Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All‐Cause Mortality in Adults: A Cohort Study

Abstract

Background Limited studies have involved new‐onset hypertriglyceridemia, and this study was to evaluate the associations of hypertriglyceridemia onset age with cardiovascular diseases (CVD) and all‐cause mortality. Methods and Results This population‐based prospective study enrolled 98 779 participants free of hypertriglyceridemia and CVD at baseline in the Kailuan study initiated in June 2006. All participants underwent health checkups biennially until December 2017, and a total of 13 832 participants developed new hypertriglyceridemia. A 1:1 age‐ (±1 year) and sex‐matched analysis was applied to select control subject of the same year for each new‐onset case. There were 13 056 case‐control pairs included. The total follow‐up time was 179 409 person‐years, with a median follow‐up time of 7.0 years. Primary outcomes were CVD and all‐cause mortality, and hazard ratios were estimated after adjustment for baseline characteristics. A total of 807 incident CVD events and 600 all‐cause mortality events were documented. After multivariable adjustment, participants with hypertriglyceridemia onset age <45 years had the highest risk compared with matched controls, with hazard ratios of 2.61 (95% CI, 1.59–4.27) for CVD, 4.69 (95% CI, 2.34–9.40) for all‐cause mortality, 2.23 (95% CI, 0.67–7.38) for myocardial infarction, and 2.68 (95% CI, 1.56–4.62) for stroke. The risk estimates gradually decreased with each decade increase in the onset age of hypertriglyceridemia. Conclusions Among Chinese adults, hypertriglyceridemia identified at an earlier onset age was associated with higher risks for CVD and all‐cause mortality.

Protocol for evaluating the effects of the Reducing Cardiometabolic Diseases Risk dietary pattern in the Chinese population with dyslipidaemia: a single-centre, open-label, dietary intervention study

“…In Tianjin, 100 eligible participants aged 35–45 years with dyslipidaemia will be recruited. Enhanced management of dyslipidaemia in this age group may better reduce the risk of incident CVD and diabetes and contribute to the primary prevention of CMDs 20–22. Participants will be randomised and allocated into the RCMDR dietary pattern intervention group or the general health education control group, with 50 participants in each group.…”

“…Enhanced management of dyslipidaemia in this age group may better reduce the risk of incident CVD and diabetes and contribute to the primary prevention of CMDs. [20][21][22] Participants will be randomised and allocated into the RCMDR dietary pattern intervention group or the general health education control group, with 50 participants in each group. After a 1-week run-in period, participants in the intervention group will receive free standard breakfasts and lunches and dietary guidance based on the RCMDR dietary pattern.…”

Multi-trajectories of triglyceride-glucose index and lifestyle with Cardiovascular Disease: a cohort study

“…Participants were recruited from the Kailuan Study, a prospective cohort conducted at Kailuan General Hospital and its 10 affiliated hospitals. The study details have been previously described [ 14 ]. Briefly, participants from the Kailuan community completed the initial survey through face-to-face interviews between June 2006 and October 2007, followed by biennial follow-ups.…”

Hubungan Antara Pola Makan Dan Kondisi Penyerta Dengan Prevalensi Strok Pada Usia Dewasa Di Indonesia: Analisis Data Riskesdas 2018

“…11 Peningkatan profil lipid darah, salah satunya kadar kolesterol juga dapat menyebabkan terjadinya aterosklerosis kemudian berdampak strok. 12 Penelitian lain pada pasien dewasa menunjukkan bahwa diabetes melitus berisiko 3,224 kali lebih besar terhadap strok. 13 Beberapa penelitian telah dilakukan untuk melihat faktor risiko yang berkaitan dengan penyakit strok di Indonesia.…”