Associations of Homocysteine with B Vitamins and Zinc in Serum Levels of Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Abstract

The association of homocysteine metabolism-related nutrients along with renal function to homocysteine levels is not well known in patients with type 2 diabetes mellitus (T2DM). We investigated the relevance of kidney function, albuminuria, and nutritional factors to serum homocysteine in T2DM patients. This cross-sectional study enrolled 149 T2DM patients (96 men and 53 postmenopausal women), and patient characteristics and laboratory data including kidney-related data [glomerular filtration rate (eGFR), urinary albumin excretion (UACR), uric acid] and metabolism parameters (hemoglobin A1c and lipids) were collected from the medical record and serum levels of vitamin B12, folic acid, zinc, homocysteine and UACR were also acquired. In total subjects, serum levels of homocysteine, vitamin B12, and folic acid were within reference intervals, but zinc levels were close to lower limits of its reference interval. A multivariate-adjusted analysis showed that gender (b520.259, p,0.001), uric acid (b50.267, p,0.001), eGFR (b520.188, p50.001), log UACR (b50.190, p50.002), log folic acid (b520.259, p,0.001), log vitamin B12 (b520.224, p,0.001) and zinc (b520.169, p50.006) were correlated to log homocysteine. In multiple regression analysis by gender, these correlations were found similarly in men, but neither log folic acid nor zinc showed correlations with log homocysteine in women. The present study suggests that renal function parameters and the certain nutritional factors have a possible influence on serum homocysteine, in T2DM patients including diabetes kidney disease.

Association between Micronutrients and Hyperhomocysteinemia: A Case-Control Study in Northeast China

“…However, there are few studies that have elucidated whether minerals are relevant factors influencing Hcy metabolic enzymes. Sadako Matsui's [30] cross-sectional study showed that Zn was negatively correlated to log Hcy in men, but not in women. Esfandiar Heidarian [31] conducted a randomized, double-blind, controlled, crossover study which showed that Zn supplementation reduced serum Hcy and increased vitamin B12 and fol concentrations in T2DM patients with microalbuminuria.…”