Associations of<i>KCNQ1</i>Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An Updated Meta-Analysis with Trial Sequential Analysis

Yu, Xiaoxuan; Liao, Minqi; Zeng, Yufei; Gao, Xu; Liu, Yanhua; Sun, Wei; Zhu, Shuang; Zeng, Fangfang; Ye, Yan-Bin

doi:10.1155/2020/7145139

Cited by 12 publications

(23 citation statements)

References 52 publications

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“…The SNP rs163184 locus is contiguous to rs2237892 and rs2237895, which are in moderate linkage disequilibrium with each other 22 . Overall, these findings suggest that the KCNQ1 variants associated with the ACC haplotype affect the expression of other target genes and/or the transcription of the nearby imprinting region, encompassing CDKN1C , PHLDA2 , and Slc22a18, which are related to β-cell proliferation 23 – 26 . Based on our results, further studies are required to validate the correlation and to investigate the effects of KCNQ1 variants within introns that potentially regulate β-cell proliferation or a functional modification of the KvLQT1 channel.…”

Section: Discussionmentioning

confidence: 87%

Synergistic effect between the KCNQ1 haplotype and alcohol consumption on the development of type 2 diabetes mellitus in Korean cohorts

Park

Yoo

Yun

et al. 2021

Sci Rep

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Potassium voltage-gated channel subfamily Q member 1 (KCNQ1) is one of the strongest susceptibility genes for type 2 diabetes mellitus (T2DM). Association studies between KCNQ1 genetic variants and T2DM have been reported. The multifactorial disease T2DM is caused by interactions between genetic susceptibility and environmental factors. In this study, we examined the associations between the KCNQ1 haplotype, which consists of the major alleles rs3852528, rs11024175, and rs2237892 (ht: ACC), and environmental factors such as alcohol consumption, which are related to the risk of T2DM, in two independent Korean populations. Data from health examination studies, i.e., HEXA (n = 50,357 subjects) and the Ansung–Ansan community-based Korean cohort study (n = 7603), were analyzed. In both cohorts, fasting blood glucose levels were significantly increased in moderate-to-heavy drinkers and carriers of the homozygous ACC haplotype. A significant association between the KCNQ1 haplotype and alcohol consumption in the risk of diabetes was observed in the HEXA (OR 1.587; 95% CI 1.128–2.234) and Ansung–Ansan (OR 2.165; 95% CI 1.175–3.989) cohorts compared with abstainers not carrying the KCNQ1 haplotype. Associations of the KCNQ1 haplotype with alcohol consumption and β-cell function were observed in the Ansung–Ansan cohort. Moderate-to-heavy drinkers with the ACC haplotype had lower fasting insulin levels and mean 60 min insulinogenic index (IGI60) compared with light drinkers and abstainers not carrying the ACC haplotype. These findings indicate that KCNQ1 variants play a synergistic role with alcohol consumption in the development of T2DM and impaired β-cell function.

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Section: Discussionmentioning

confidence: 87%

Synergistic effect between the KCNQ1 haplotype and alcohol consumption on the development of type 2 diabetes mellitus in Korean cohorts

Park

Yoo

Yun

et al. 2021

Sci Rep

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“…Previously, a meta-analysis was performed in 2012 to investigate the association between KCNQ1 rs2237892 polymorphism and T2DM risk; however, only 25 articles were included in the analysis. Recently, a meta-analysis was performed to investigate the relationship between several KCNQ1 SNPs and T2DM risk, and a significant relationship between KCNQ1 polymorphism rs2237892 and T2DM risk was found [ 63 ]. However, the analysis was limited to 38 articles and incomplete sample size as well as selective bias are potential limitations of that study [ 63 ] (Fig.…”

Section: Discussionmentioning

confidence: 99%

Effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus: An updated meta-analysis

Jiang

Deng

et al. 2021

Diabetol Metab Syndr

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Objectives Previous studies have analyzed the potential effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus, but the findings are inconclusive and the subject of debate. The purpose of our study was to provide further insight into the potential association between KCNQ1 rs2237892 polymorphism and the risk of type 2 diabetes mellitus. Methods In total, 50 articles (60 studies) with 77,276 cases and 76,054 controls were utilized in our analysis. The pooled odds ratio (OR), 95% confidence interval (95% CI), and p value were used to evaluate the significance of our findings. Funnel plots and Beggar’s regression tests were utilized to determine the presence of publication bias. Results Our meta-analysis results indicated that KCNQ1 rs2237892 polymorphism could be correlated with the risk of type 2 diabetes mellitus under the C allelic, recessive, and dominant genetic models (OR = 1.25, 95% 1.19–1.32, p < 0.001; OR = 1.50, 95% CI 1.34–1.68, p < 0.001; OR = 1.26, 95% CI 1.14–1.40, p < 0.001, respectively). Additionally, ethnicity analysis revealed that the source of control, case size, and Hardy–Weinberg Equilibrium status were correlated to the polymorphism in the three genetic models. Conclusions Our meta-analysis demonstrated significant evidence to support the association between KCNQ1 rs2237892 polymorphism and predisposition to type 2 diabetes mellitus.

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“…Email: shaimabbasd@yahoo.com further demonstrate whether genetic factors play a vital role in the pathogenesis of T2DM (4) or not.…”

Section: Corresponding Author: Shaimaa Abbas Dawoodmentioning

confidence: 95%

“…The transcription factor KLF14, is a master trans-regulator of multiple genes that are associated with metabolic phenotypes in adipose tissue, KLF14, is located on chromosome 7q32.3. Variations in these genes are associated with T2DM (4) .…”

Section: Corresponding Author: Shaimaa Abbas Dawoodmentioning

confidence: 99%

Determination the Relationship between (KLF14 rs972283) Genotype and Type 2 Diabetes in a Sample of Iraqi Patients

Shaimaa Abbas Dawood,

Mohammed Ibrahim Nader

2021

Indian Journal of Forensic Medicine & Toxicology

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This study was aimed to detect KLF14 gene polymorphism in Iraqi type 2 diabetes mellitus patients (T2DM) to found the correlation between the SNP (rs972283) polymorphism in KLF14 gene and lipid metabolism and impact on the incidence of type 2 diabetes mellitus (T2DM). The result show high Significant difference was observed in FBS level (P<0.001) in patient group (172.9 ± 79.73) and in control (81.16 ± 7.18),). Cholesterol, LDL-Cholesterol and VLDL-Cholesterol mean level value in diabetic patients was significantly higher than those of control group (p<0.0001), serum HDL-Cholesterol mean value was significantly difference (P<0.05) in serum mean level of HDL between T2DM patients and healthy controls. Real time PCR (HRM) RT-PCR were used to detect SNP (rs972283) in KLR14 gene (G>A) by using specific primers, as a related with SNP (rs972283) G>A in KLF14 gene, genotypes and alleles frequencies, odds ratios, 95% confidence intervals and P values for the KLF14 gene In this study, statistical analyses of genotypic frequencies for the KLF14 (rs972283) revealed significant difference between T2DM patients and controls in the examined population. GG genotype was significantly (P = 0.0006) more frequent in the patient group. The observed G/G, A/G, and A/A genotype frequencies were 50%, 42%, and 8%, re spectively .The A (wildtype) and G (variant) allele frequencies were 29% and 71% , respectively in patient group while the observed G/G, A/G, and A/A genotype frequencies were 22%, 48%, and 30, re spectively and the A (wild-type) , G (variant) allele frequencies were 54% and 46%, respectively in control group (P <0.0003). GG genotype was significantly (P = 0.0006) more frequent in the patient group, Conclusion: There was a relationship between polymorphism of KLF14 gene SNP (rs972283) and the incidence of T2DM in sample of Iraqi patients.

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Associations ofKCNQ1Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An Updated Meta-Analysis with Trial Sequential Analysis

Cited by 12 publications

References 52 publications

Synergistic effect between the KCNQ1 haplotype and alcohol consumption on the development of type 2 diabetes mellitus in Korean cohorts

Synergistic effect between the KCNQ1 haplotype and alcohol consumption on the development of type 2 diabetes mellitus in Korean cohorts

Effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus: An updated meta-analysis

Determination the Relationship between (KLF14 rs972283) Genotype and Type 2 Diabetes in a Sample of Iraqi Patients

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