Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population

Association of MIF promoter polymorphisms with psoriasis in a Han population in northeastern China

“…Studies have reported that polymorphisms were not associated with susceptibility to psoriasis, but that they might be important for the age of onset [16,17]. In our study, by analyzing further the distribution of MIF promoter polymorphisms in psoriasis subgroups, we found that À173C was a risk factor for late onset psoriasis (P = 0.02).…”

Genetics of Psoriasis and Pharmacogenetics of Biological Drugs

“…In a Korean population (114 patients and 281 controls), the rs2069762 (G allele) in IL2 conferred a risk of psoriasis, mainly in the late-onset group (Table 1) [53]. As for INF γ , rs2430561 has been associated with susceptibility to psoriasis (78 cases versus 74 controls) (Table 1) [54].…”

“…A study performed in 114 psoriasis patients and 281 controls from Korea showed that rs2069762 (G allele) in IL2 conferred a risk of developing the disease, mainly in late-onset psoriasis (Table 1) [53]. Moreover, the cytokines IL6 and IL10 seem to be important in the development of psoriasis [59].…”

Influence of functional genetic polymorphism (−590C/T) in non-small cell lung cancer (NSCLC) development: The paradoxal role of IL-4

“…The T allele increases IL-4 expression and is associated with elevation of total serum levels of IL-4, whereas the C allele is associated with lower gene expression (Rosenwasser et al, 1995). The frequencies of the T "high expression" allele range between 70% and 85% in Asians and 15% and 25% in Europeans (Anovazzi et al, 2010;Chiang et al, 2007;Gyan et al, 2004;Hegab et al, 2004;Heward et al, 2001;Holla et al, 2008;Huang et al, 2008;Kawashima et al, 1998;Kim et al, 2007;Landi et al, 2007;Nunez et al, 2008;Rosenwasser et al, 1995;Tangteerawatana et al, 2007;Tsezou et al, 2008;Vairaktaris et al, 2007;Yannopoulos et al, 2007;Zhu et al, 2010). This allele has been associated with some types of cancer (Huang et al, 2008;Vairaktaris et al, 2007;Varin and Gordon, 2009).…”