Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers

Gorusupudi, Aruna; Liu, Aihua; Hageman, Gregory S.; Bernstein, Paul S.

doi:10.1194/jlr.p065540

Cited by 61 publications

(53 citation statements)

References 41 publications

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“…They found that RBC lipids correlated very well with retinal lipid in human eyes and are indeed excellent biomarkers of retinal lipid content. Eyes from AMD donors had significantly decreased levels of very long-chain PUFAs and low n-3/n-6 ratios [50] , which was consistent with a study showing that AMD patients had a low serum DHA/ARA ratio compared to healthy individuals [52] . All these results support the notion from the NAT-2 study that maintaining a high EPA plus DHA index (Omega-3 Index, O3I) is important in reducing the risk of neovascular AMD.…”

Section: Age-related Macular Degenerationsupporting

confidence: 78%

“…Using RBCs is more reliable than plasma in evaluating n-3 fatty acid status, since clinical studies have shown that levels in RBCs are biologically less variable and a better biomarker for estimated chronic n-3 fatty acid status [48,49] . Lipid levels in RBCs were shown to correlate very well with lipid levels in retina [50] .…”

Section: Age-related Macular Degenerationmentioning

confidence: 87%

“…Not only was dietary oily fish and seafood consumption significantly lower in patients with AMD than in controls, but RBC EPA and EPA + DHA were associated with a substantially and significantly lower risk of neovascular AMD (odds ratio 0.25, 95% CI 0.13-0.47, p < 0.0001, and odds ratio 0.52, 95% CI 0.29-0.94, p = 0.03, respectively) [45,51] . A recent study examined 2 independent cohorts of donor eyes from AMD patients and control subjects and related their retinal lipid profiles with systemic biomarkers of lipid intake [50] . They found that RBC lipids correlated very well with retinal lipid in human eyes and are indeed excellent biomarkers of retinal lipid content.…”

Section: Age-related Macular Degenerationmentioning

confidence: 99%

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The Role of Fish Oil in Inflammatory Eye Diseases

Wang

Daggy

2017

Biomed Hub

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Consumption of fish oil is associated with reduced morbidity and mortality of cardiovascular diseases and also reduces the severity of many other inflammatory diseases and autoimmune disorders. The beneficial effects are attributed to the anti-inflammatory effects of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oils. The mechanism of the anti-inflammatory effects was long thought to be by modulating the production of proinflammatory mediators, including prostaglandins, thromboxanes, and leukotrienes. Recent advances in research into the novel lipid mediators (resolvins, protectins, and maresins) derived from EPA and DHA and their role in the resolution of inflammation have shed new light on the pleiotropic nature of these fatty acids. In this review, we focus on the effects of EPA and DHA from fish oil in the treatment of two common inflammatory eye diseases - dry eye disease and age-related macular degeneration. Evidence from recent studies lends support to a role of fish oil in the treatment of these two eye diseases.

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Section: Age-related Macular Degenerationsupporting

confidence: 78%

Section: Age-related Macular Degenerationmentioning

confidence: 87%

Section: Age-related Macular Degenerationmentioning

confidence: 99%

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The Role of Fish Oil in Inflammatory Eye Diseases

Wang

Daggy

2017

Biomed Hub

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“…Koto et al (136) suggested that an EPA-rich diet resulted in significant suppression of neovascularization, although some studies reported no such relation (127). Studies from our laboratory indicate that serum and retinal EPA:arachidonic acid and n-3:n-6 LC-PUFA ratios were significantly lower in AMD donor eyes than they were in age-matched control subjects (137). Studies support the potential role of n-3 LC-PUFAs in the prevention of late AMD and highlight the necessity of clinical studies to determine more accurately the value of n-3 LC-PUFAs as a means of reducing the incidence of AMD (71, 72, 122, 134, 138).…”

Section: Introductionmentioning

confidence: 66%

The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration

Gorusupudi

Nelson

Bernstein

2017

Advances in Nutrition

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Age-related macular degeneration (AMD) is one of the leading causes of vision loss in the elderly. With an increasingly aged population worldwide, the need for the prevention of AMD is rising. Multiple studies investigating AMD with the use of animal models and cell culture have identified oxidative stress-related retinal damage as an important contributing factor. In general, diet is an excellent source of the antioxidants, vitamins, and minerals necessary for healthy living; moreover, the general public is often receptive to recommendations made by physicians and health care workers regarding diet and supplements as a means of empowering themselves to avoid common and worrisome ailments such as AMD, which has made epidemiologists and clinicians enthusiastic about dietary intervention studies. A wide variety of nutrients, such as minerals, vitamins, v-3 (n-3) fatty acids, and various carotenoids, have been associated with reducing the risk of AMD. Initial results from the Age-Related Eye Disease Study (AREDS) indicated that supplementation with antioxidants (b-carotene and vitamins C and E) and zinc was associated with a reduced risk of AMD progression. The AREDS2 follow-up study, designed to improve upon the earlier formulation, tested the addition of lutein, zeaxanthin, and v-3 fatty acids. In this review, we examine the science behind the nutritional factors included in these interventional studies and the reasons for considering their inclusion to lower the rate of AMD progression. Adv Nutr 2017;8:40-53.

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“…The administration of a daily dose of EPA (350 mg) and DHA (650 mg) for 3 years has been shown to lower the risk of CNV in patients with early lesions of AMD, steadily achieving the highest tertile of omega-3 long-chain PUFAs in their red blood cell membranes (Souied et al, 2013). As long-term biomarkers of omega-3 long-chain PUFAs (Gorusupudi et al, 2016), red blood cell membranes with increased content of EPA and DHA (and plasma EPA) after dietary intake of seafoods are associated with a lower risk for neovascular AMD (Merle et al, 2014). The combination of omega-3 long-chain PUFAs with intravitreal anti-vascular endothelial growth factor (VEGF) treatment also decreases vitreous VEGF-A levels in patients with AMD (Rezende et al, 2014).…”

Section: Dietary Fatty Acids In Age-related Macular Degenerationmentioning

confidence: 99%

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration

et al. 2017

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SUMMARY:Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. This review summarizes the effects of dietary omega-3 long-chain PUFAs, MUFAs, and SFAs, and lipoproteins on AMD. Findings are consistent with the beneficial role of dietary omega-3 long-chain PUFAs, while the effects of dietary MUFAs and SFAs appeared to be ambiguous with respect to the possible protection from MUFAs and to the possible adverse impact from SFAs on AMD. Some of the pathological mechanisms associated with lipoproteins on AMD share those observed previously in cardiovascular diseases. It was also noticed that the effects of FAs in the diet and lipoprotein on AMD could be modulated by genetic variants. From a population health perspective, the findings of this review are in favour of omega-3 long-chain FAs recommendations in a preventive and therapeutic regimen to attain lower AMD occurrence and progression rates. Additional long-term and short-term nutrigenomic studies are required to clearly establish the role and the relevance of interaction of dietary FAs, lipoproteins, and genes in the genesis and progression of AMD. KEYWORDS: Age-related macular degeneration; Dietary fats; Fatty acids; Lipoproteins; Olive oil; RetinaRESUMEN: Efecto de los ácidos grasos y lipoproteínas de la dieta sobre la progresión de la degeneración macular relacionada con la edad. La degeneración macular asociada a la edad (DMAE) es una condición patológica caracterizada por pérdida de visión central y ceguera. Numerosos estudios han revelado que ciertos cambios en los ácidos grasos de la dieta podrían tener efectos beneficiosos en el manejo de la DMAE. En esta revisión se recogen los efectos de los ácidos grasos de la dieta poliinsaturados omega-3, monoinsaturados y saturados, y de las lipoproteínas en la DMAE. La literatura es consistente en el papel beneficioso de los ácidos grasos polinsaturados omega-3 de cadena larga, mientras que se muestra ambigua con los efectos de los ácidos grasos monoinsaturados y saturados de la dieta, respecto al posible papel protector de los ácidos grasos monoinsaturados como al posible efecto adverso de los ácidos grasos saturados en la DMAE. Además algunos mecanismos patológicos que asocian las lipoproteínas con la DMAE son los mismos observados previamente en las enfermedades cardiovasculares. Hacen falta estudios nutrigenómicos a corto y largo plazo para establecer el papel y la importancia de los ácidos grasos de la dieta, y las lipoproteínas en la aparición y progresión de la DMAE.PALABRAS CLAVE: Aceite de oliva; Ácidos grasos; Degeneración macular asociada a la edad; Grasas de la dieta; Lipoproteínas; Retina ORCID ID: Montserrat-de la Paz S http://orcid.org/0000-0001-5400-3192, Naranjo MC http://orcid.org/0000-0002-1516-8098, Bermúdez B http://orcid.org/0000-0002-7429-6567, López S http://orcid.org/0000-0001-5952-3568, Abia R http://orcid.org/0000-0003-2741-189...

show abstract

Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers

Cited by 61 publications

References 41 publications

The Role of Fish Oil in Inflammatory Eye Diseases

The Role of Fish Oil in Inflammatory Eye Diseases

The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration

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