Associations of Helicobacter pylori infection and peptic disease with diabetic mellitus: Results from a large population-based study

Abstract

BackgroundEvidence is conflicting regarding the association between Helicobacter pylori infection and diabetes mellitus. The study objective was to examine associations of H. pylori infection, gastric ulcers and duodenal ulcers, with diabetes mellitus.MethodsThis cross-sectional study was undertaken using coded data from the computerized database of Maccabi Health Services in Israel, on 147,936 individuals aged 25–95 years who underwent the urea breath test during 2002–2012. Multiple logistic regression models were conducted, while adjusting for known risk factors for diabetes mellitus.ResultsA H. pylori positive test was recorded for 76,992 (52.0%) individuals and diabetes for 12,207 (8.3%). The prevalence of diabetes was similar in individuals with and without H. pylori infection, but this association was modified (P for heterogeneity 0.049) by body mass index (BMI): adjusted odds ratio (aOR) 1.16 (95% confidence intervals (CI) 1.04–1.29) in persons with BMI<25 kg/m2 versus aOR 1.03 (95% CI 0.98–1.08) in persons with BMI≥25 kg/m2. Diabetes mellitus prevalence was higher in persons with gastric (aOR 1.20 (95% CI 1.06–1.34)) and duodenal ulcers (aOR 1.20 (95% CI 1.12–1.28)) compared to persons without these diagnoses.ConclusionsIn this large population-based study, we demonstrated significant positive associations, albeit of small magnitude, of H. pylori infection and peptic disease with diabetes. The long-term gastric inflammation and associated-damage to the gastric mucosa might play a role in such associations.

Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study

“…MHS is ranked as the second largest HMO in Israel, insuring about two million people, i.e., about one-quarter of the population. The study cohort has been described in detail 32 . Briefly, we accessed deidentified information of persons aged 25 years or older who underwent UBT during 2002–2012.…”

Helicobacter pylori infection and prevalence of stroke

“…28,29 The study included data of adults aged 25-95 years who performed the urea breath test (UBT) between 2002 and 2012. MHS HMO has two million insured persons, corresponding to ~25% of the population in Israel.…”

“…Details on the study cohort were described elsewhere. 28,29 The study included data of adults aged 25-95 years who performed the urea breath test (UBT) between 2002 and 2012.…”

An Overview of Helicobacter Pylori Infection and Its Mystery

“…The burden ensuing from H. pylori infection is enormous. Haj et al (2017) revealed that H. pylori causes persistent gastritis and small intestine ulcers, and in uncommon events gastric malignant growth and lymphoma, that typically develop throughout adulthood. Many studies have addressed the link between H. pylori infection and diabetes mellitus (DM), a medical condition ensuing from either duct gland not producing enough hypoglycemic agent, or cells of the body improperly responding to the insulin created as reported by Awuchi et al (2020).…”

“…Gastric irritation and damage to the gastric tissue layer can be at the bottom of a relationship between H. pylori disease and diabetes mellitus. However, the role of peptic ulcerations, that develop following persistent internal organ inflammation in DM, has seldom been assessed (Haj et al, 2017).…”