Associations of maternal circulating 25‐hydroxyvitamin D3 concentration with pregnancy and birth outcomes

Rodriguez, Angela C. Incollingo; García-Esteban, Raquel; Basterretxea, Mikel; Lertxundi, Aitana; Rodríguez‐Bernal, Clara L.; Íñiguez, Carmen; Rodríguez-Dehli, Cristina; Tardón, Adonina; Espada, Mercedes; Sunyer, Jordi; Morales, Eva

doi:10.1111/1471-0528.13074

Cited by 108 publications

(115 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study we did not found any significant difference between the two groups with respect to the total number of maternal and fetal complications similarly Rodriguez et al 19 did not find any association between maternal circulating 25(OH)D3 concentration in pregnancy with GDM and preterm delivery. In our study the serum vitamin D levels in both the groups had no impact on the neonatal birth weight.…”

Section: Discussion:-supporting

confidence: 66%

A Study on Prevalence of Vitamin D Deficiency in Soft Ware Pregnant Women and the Feto Maternal Outcome.

Sneha¹,

HimaBindu²

2017

IJAR

View full text Add to dashboard Cite

Section: Discussion:-supporting

confidence: 66%

A Study on Prevalence of Vitamin D Deficiency in Soft Ware Pregnant Women and the Feto Maternal Outcome.

Sneha¹,

HimaBindu²

2017

IJAR

View full text Add to dashboard Cite

“…The score for one article, however, was unable to be evaluated because the full text was not available, and three RCT had low risk of bias. Table 1 lists the characteristics of the 18 observational studies 9,[12][13][14][15][16][17][18][19][20][21][22][23][24][30][31][32] and six RCT. [33][34][35][36][37][38] There was some disparity in the definition of PTB between studies.…”

Section: Literature Searchmentioning

confidence: 99%

“…11 Most observational studies, however, did not show a significant relationship. 9,[12][13][14][15][16][17][18][19][20][21][22][23][24] A trial of vitamin D supplementation suggested that 25-OHD serum concentration > 100 nmol/L (vs <50 nmol/L) could significantly reduce the risk of PTB. 25 Other studies, however, did not obtain the same results.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Zhou

Tao

Huang

et al. 2017

J of Obstet and Gynaecol

110

View full text Add to dashboard Cite

Aim: We performed a meta-analysis of randomized controlled trials (RCT) and observational studies to answer the two following questions: (i) whether low maternal circulating 25 hydroxyvitamin D (25-OHD) is associated with an increased risk of preterm birth (PTB) or spontaneous PTB (sPTB); and (ii) whether vitamin D supplementation alone during pregnancy can reduce the risk of PTB. Methods: Literature search was carried out using Pubmed, Web of Science and Embase databases up to June 2016. Pooled OR or relative risk (RR) with 95%CI were computed using fixed or random effects models depending on the size of heterogeneity. Subgroup analysis was used to explore potential sources of between-study heterogeneity. Publication bias was evaluated using Egger's test and Begg's test. Results: Twenty-four articles (six RCT and 18 observational studies) were identified. Maternal circulating 25-OHD deficiency (pooled OR, 1.25; 95%CI: 1.13-1.38) rather than insufficiency (pooled OR, 1.09; 95%CI: 0.89-1.35) was associated with an increased risk of PTB, and vitamin D supplementation alone during pregnancy could reduce the risk of PTB (pooled RR, 0.57; 95%CI: 0.36-0.91). This was also the case for the sPTB subgroup (circulating 25-OHD <50 vs >50 nmol/L; pooled OR, 1.45; 95%CI: 1.20-1.75). Conclusions: Maternal circulating 25-OHD deficiency could increase PTB risk and vitamin D supplementation alone during pregnancy could reduce PTB risk. Extrapolation of the results, however, must be done with caution, and there is urgent need for larger, better-designed RCT to confirm this effect.

show abstract

“…Different fetal growth patterns and body proportions may lead to the same birth weight. Not much is known about the direct effects of maternal vitamin D status on fetal growth and development patterns in healthy populations (8,(10)(11)(12)(13). The inconsistent results from previous studies may be explained by differences between study populations.…”

Section: Introductionmentioning

confidence: 97%

“…Also, vitamin D is important for placental function, calcium homeostasis, and bone mineralization, which are all important determinants for fetal growth and development (5,6). Thus far, to our knowledge, most published studies that have focused on the associations of maternal vitamin D status during pregnancy with fetal development have been based mainly on birth weight and have shown inconsistent results (7)(8)(9). However, birth weight is just a proxy for fetal growth and development.…”

Section: Introductionmentioning

confidence: 99%

Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

Miliku

Vinkhuyzen

Blanken³

et al. 2016

The American Journal of Clinical Nutrition

142

View full text Add to dashboard Cite

. Vitamin D concentrations were analyzed continuously and in quartiles. Fetal head circumference and body length and weight were estimated by repeated ultrasounds, and preterm birth (gestational age ,37 wk) and small size for gestational age (less than the fifth percentile) were determined. Results: Adjusted multivariate regression analyses showed that, compared with mothers with second-trimester 25(OH)D concentrations in the highest quartile, those with 25(OH)D concentrations in the lower quartiles had offspring with third-trimester fetal growth restriction, leading to a smaller head circumference, shorter body length, and lower body weight at birth (all P , 0.05). Mothers who had 25(OH)D concentrations in the lowest quartile had an increased risk of preterm delivery (OR: 1.72; 95% CI: 1.14, 2.60) and children who were small for gestational age (OR: 2.07; 95% CI: 1.33, 3.22). The estimated population attributable risk of 25(OH)D concentrations ,50 nmol/L for preterm birth or small size for gestational age were 17.3% and 22.6%, respectively. The observed associations were not based on extreme 25(OH)D deficiency, but presented within the common ranges. Conclusions: Low maternal 25(OH)D concentrations are associated with proportional fetal growth restriction and with an increased risk of preterm birth and small size for gestational age at birth. Further studies are needed to investigate the causality of these associations and the potential for public health interventions.Am J Clin Nutr 2016;103:1514-22.

show abstract

Associations of maternal circulating 25‐hydroxyvitamin D3 concentration with pregnancy and birth outcomes

Abstract: Main outcome measures Gestational diabetes mellitus (GDM), preterm delivery, caesarean section, fetal growth restriction (FGR) and small-for-gestational age (SGA), anthropometric birth outcomes including weight, length and head circumference (HC).

Cited by 108 publications

References 45 publications

A Study on Prevalence of Vitamin D Deficiency in Soft Ware Pregnant Women and the Feto Maternal Outcome.

A Study on Prevalence of Vitamin D Deficiency in Soft Ware Pregnant Women and the Feto Maternal Outcome.

Vitamin D and risk of preterm birth: Up‐to‐date meta‐analysis of randomized controlled trials and observational studies

Maternal vitamin D concentrations during pregnancy, fetal growth patterns, and risks of adverse birth outcomes

Contact Info

Product

Resources

About