Associations of muscle depletion with health status. Another gender difference in COPD?

Verhage, T.L.; Heijdra, Yvonne F.; Molema, Johan; Vercoulen, Jan H.; Dekhuijzen, Richard

doi:10.1016/j.clnu.2010.09.013

Cited by 23 publications

(15 citation statements)

References 23 publications

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“…Loss of muscle mass is greater in patients with moderate-to-severe COPD [88] and muscle mass depletion impacts quality of life. This concept is under discussion and some authors suggest a link between muscle mass loss, decreased carbon monoxide diffusion capacity and static hyperinflation [89]. This would tie in with the more common emphysematous phenotype in women.…”

Section: Nonsmoking-related Copdmentioning

confidence: 99%

Women and COPD: do we need more evidence?

et al. 2019

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@ERSpublicationsThe face of COPD is increasingly female. We need more evidence and a change in how the disease is managed.ABSTRACT The increasingly female face of chronic obstructive pulmonary disease (COPD) prevalence among women has equalled that of men since 2008, due in part to increased tobacco use among women worldwide and exposure to biomass fuels. This finding is supported by a number of characteristics. There is evidence of susceptibility to smoking and other airborne contaminants, along with epidemiological and phenotypic manifestations. COPD has thus become the leading cause of death in women in the USA. The clinical presentation is characterised by increasingly pronounced dyspnoea with a marked tendency towards anxiety and depression, undernutrition, nonsmall cell lung cancer (especially adenocarcinoma) and osteoporosis. Quality of life is also more significantly impacted. The theories advanced to explain these differences involve the role played by oestrogens, impaired gas exchange in the lungs and smoking habits. While these differences require appropriate therapeutic responses (smoking cessation, pulmonary rehabilitation, long-term oxygen therapy), barriers to the treatment of women with COPD include greater under-diagnosis than in men, fewer spirometry tests and medical consultations. Faced with this serious public health problem, we need to update and adapt our knowledge to the epidemiological changes.

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Section: Nonsmoking-related Copdmentioning

confidence: 99%

Women and COPD: do we need more evidence?

et al. 2019

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“…A loss of skeletal muscle mass (sarcopenia) is very frequently observed in chronic diseases such as obstructive pulmonary disease, malignant tumors, chronic rheumatoid arthritis, and cirrhosis, and when sarcopenia accompanies these diseases, the incidence of adverse events increases and the prognosis worsens (1)(2)(3)(4). In addition, in such chronic diseases, a reduced fat mass, or undernutrition, is also known to lead to a poor prognosis (5).…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia and Sarcopenic Obesity Are Prognostic Factors for Overall Survival in Patients with Cirrhosis

et al. 2016

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Objective Although the prognosis is known to be poor in cirrhosis patients associated with sarcopenia, the relationships among skeletal muscle, visceral fat, and the liver have not yet been thoroughly investigated. Therefore, the prognosis and its associations with body composition and the severity of liver disease were examined in patients with cirrhosis. Methods The skeletal muscle mass and visceral fat area were measured in 161 patients with cirrhosis, the effects of body composition on the prognosis were analyzed, and any factors that contribute to changes in body composition were assessed. Results During the mean observation period of 1,005 days, 73 patients died. Patients with sarcopenia or sarcopenic obesity had a poor prognosis, and this difference was pronounced in the subset of patients classified as Child-Pugh class A. A decreased skeletal muscle mass was strongly correlated with decreased serum albumin levels. Sarcopenia is a common feature of advanced cirrhosis, and transitions were observed from normal body composition to sarcopenia and from obese to sarcopenic obesity. Conclusion The body composition is a prognostic factor for cirrhosis, and a better body composition may be advantageous for obtaining a long-term survival in patients with cirrhosis.

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“…21 These differences in strength and muscle mass remain consistent, 22 even in the presence of chronic lung disease where men have been observed to have worse pulmonary function than women. Generally, women have less skeletal muscle and strength than men, and this can impair functional ability especially during older age.…”

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confidence: 71%