Associations ofβ-Cell Function and Insulin Resistance with Youth-Onset Type 2 Diabetes and Prediabetes Among Asian Indians

Abstract

Among Asian Indians, β-cell dysfunction appears to be more strongly associated with T2DM-Y than insulin resistance.

Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians

“…Studies have suggested that there could be an accelerated beta cell dysfunction in younger age groups, thus shortening the transition time between prediabetes and T2DM-Y [13,30]. Two recent cross-sectional studies indicate that Asian Indians may be susceptible to early decline in beta cell function even during stages of mild dysglycemia [31,32]. In this context, this study assumes significance as we report decreased betatrophin levels in Asian Indians with T2DM-Y.…”

Secreted Frizzled-Related Protein 4 (SFRP4): A Novel Biomarker of β-Cell Dysfunction and Insulin Resistance in Individuals With Prediabetes and Type 2 Diabetes

“…Cross-sectional studies indicate that Asian Indians may be susceptible to early decline in b-cell function even during stages of mild dysglycemia (4,5). In this context, this study assumes significance as we report increased SFRP4 levels in Asian Indians even at the stage of IGT.…”

Role of various indices derived from an oral glucose tolerance test in the prediction of conversion from prediabetes to type 2 diabetes

“…The b-cell-related indices were significantly decreased in diabetes converters, while insulin resistance-related parameters did not differ between converters and nonconverters. Several studies have shown that b-cell dysfunction is the major driving factor for the development of overt diabetes in Asians, Pima Indians, and Caucasians [27][28][29][30][31][32]. Differences in underlying b-cell function in each prediabetes category might contribute to the heterogeneous rate of progression to diabetes.…”