Associations of interleukin (IL)-1β, IL-1 receptor antagonist, and IL-10 with dental caries

Çoğulu, Dilşah; Önay, Hüseyin; Özdemi̇r, Yavuz; Aslan, Gulcin Itirli; Özkınay, Ferda; Kütükçüler, Necil; Eronat, Cemal

doi:10.2334/josnusd.57.31

Cited by 32 publications

(34 citation statements)

References 33 publications

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“…Proteins such as lysozymes, interleukins, mucins, and lactotransferrin (LTF) can promote cell aggregation, inhibition, and/or bacterial adherence. 4,5,6,7 Other proteins, such as beta defensins, have…”

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Salivary protein polymorphisms and risk of dental caries: a systematic review

et al. 2017

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Dental caries is an oral pathology associated with both lifestyle and genetic factors. The caries process can be influenced by salivary composition, which includes ions and proteins. Studies have described associations between salivary protein polymorphisms and dental caries experience, while others have shown no association with salivary proteins genetic variability. The aim of this study is to assess the influence of salivary protein polymorphisms on the risk of dental caries by means of a systematic review of the current literature. An electronic search was performed in PubMed, Scopus, and Virtual Health Library. The following search terms were used: "dental caries susceptibility," "dental caries," "polymorphism, genetics," "saliva," "proteins," and "peptides." Related MeSH headings and free terms were included. The inclusion criteria comprised clinical investigations of subjects with and without caries. After application of these eligibility criteria, the selected articles were qualified by assessing their methodological quality. Initially, 338 articles were identified from the electronic databases after exclusion of duplicates. Exclusion criteria eliminated 322 articles, and 16 remained for evaluation. Eleven articles found a consistent association between salivary protein polymorphisms and risk of dental caries, for proteins related to antimicrobial activity (beta defensin 1 and lysozyme-like protein), pH control (carbonic anhydrase VI), and bacterial colonization/adhesion (lactotransferrin, mucin, and proline-rich protein Db). This systematic review demonstrated an association between genetic polymorphisms and risk of dental caries for most of the salivary proteins.

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Salivary protein polymorphisms and risk of dental caries: a systematic review

et al. 2017

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“…Prso et al reported that patients with periapical root lesions had higher IL levels than the control group (28). There are studies indicating that there is a relationship between tooth decay and cytokines and there are other studies that indicate otherwise (4,29).…”

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confidence: 99%

“…Even though the interactions between pathological (acidogenic bacteria, fermentable carbohydrates) and protective factors (saliva components: proteins, fluoride, calcium, phosphate), are complex, the disease can easily be prevented if the dynamic balance between the protective and pathological factors can be kept in equilibrium (3,5,6). Mutans streptococci, and Lactobacilli are the two important caries associated acidogenic bacteria of dental caries (1,4). An increase in the numbers of S. Mutans in saliva is associated with caries initiation where as an increase in the number of lactobacilli indicates progressed lesions of caries (7).…”

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“…Recent studies show that cytokines are important in regulating the inflammatory response to bacterial infection (4,11,14,(17)(18)(19)(20)(21). Cytokines role in dental caries formation is not yet fully understood.…”

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confidence: 99%

“…Cytokines role in dental caries formation is not yet fully understood. However, investigators are aware of the fact that S. mutans found in the mouth stimulate pro-inflammatory cytokines (4,22). It has been reported that the cytokines levels (TNF-α, IL-6 and IL-8) are significantly increased in the saliva of those with dental caries compared to those without (15,23,24).…”

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Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study

Pakdemirli

Koçal

Kılınç

et al. 2020

J Basic Clin Health Sci

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Objectives: Objective of this study is to determine the correlation between salivary cytokine concentrations and cariogram value high (C1) and low (C2) experience in people. In this direction, saliva cytokines showed a significant correlation with the patient's caries experience. Patients and Methods: Unstimulated whole saliva samples were collected from 38 appropriate populations of patients aged between 20 to 57 years old. All patients' DMF (decay/missing/filled) values were higher than 0. Twenty-one caries activity groups (C1) and 17 caries nonactivity groups (C2) patients were collected for this study. Procedures of the clinical evaluation were the collection of saliva samples and oral examination. The whole saliva from 38 patients with C1 and C2 was investigated for the existence of GM-CSF,

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A double‐blind randomized clinical trial of inflammatory cytokine and pepsin levels in the saliva of patients with voice prostheses

Żurek,

Czesak,

Czerwińska

et al. 2024

Head & Neck

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BackgroundTracheoesophageal speech is one of the most effective method used for voice rehabilitation after laryngectomy. The main limitation is the need for periodic voice prothesis (VP) replacements. The process of developing VP usage complications is still unexplored. The aim of this study was to assess the level of cytokines (IL‐1β, IL‐6, IL‐8, IL‐10, TNFα) and pepsin in saliva as potential factors reducing VP longevity.MethodsProspective double‐blind randomized clinical trial was conducted (NCT04268459). Patients were randomly divided into two groups depending on VP replacement regimen (regular—every 3 months, or irregular—when complications occur). Levels of IL‐1β, IL‐6, IL‐8, IL‐10, TNFα, and pepsin in saliva samples (fasting and after eating) of laryngectomized patients were measured using ELISA tests.ResultsFifty‐two patients (26 in both groups) with control group (7 patients) participated in the study. The level of IL‐1β, IL‐6, IL‐8, IL‐10, TNFα, and pepsin did not differ according to regularity of VP replacements (p = 0.301–0.801). IL‐6 levels were significantly higher when VP complications occurs (p = 0.012).ConclusionsThe saliva components were not significantly different depending on the frequency of VP replacements. IL‐6 plays an important role in the development of VP use complications.

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Associations of interleukin (IL)-1β, IL-1 receptor antagonist, and IL-10 with dental caries

Cited by 32 publications

References 33 publications

Salivary protein polymorphisms and risk of dental caries: a systematic review

Salivary protein polymorphisms and risk of dental caries: a systematic review

Salivary Pro-Inflammatory Cytokines and Salivary Bacterial Challenge Effect on Dental Caries: A Clinico-Molecular Cross-Sectional Study

A double‐blind randomized clinical trial of inflammatory cytokine and pepsin levels in the saliva of patients with voice prostheses

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