Associations of Mortality and Diabetes Complications in Patients With Type 1 and Type 2 Diabetes

Cusick, Michael; Meleth, Annal D.; Agrón, Elvira; Fisher, Marion R.; Reed, George F.; Knatterud, Genell L.; Barton, Franca B.; Davis, Matthew D.; Ferris, Frederick L.; Chew, Emily Y.

doi:10.2337/diacare.28.3.617

Cited by 176 publications

(142 citation statements)

References 66 publications

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“…Furthermore, vision loss due to retinopathy is a serious complication of diabetes and is associated with significant morbidity including increased falls, hip fractures and a fourfold increase in mortality [2,29]. A large American study conducted in the largest county in Los Angeles evaluated the use of teleretinal diabetic retinopathy screening (with optometrists conducting the analysis) and found improved efficiency, quality and access to care [30].…”

Section: Discussionmentioning

confidence: 99%

Nurse-led diabetic retinopathy screening: a pilot study to evaluate a new approach to vision care for Canadian Aboriginal peoples

Spurr

Bullin

Bally

et al. 2018

International Journal of Circumpolar Health

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Diabetic retinopathy is the most common cause of new cases of blindness and is pandemic among Aboriginal people around the world. To reduce health inequities, accessible vision screening among these high-risk populations is essential. To assess cardio-metabolic co-morbidities associated with type 2 diabetes and the use of a portable fundus camera as a novel approach for convenient, earlier and more accessible vision screening for Aboriginal peoples living with type 2 diabetes in northern and remote Canadian communities. This quantitative pilot study screened participants diagnosed with type 2 diabetes for commonly associated cardio-metabolic co-morbidities using anthropometrical measurements, blood pressure and a A1c (HbA1c) blood glucose test, followed by vision exams conducted first by a trained nurse and then by an ophthalmologist to screen for signs of retinopathy using fundus photography. Large numbers of the participants presented with overweight/obese (84.8%), pre-hypertension/hypertension (69.7%) and an elevated A1C (78.8%). Inter-rater reliability demonstrated substantial agreement between vision exam judgements made by the nurse and ophthalmologist (k = .67). Nurse-led vision screening in remote or northern communities can improve the standard of care by extending access to health services, lowering the costs to families by reducing travel expenses and preventing vision loss in a family member.

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Section: Discussionmentioning

confidence: 99%

Nurse-led diabetic retinopathy screening: a pilot study to evaluate a new approach to vision care for Canadian Aboriginal peoples

Spurr

Bullin

Bally

et al. 2018

International Journal of Circumpolar Health

View full text Add to dashboard Cite

show abstract

“…All-cause mortality rate per 1,000 personyears was 15.3 in type 1 diabetic men, 10.3 in type 1 diabetic women, 15.6 in type 2 diabetic men, and 16.1 in type 2 diabetic women in the age-group of 50 -59 years (13). In contrast, the World Health Organization Multinational Study of Vascular Disease in Diabetes Study demonstrated that type 2 diabetic women had lower relative CVD mortality compared with that in type 1 diabetic subjects and type 2 diabetic men (14).…”

Section: -Total and Cvd Mortality During 18 Years Of Follow-up In Typmentioning

confidence: 99%

Similarity of the Impact of Type 1 and Type 2 Diabetes on Cardiovascular Mortality in Middle-Aged Subjects

et al. 2008

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OBJECTIVE -To compare the risk of cardiovascular disease (CVD) death and the impact of hyperglycemia on the risk of CVD mortality associated with type 1 diabetes to that associated with type 2 diabetes.RESEARCH DESIGN AND METHODS -The study comprised 173 participants with type 1 diabetes, 834 participants with type 2 diabetes, and 1,294 nondiabetic participants, aged 45-64 years at baseline and free of CVD. The age of onset of diabetes was Ͼ30 years in both diabetic groups.RESULTS -During an 18-year follow-up, 86 participants with type 1 diabetes, 567 participants with type 2 diabetes, and 252 nondiabetic participants died. CVD mortality rates per 1,000 person-years were 23.1 (95% CI 16.9 -31.9) in type 1 diabetic, 35.3 (30.8 -40.4) in type 2 diabetic, and 4.6 (3.8 -5.7) in nondiabetic participants. Adjusted hazard ratios for CVD mortality in participants with type 1 diabetes versus no diabetes was 3.6 (95% CI 2.2-5.7) in men and 13.3 (6.9 -22.5) in women and in participants with type 2 diabetes versus no diabetes 3.3 (2.5-4.5) in men and 10.1 (6.7-17.4) in women. An increment of 1 unit (%) of GHb increased CVD mortality by 52.5% (95% CI 28.4 -81.3) in type 1 diabetic subjects and by 7.5% (4.3-10.8) in type 2 diabetic participants.CONCLUSIONS -The impact of type 1 and type 2 diabetes on CVD mortality was similar. The effect of increasing hyperglycemia on the risk of CVD mortality was more profound in type 1 than in type 2 diabetic subjects.

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“…Since both entities have previously been shown to be independent predictors of mortality [4,5], the aim of the present study was to measure p75NTR immunoreactivity semi-quantitatively in patients with type 2 diabetes and to investigate correlations with different aspects of diabetic neuropathy.…”

mentioning

confidence: 99%

Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients

et al. 2007

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Aims/hypothesis The p75 neurotrophin receptor (p75NTR) has been shown to appear in the plasma of diabetic rats, possibly indicating diabetic neuropathy. The aim of this study was to use a semi-quantitative assay for human plasma p75NTR to investigate whether this receptor is a marker of peripheral diabetic neuropathy (DPN) and autonomic cardiovascular neuropathy (CAN) in type 2 diabetic patients. Subjects and methods Eighty type 2 diabetic patients and 25 controls without diabetes were analysed for p75NTR immunoreactivity by western blot analysis. DPN was assessed using the Neuropathy Disability Score (NDS). Cardiovascular autonomic function was detected using a standardised analysis of heart rate variability. Results Three distinct p75NTR signals were detectable in human plasma at ∼75, ∼51 and ∼24 kDa, representing the full length receptor (FL) and its intracellular domain (ICD) and extracellular domain (ECD), respectively. Levels of total plasma p75NTR immunoreactivity in patients with type 2 diabetes were similar to those in controls. Type 2 diabetic patients had significantly higher plasma levels of ICD and lower levels of ECD. However, there were no correlations of total p75NTR immunoreactivity or ECD or ICD immunoreactivity with NDS or aspects of CAN. Conclusions/interpretation Levels of the ECD of p75NTR are reduced and levels of the ICD are increased in the plasma of type 2 diabetic patients. None of the p75NTR subunits identified in human plasma seem to be a marker of peripheral or autonomic neuronal function in patients with type 2 diabetes.

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Associations of Mortality and Diabetes Complications in Patients With Type 1 and Type 2 Diabetes

Cited by 176 publications

References 66 publications

Nurse-led diabetic retinopathy screening: a pilot study to evaluate a new approach to vision care for Canadian Aboriginal peoples

Nurse-led diabetic retinopathy screening: a pilot study to evaluate a new approach to vision care for Canadian Aboriginal peoples

Similarity of the Impact of Type 1 and Type 2 Diabetes on Cardiovascular Mortality in Middle-Aged Subjects

Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients

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