Associations of leptin gene polymorphisms with production traits in pigs

Peixoto, J. de O.; Guimarães, Simone Eliza Facioni; Lopes, Paulo Sávio; Soares, Maria Amélia Menck; Pires, Aldrin Vieira; Barbosa, M V Gualberto; Torres, Robledo de Almeida; Silva, M de Almeida E

doi:10.1111/j.1439-0388.2006.00611.x

Cited by 44 publications

(23 citation statements)

References 12 publications

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“…Van der Lende et al (2005) reported that polymorphisms of LEP gene in pig were associated with a variation of the feed intake, ADG and BFT other than of reproductive traits. Conflicting results have been reported in association studies of LEP polymorphisms with the same phenotypic traits, and these probably depend from the experimental population used in the study (Jiang AND Gibson, 1999;Chen et al, 2004;Szydlowski et al, 2004;Stefanon et al, 2004;De Oliveira et al, 2006). Conflicting results for the SNPs of LEP gene were also observed in the present study.…”

Section: Resultscontrasting

confidence: 81%

Association Analysis between Single Nucleotide Polymorphisms in the Promoter Region ofLEP, MYF6, MYOD1, OPN, SCDGenes and Carcass Traits in Heavy Pigs

Guiatti

Sgorlon

Stefanon

2013

Italian Journal of Animal Science

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The purpose of the study was to evaluate associations between average daily gain (ADG) and DNA variability in the regulatory region of candidate genes in Italian Large White, Italian Duroc and Italian Landrace breeds for heavy pig production. The ADG of pigs was available as Estimated Breeding Values (EBVs) and Random Residuals (RRs). Within each breed, 200 individuals were sampled, 100 in the higher and 100 in the lower 5% tail of the normal distribution curve according to the EBVs for ADG of the populations (600 pigs overall). Six SNPs in promoter regions of 5 candidate genes (MYF6, MYOD1, OPN, SCD and two for LEP) were analysed. Allele frequencies were calculated and the SNPs for LEP, MYF6 and MYOD1 segregated in the 3 breeds, while polymorphisms in the OPN and SCD genes did not segregate in Italian Large White and Italian Landrace, and Italian Landrace respectively. Fisher's exact test (two-tailed) for the distribution of allele frequencies in minus and plus variant groups was significant for LEP_1 and MYOD1 in Italian Large White, for LEP_1, LEP_2, MYOD1, OPN and SCD in Italian Duroc and for LEP_1, LEP_2 and MYOD1 in Italian Landrace. Several putative binding sites were detected in the promoter regions using MATINSPECTOR software. Analysed mutations may affect putative core sequences of binding sites for transcription factors involved in muscle and fat tissues deposition. However, variations in binding affinities of the sequences related to the SNPs and the expected differential gene expression require to be evaluated.

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Section: Resultscontrasting

confidence: 81%

Association Analysis between Single Nucleotide Polymorphisms in the Promoter Region ofLEP, MYF6, MYOD1, OPN, SCDGenes and Carcass Traits in Heavy Pigs

Guiatti

Sgorlon

Stefanon

2013

Italian Journal of Animal Science

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“…A major focus for the discovery of polymorphisms in production animals has been to identify those associated with traits that are considered to be economically important such as lean muscle accretion, feed efficiency, and growth (Franco et al, 2005;de Oliveira Peixoto et al, 2006;Houston et al, 2006;Verner et al, 2007;Nie et al, 2008). Far fewer studies have identified polymorphisms associated with overall animal health, specifically as it relates to bone health.…”

Section: Discussionmentioning

confidence: 99%

A calcitonin receptor (CALCR) single nucleotide polymorphism is associated with growth performance and bone integrity in response to dietary phosphorus deficiency

Alexander

Cutler

et al. 2010

Journal of Animal Science

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Although concerns over the environmental impact of excess P in the excreta from pig production and governmental regulations have driven research toward reducing dietary supplementation of P to swine diets for over a decade, recent dramatic increases in feed costs have further motivated researchers to identify means to further reduce dietary P supplementation. We have demonstrated that genetic background impacts P utilization in young pigs and have identified genetic polymorphisms in several target genes related to mineral utilization. In this study, we examined the impact of a SNP in the calcitonin receptor gene (CALCR) on P utilization in growing pigs. In Exp. 1, 36 gilts representing the 3 genotypes identified by this CALCR SNP (11, 12, and 22) were fed a P-adequate (PA) or a marginally P-deficient (approximately 20% less available P; PD) diet for 14 wk. As expected, P deficiency reduced plasma P concentration, bone strength, and mineral content (P < 0.05). However, the dietary P deficiency was mild enough to not affect the growth performance of these pigs. A genotype × dietary P interaction (P < 0.05) was observed in measures of bone integrity and mineral content, with the greatest reduction in bone strength and mineral content due to dietary P deficiency being associated with the allele 1. In Exp. 2, 168 pigs from a control line and low residual feed intake (RFI) line were genotyped for the CALCR SNP and fed a PA diet. As expected, pigs from the low RFI line consumed less feed but also gained less BW when compared with the control line (P < 0.05). Although ADFI did not differ between genotypes, pigs having the 11 genotype gained less BW (P < 0.05) than pigs having the 12 or 22 genotypes. Pigs of the 11 and 12 genotypes had bones that tolerated greater load when compared with animals having the 22 genotype (P < 0.05). A similar trend was observed in bone modulus and ash % (P < 0.10). These data are supportive of the association of this CALCR SNP with bone integrity and its response to dietary P restriction. Although the allele 1 is associated with greater bone integrity and mineral content during adequate P nutrition, it is also associated with the greatest loss in bone integrity and mineral content in response to dietary P restriction. Understanding the underlying genetic mechanisms that regulate P utilization may lead to novel strategies to produce more environmentally friendly pigs. ABSTRACT: Although concerns over the environmental impact of excess P in the excreta from pig production and governmental regulations have driven research toward reducing dietary supplementation of P to swine diets for over a decade, recent dramatic increases in feed costs have further motivated researchers to identify means to further reduce dietary P supplementation. We have demonstrated that genetic background impacts P utilization in young pigs and have identified genetic polymorphisms in several target genes related to mineral utilization. In this study, we examined the impact of a SNP in the calcitonin receptor ge...

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“…Peixoto et al (2006). A genotipagem foi realizada via tecnologia Golden Gate/Vera Code R, no Laboratório de Genética Animal, da Embrapa Recursos Genéticos e Biotecnologia, Brasília, DF, conforme descrito por Paixão et al (2011).…”

Section: Introductionunclassified

Regressão via componentes independentes aplicada à seleção genômica para características de carcaça em suínos

Azevedo

Resende

Silva

et al. 2013

Pesq. agropec. bras.

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Resumo -O objetivo deste trabalho foi avaliar a eficiência do método de regressão via componentes independentes (ICR) na estimação de valores genéticos genômicos e dos efeitos de marcadores SNP para características de carcaça de uma população F 2 de suínos (Piau x linhagem comercial). Os métodos foram avaliados por meio da concordância entre os valores genéticos preditos e os fenótipos corrigidos, observados por validação cruzada, e também foram comparados com outros métodos geralmente utilizados para os mesmos propósitos, tais como RR-BLUP, PCR e PLS. Os métodos ICR e PCR apresentam resultados similares, mas o método ICR apresenta maiores valores de acurácia.Termos para indexação: Sus scrofa, BLUP, marcadores SNP, regressão aleatória, redução dimensional. Independent component regression applied to genomic selection for carcass traits in pigsAbstract -The objective of this work was to evaluate the efficiency of the independent component regression (ICR) method for the estimation of genomic values and of SNP marker effects for carcass traits in a F 2 pig population (Piau x commercial line). The methods were evaluated by the agreement between the genetic predicted values and the corrected phenotypes observed by cross-validation, and they were also compared with other methods generally used for the same purposes, such as RR-BLUP, PCR, and PLS. The ICR and PCR methods show similar results, but ICR has the highest accuracy prediction values.

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Associations of leptin gene polymorphisms with production traits in pigs

Cited by 44 publications

References 12 publications

Association Analysis between Single Nucleotide Polymorphisms in the Promoter Region ofLEP, MYF6, MYOD1, OPN, SCDGenes and Carcass Traits in Heavy Pigs

Association Analysis between Single Nucleotide Polymorphisms in the Promoter Region ofLEP, MYF6, MYOD1, OPN, SCDGenes and Carcass Traits in Heavy Pigs

A calcitonin receptor (CALCR) single nucleotide polymorphism is associated with growth performance and bone integrity in response to dietary phosphorus deficiency

Regressão via componentes independentes aplicada à seleção genômica para características de carcaça em suínos

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