Taiwan is a relatively isolated island, serving as a mixing vessel for colonization by different waves of ethnic and migratory groups over the past 4 centuries.…”

Section: Introductionmentioning

confidence: 99%

“…By using molecular methods, we previously identified close associations of the major MTB lineages in Taiwan (Beijing, EAI, Haarlem, and Latin-American Mediterranean (LAM) strains) to historical migrations of different ethnic populations to the island 14 . In the present study, six MTB strains – isolates of the Beijing ancient sublineage, the Beijing modern sublineage, Haarlem, EAI, T1, and LAM – representing the major types of clinical strains isolated from three different ethnic groups (aboriginals, Han Chinese, ‘veterans’) in Taiwan 11, 12 were subjected to whole-genome sequencing using next-generation sequencing technology (Roche 454/Illumina GAIIx) 15–17 . Based on comparative genome analysis, we identified 60 and 141 strain-specific single nucleotide polymorphisms (SNPs) in the PE/PPE and non-PE/PPE gene families, respectively, when we compared these six genomes to that of the H37Rv reference strain.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lineage-specific SNPs for genotyping of Mycobacterium tuberculosis clinical isolates

Dou

Lin

Chen

et al. 2017

Sci Rep

Self Cite

View full text Add to dashboard Cite

Tuberculosis (TB) is a severe infectious disease worldwide. Genetic variation of the causative agent, Mycobacterium tuberculosis (MTB), determines the outcomes of infection and anti-TB treatment. Until recently, there has been no effective and convenient way for classifying clinical isolates based on the DNA sequences of the divergent lineages of MTB infecting human populations. Here, we identified single nucleotide polymorphisms (SNPs) of six representative strains from Taiwan by whole-genome sequencing and comparing the results to the sequence of the H37Rv reference strain. One hundred and ten SNPs, each unique to one of the six strains, were used to genotype 150 additional isolates by applying DNA mass spectrometry. Lineage-specific SNPs were identified that could distinguish the major lineages of the clinical isolates. A subset including 32 SNPs was found to be sufficient to type four major groups of MTB isolates in Taiwan (ancient Beijing, modern Beijing, East African–Indian, and Latin-American Mediterranean). However, there was high genetic homozygosity within the Euro-American lineage, which included spoligotype-classified Haarlem and T strains. By whole-genome sequencing of 12 representative Euro-American isolates, we identified multiple subtype-specific SNPs which allowed us to distinguish two major branches within the Euro-American lineage.

show abstract

“…Epidemiological surveillance indicated that the Beijing lineage was the most prevalent strain in Taiwan, followed by EAI and Haarlem strains (1, 2). The percentages of isolated LAM strains were around 1% to 7% (2, 3). …”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of the Mycobacterium tuberculosis Clinical Isolate C2, Belonging to the Latin American–Mediterranean Family

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan

Cited by 30 publications

References 28 publications

Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan

Population Structure Dynamics of Mycobacterium tuberculosis Beijing Strains during Past Decades in Japan

Lineage-specific SNPs for genotyping of Mycobacterium tuberculosis clinical isolates

Draft Genome Sequence of the Mycobacterium tuberculosis Clinical Isolate C2, Belonging to the Latin American–Mediterranean Family

Contact Info

Product

Resources

About