Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study

Song, Mengmeng; Zhang, Qi; Tang, Meng; Zhang, Xi; Ruan, Guo‐Tian; Zhang, Kangping; Ge, Yi‐Zhong; Yang, Ming; Li, Xiangrui; Liu, Xiaoyue; Li, Wei; Ma, Cong; Wang, Kunhua; Song, Chunhua; Shi, Hanping

doi:10.1002/jcsm.12778

Cited by 30 publications

(28 citation statements)

References 42 publications

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“…This phenomenon also suggests that the HGS/W is an effective and vital parameter for RMM assessment, which was consistent with a previous study that indicated that HGS could provide significant prognostic information about complication and mortality risks for medical inpatients at nutritional risk, and help to recognize patients gaining most from medical nutrition treatment [ 32 ]. Moreover, a multicenter observational study proved the association between low HGS and a poor survival probability in one year of patients with cancer cachexia [ 33 ]. According to the latest research, HGS/W exhibited better accuracy in predicting a prognosis than using HGS alone [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Mid-Arm Muscle Circumference or Body Weight-Standardized Hand Grip Strength in the GLIM Superiorly Predicts Survival in Chinese Colorectal Cancer Patients

Xu²,

Zou³

et al. 2022

Nutrients

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Our objective was to identify the optimal method to assess reduced muscle mass (RMM) using the Global Leadership Initiative on Malnutrition (GLIM) approach and investigate the roles of the GLIM approach in nutrition assessment and survival prediction in colorectal cancer (CRC) patients. During a median follow-up period of 4.2 (4.0, 4.4) years, a development cohort of 3612 CRC patients with a mean age of 64.09 ± 12.45 years was observed, as well as an external validation cohort of 875 CRC patients. Kaplan–Meier curves and multivariate Cox regression were adopted to analyze the association between GLIM-diagnosed malnutrition and the overall survival (OS) of CRC patients. A nomogram predicting individualized survival was constructed based on independent prognostic predictors. The concordance index, calibration curve, and decision curve were applied to appraise the discrimination, accuracy, and clinical efficacy of the nomogram, respectively. Patients diagnosed with severe malnutrition based on either the mid-arm muscle circumference (MAMC) or body weight-standardized hand grip strength (HGS/W) method had the highest mortality hazard ratio (HR, 1.51; 95% CI, 1.34–1.70; p < 0.001). GLIM-defined malnutrition was diagnosed in 47.6% of patients. Severe malnutrition was an independent mortality risk factor for OS (HR, 1.25; 95% CI, 1.10–1.42; p < 0.001). The GLIM nomogram showed good performance in predicting the survival of CRC patients and was clinically beneficial. Our findings support the effectiveness of GLIM in diagnosing malnutrition and predicting OS in CRC patients.

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Section: Discussionmentioning

confidence: 99%

Mid-Arm Muscle Circumference or Body Weight-Standardized Hand Grip Strength in the GLIM Superiorly Predicts Survival in Chinese Colorectal Cancer Patients

Xu²,

Zou³

et al. 2022

Nutrients

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“…This was a prospective, cross-sectional, multicenter cohort study-”INSCOC” (Investigation on Nutrition Status and its Clinical Outcome of Common Cancers) ( 27 ), which collected the clinical information from patients with cancer in China between 2013 and 2021. The INSCOC cohort prospectively collected data on nutrition and clinical outcomes in patients with cancer, and the cohort was followed up for 8 years.…”

Section: Methodsmentioning

confidence: 99%

A Novel Inflammation and Insulin Resistance Related Indicator to Predict the Survival of Patients With Cancer

et al. 2022

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BackgroundSystemic inflammation and insulin resistance (IR) are closely related in patients with cancer. However, there is no relevant indicator that combines inflammation and IR to predict patient prognosis. Therefore, this study aimed to develop and validate a novel inflammation- and IR-related marker in patients with cancer.MethodsThe total cohort of this study included 5221 patients with cancer, and the training and validation cohorts were randomized in a 7:3 ratio. C-reactive protein (CRP) and fasting triglyceride glucose (TyG) were used to reflect patients’ inflammation and IR status, respectively. The CRP-TyG index (CTI) was composed of CRP and TyG. The concordance (C)-index, receiver operator characteristic (ROC) curve, and calibration curve reflected the prognostic predictive power of CTI. Univariate and multivariate survival analyses predicted the prognostic value of CTI in patients with cancer.ResultsThe C-indices of CTI in patients with cancer were 0.636, 0.617, and 0.631 in the total, training, and validation cohorts, respectively. The 1-, 3-, and 5-year ROC and calibration curves showed that CTI had a good predictive ability of survival in patients with cancer. Meanwhile, patients with high CTI had a worse prognosis compared to patients with low CTI (total cohort: hazard ratio [HR] = 1.46, 95% confidence interval [95% CI] = 1.33–1.59; training cohort: HR = 1.36, 95% CI = 1.22–1.52; validation cohort: HR = 1.73, 95% CI = 1.47–2.04].ConclusionThe CTI is a useful prognostic indicator of poor prognosis and a promising tool for treatment strategy decision-making in patients with cancer.

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“…Hand grip strength (HGS) is a simple and effective method for measuring muscle strength, which is easy to perform and has low associated costs. Reportedly, HGS can provide important additional prognostic information for malignancies 19,20 . Therefore, this study aimed to develop a simple and practical HGS‐based CXI (H‐CXI) to predict the risk of cancer cachexia and to evaluate its short‐term and long‐term potential prognostic utility in patients with cancer.…”

Section: Introductionmentioning

confidence: 99%

Hand grip strength‐based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer

Xie

Ruan

Wei

et al. 2022

J cachexia sarcopenia muscle

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Background The cachexia index is a useful predictor for cancer cachexia and prognostic assessment. However, its use is limited because of high testing costs and complicated testing procedures. Thus, in this study, we aimed to develop a hand grip strength (HGS)‐based cancer cachexia index (H‐CXI) as a potential predictor of cancer cachexia and prognosis in patients with cancer. Methods Here, 14 682 patients with cancer were studied, including the discovery (6592), internal validation (2820) and external validation (5270) cohorts. The H‐CXI was calculated as [HGS (kg)/height (m)2 × serum albumin (g/L)]/neutrophil‐to‐lymphocyte ratio. The Kaplan–Meier method was used to create survival curves, and the log‐rank test was used to compare time–event relationships between groups. A Cox proportional hazard regression model was used to determine independent risk factors for overall survival (OS). Logistic regression analysis was used to assess the association of the H‐CXI with short‐term outcomes and cancer cachexia. Results There was a significant non‐linear relationship between the H‐CXI and OS in all cohorts. Patients with a low H‐CXI had significantly lower OS than those with a high H‐CXI in the discovery cohort (6‐year survival percentage: 55.72% vs. 76.70%, log‐rank P < 0.001), internal validation cohort (6‐year survival percentage: 55.81% vs. 76.70%, log‐rank P < 0.001), external validation cohort (6‐year survival percentage: 56.05% vs. 75.48%, log‐rank P < 0.001) and total cohort (6‐year survival percentage: 55.86% vs. 76.27%, log‐rank P < 0.001). Notably, the prognostic stratification effect of the H‐CXI in patients with advanced‐stage disease was more significant than that in patients with early‐stage disease. The multivariate Cox proportional risk regression model confirmed that a low H‐CXI negatively affected the prognosis of patients with cancer in the discovery cohort [hazard ratio (HR) 0.75, 95% confidence interval (CI) 0.71–0.80, P < 0.001], internal validation cohort (HR 0.79, 95 %CI 0.72–0.86, P < 0.001), external validation cohort (HR 0.84, 95% CI 0.79–0.89, P < 0.001) and total cohort (HR 0.80, 95% CI 0.77–0.83, P < 0.001). Multivariate logistic regression models showed that a low H‐CXI was an independent risk factor predicting adverse short‐term outcomes and cancer cachexia in patients with cancer. Conclusions The simple and practical H‐CXI is a promising predictor for cancer cachexia and prognosis in patients with cancer.

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Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study

Cited by 30 publications

References 42 publications

Mid-Arm Muscle Circumference or Body Weight-Standardized Hand Grip Strength in the GLIM Superiorly Predicts Survival in Chinese Colorectal Cancer Patients

Mid-Arm Muscle Circumference or Body Weight-Standardized Hand Grip Strength in the GLIM Superiorly Predicts Survival in Chinese Colorectal Cancer Patients

A Novel Inflammation and Insulin Resistance Related Indicator to Predict the Survival of Patients With Cancer

Hand grip strength‐based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer

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