Associations of Lifestyle, Medication, and Socio-Demographic Factors with Disability in People with Multiple Sclerosis: An International Cross-Sectional Study

Jelinek, George A; Livera, Alysha M De; Marck, Claudia H; Brown, Carolyn S.; Neate, Sandra L; Taylor, Keryn L; Weiland, Tracey J

doi:10.1371/journal.pone.0161701

Cited by 43 publications

(45 citation statements)

References 39 publications

(42 reference statements)

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“…Diet is a modifiable lifestyle factor, which can impact the severity of disability and relapses in MS patients (60). A poor diet is also associated with the development of metabolic disorders such as obesity and diabetes.…”

Section: Comorbiditiesmentioning

confidence: 99%

Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse

2017

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The autoimmune disease multiple sclerosis (MS) is characterized by relapses in the majority of patients. A definitive clinical diagnosis of relapse in MS can be complicated by the presence of an infection or comorbid disorder. In this mini-review, we describe efforts to develop enhanced imaging techniques and biomarker detection as future tools for relapse validation. There is emerging evidence of roles for meningeal inflammation, sex hormones, comorbid metabolic or mood disorders, and a dysregulated immune profile in the manifestation and severity of relapse. Specific subsets of immune cells likely drive the pathophysiology of relapse, and identification of a patient’s unique immunological signature of relapse may help guide future diagnosis and treatment. Finally, these studies highlight the diversity in terms of relapse presentation, immunological signature, and response in patients with MS, indicating that going forward the best approach to assessment and treatment of relapse will be multifactorial and highly personalized.

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Section: Comorbiditiesmentioning

confidence: 99%

Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse

2017

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“…56 ; Jelinek et al 52 ; Koriem 57 ; Malli et al 31 ; Masullo et al 13 ; Peterlik 58 ; Polachini et al 16 ; Romero et al 59 ; Schmitz et al 18 ; Shiri-Shahsavar et al 19 ; Torkildsen et al 20 63 ; Hoare et al 62 ; Mauriz et al 14 ; Nieto et al 15 ; Pantzaris et al 61 ; Rezapour-Firouzi et al 28 ; Rezapour-Firouzi et al 30 ; Schmitz et al 18 ; Shiri-Shahsavar et al 19 ; Timmermans et al 60 ; Weiland et al 43 Antioxidant Vitamins 12 19.0 Dorosty-Motlagh et al 9 ; Geldern; Mowry 10 ; Honarvar et al 11 ; Loken-Amsrud 12 ; Masullo et al 13 ; Mauriz et al 14 ; Nieto et al 15 ; Polachini et al 16 ; Saboor-Yaraghi et al 17 ; Schmitz et al 18 ; Shiri-Shahsavar et al 19 ; Torkildsen et al 20 Bioactive compounds 8 12. Hagan et al 35 ; Jelinek et al 36 ; Oliveira et al 37 ; Wens et al 38 .…”

Section: Resultsunclassified

“…There was also research 24,[33][34][35][36][37][38] on body size, evaluated through Body Mass Index (BMI) and Waist Circumference (WC) and more specifically on adiposity, which could contribute to MS incidence, the appearance of disabilities, development of Metabolic Syndrome and exacerbation of cardiovascular risk in diagnosed individuals. In 6.3% (n= 4) of studies, prevalence of vitamin B complex intake (folate, niacin and above all, cobalamin) was found among people diagnosed with this condition 13 , and the relation between these nutrients and etiology and pathology progression was studied 18,21,39 .…”

Section: Resultsmentioning

confidence: 99%

“…One of the hypothesis is that a higher BMI may intensify the proliferation of T helper 17 cells 34 or that it may be linked to a lower intestinal bacteria diversity 24 . Besides, adiposity assessed by BMI or the body composition may be directly or indirectly intermediated by insulin resistence 24,34 , thus exacerbating oxidative stress and inflammatory cytokine production, which may induce not just the development of MS but also an exacerbation of symptoms 36 . Therefore, deterioration in physical and mental health may happen due to any ponderal excess level according to BMI 37 .…”

Section: Discussionmentioning

confidence: 99%

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Nutrition in Multiple Sclerosis: An integrative review of scientific publications from the last 5 years

et al. 2019

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This study analyzed the profile of scientific production related to the nutritional aspects of the etiology and/or progress of Multiple Sclerosis (MS). We conducted an integrative review that analyzed 64 works published in English, Spanish or Portuguese between 2012 and 2017 on the relationship between nutrition and MS. There was a predominance of studies in humans (54.0%, n= 34) and randomized clinical trials (38.3%, n= 13). The association between vitamin D and etiology progression and/or development of disabilities resulting from MS was the most studied aspect (30.2%, n= 19), followed by studies that evaluated the importance of fat concentration and/or types for MS risk (22.2%, n= 14), and research that analyzed the role of antioxidant vitamins (19.0%; n= 12) in the disease development and/ or evolution. The study showed that most research involves small samples and that a healthy diet contributes to the prevention and mitigation of disease evolution. However, this affirmation cannot be made with regards to dietary supplements. Further research is necessary, from crosssectional studies to randomized clinical trials considering the wide knowledge gap on this subject.

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“…It is consistent with the findings that higher conscientiousness implies better organisational skills, deliberation and healthy behaviour, while lower conscientiousness correlates with impulsiveness and risky behaviour (smoking, alcohol etc.). This is important considering the results of a previous research that shows that smoking had been both a risk factor for developing MS and a cause of accelerating the progression of the illness (27,28).…”

Section: Discussionmentioning

confidence: 99%

The influence of personality traits and coping strategies on the quality of life of patients with relapsing-remitting type of multiple sclerosis

et al. 2021

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Introduction/Aim: Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system that can reduce the quality of life. Personality traits and coping strategies are a significant factor in interpersonal variance regarding quality of life. The aim of this study was to examine relations between personality traits and coping strategies in patients with relapsing-remitting (RR) type MS, and to examine relations of personality traits, coping strategies and quality of life in patients with RR type MS. Methodology: Observational cross-sectional study included 66 patients (34 female and 32 male) with clinically definitive MS, based on the McDonald criteria. The following clinical scales were used to examine personality traits, coping strategies and quality of life: Revised NEO Personality Inventory (NEO-PI-R), Coping Strategies Inventory (CSI) and Multiple Sclerosis Quality of Life (MSQOL-54). Results: The average age of the patients was 41.6 ± 7.1 years. Pearson correlation coefficient shows that with regards to coping strategies, the only positive relation exists with neuroticism (r=.502). The correlation is negative between neuroticism, passive coping strategies and quality of life with physical (r=-.284, p<0.05) and mental health (r=-.289, r=-0.358, p<0.05), meaning that the patients with a higher level of neuroticism, and who rely on passive coping strategies, have a worse quality of life. Conclusion: This research shows the importance of personality traits and coping strategy assessments in patients with RR type MS. Participation in cognitive-behavioral therapy, with an accent on active coping strategies, can improve the quality of life in patients with MS.

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Associations of Lifestyle, Medication, and Socio-Demographic Factors with Disability in People with Multiple Sclerosis: An International Cross-Sectional Study

Cited by 43 publications

References 39 publications

Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse

Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse

Nutrition in Multiple Sclerosis: An integrative review of scientific publications from the last 5 years

The influence of personality traits and coping strategies on the quality of life of patients with relapsing-remitting type of multiple sclerosis

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