Associations of low handgrip strength with cancer mortality: a multicentre observational study

Abstract

Background Handgrip strength (HGS) is associated with poor clinical outcomes, including all-cause, non-cardiovascular, and cardiovascular mortalities. The published cutoff points for HGS are mostly based on community populations from Western countries, lacking information on cancer patients from China. The objective of this study was to establish sex-specific cutoff points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality. Methods We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancer patients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer-specific mortality was calculated using Cox proportional hazard regression models. Results Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58 years old. The cutoff points of HGS to best classify patients with respect to time to mortality were <16.1 kg for women and <22 kg for men. Low HGS was associated with overall cancer mortality in both women and men [

Association Between Low Handgrip Strength and 90-Day Mortality Among Older Chinese Inpatients: A National Multicenter Prospective Cohort Study

“…In contrast, participants in our study were general inpatients and suffered from various types of disease, not exclusively from cancer. In our study, the prevalence of low handgrip strength was 49.57%, higher than in the study by Zhuang et al ( 13 ) (25.7%). The difference may be due to the fact that the average age in our study was much higher, at 72.39 vs. 58 years old.…”

“…In comparison, this meta-analysis only included one study on older Chinese adults, with only 99 participants. A recent larger study on the Chinese population conducted by Zhuang et al ( 13 ), exploring the correlation between handgrip strength (HGS) and mortality, showed that older adults with low HGS had a strongly increased risk of overall cancer mortality. In contrast, participants in our study were general inpatients and suffered from various types of disease, not exclusively from cancer.…”

“…Also, the Chua et al study ( 12 ) did not perform subgroup or interaction analysis based on gender, age, frailty, or depression. Meanwhile, Zhuang et al ( 13 ), who conducted a large-scale study of 8,267 cancer patients in China, found that low handgrip is strongly associated with an increased risk of cancer mortality. As mentioned above, these two studies explored this association for a Chinese population; however, studies examining the association between low handgrip strength and 90-day mortality in older Chinese hospitalized patients are limited.…”

Tratamento Hormonioterápico Não Altera a Força De Preensão Manual Em Mulheres Sobreviventes Do Câncer De Mama.

“…Partindo desse pressuposto, Zhuang et al, 17 demostraram que pacientes com diferentes tipos de câncer, incluindo o câncer mama eram mais propensos a terem baixa FPM. Corroborando com esses achados, Christensen et al, demostraram que pacientes com câncer tem prejuízos significativos na força muscular, independentemente do estágio da doença, quando comparado a indivíduos saudáveis de mesma faixa etária, gênero, índice de massa corporal e nível de atividade física.…”

Impact of lower extremity muscle strength on the clinical outcome of patients with allogeneic hematopoietic stem cell transplantation

“…Pre-transplant physical function has been reported to be related to post-transplant survival [2,3], and muscle strength is a factor that directly affects these physical functions. Although muscle strength has been reported to be associated with survival in healthy adults [4] and in patients with cancer [5], there are no reports on its association with long-term prognosis in allo-HSCT. As a factor related to muscle strength, skeletal muscle mass measured by computed tomography (CT) imaging has been reported to be associated with long-term prognosis after transplantation [6][7][8].…”