Associations of HLA-C Alleles With Multinodular Goiters

Associations between HLA-C alleles and papillary thyroid carcinoma

“…Also in another study the absence of the HLA-Cw4 allele was associated with goiters presenting with an intrathoracic component and greater weight [23]. The HLA-Cw1 was associated with the presence of goiter-associated thyroid carcinoma [23]. In addition, associations were found between HLA-Cw1 and the presence of vascular involvement and cancer recurrence and between HLA-Cw2 and lymphatic involvement of thyroid carcinoma [17].…”

“…A significant association was reported between the lower incidence of the HLA-Cw4 allele and the appearance of multinodular goiter that suggest a protective effect for HLA-Cw4 allele against multinodular goiter [22]. Also in another study the absence of the HLA-Cw4 allele was associated with goiters presenting with an intrathoracic component and greater weight [23]. The HLA-Cw1 was associated with the presence of goiter-associated thyroid carcinoma [23].…”

HLA Class II Allele Groups Involved in Autoimmune Thyroid Diseases: Hashimoto’s Thyroiditis and Basedow–Graves Disease

“…Several studies indicate that the HLA-DRB1*04, *08, and *09 allele groups [48,50,55,66], and the HLA-DQB1*03, *04 and *06 allele groups [55,63,64,66], respectively, act as risk factors for HT. On the other hand, HLA-DRB1*03, *08 and *09 [38,48,54,[57][58][59][60][61]66], along with the HLA-DQB1*03, *05 and *06 allele groups [49,51,54,65,68,69,[71][72][73], were found to be risk factors for BGD. In contrast, the HLA-DRB1*03 and *10 allele groups [56], along with the HLA-DQB1*03, *05 and *06 allele groups [51,55,64,67,77], were identified as protective factors against HT, with a similar influence in regard to BGD being observed for the HLA-DRB1*01 and *12 [50][51][52][53][54]70,73], and HLA-DQB1*05 and *06 allele groups [51][52][53][54]73,76,…”

Identification of the novel HLA‐C*04:440 allele using next‐generation sequencing

“…In addition, HLA-C alleles have been reported to have disease association in multinodular goiters, B-chronic lymphocytic leukemia, and psoriasis. 4,5 The novel HLA-C*04:440 allele was identified during the evaluation of HLA genotyping of a hematopoietic stem cell donor with informed consent. The extracted nucleic acid of the donor was prepared to make the libraries for next-generation sequencing using the reagents NGSgo-AmpX, -LibrX, and -IndX (GenDx, Utrecht, The Netherlands) according to the manufacturer's instructions.…”