Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case–control study

Abstract

BackgroundNoise-induced hearing loss (NIHL) is a complex disease caused by environmental and genetic risk factors. This study explored the relationship between the genetic variations in the CASP gene and the risk of developing NIHL among Chinese workers exposed to occupational noise.MethodsA case–control study of 272 NIHL workers and 272 normal-hearing workers matched for age, sex and years of noise exposure was conducted. Fifteen single-nucleotide polymorphisms (SNP) in the CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, CASP9, CASP10 and CASP14 genes were genotyped using the polymerase chain reaction–ligase detection reaction method. Using conditional logistic regression models, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of genetic variations associated with NIHL risk were calculated.ResultsTwo SNPs in the CASP3 gene were associated with NIHL risk. For rs1049216, TT genotype was associated with a decreased risk of NIHL (OR = 0.246, 95% CI = 0.069–0.886) when compared with the CC genotype. For rs6948, the AC and CC genotype were associated with a decreased NIHL risk (OR = 0.568, 95% CI = 0.352–0.916) compared with AA genotype. There were joint effects of working time and CASP3 polymorphisms on NIHL risk (P < 0.05).ConclusionsGenetic variations in the CASP3 gene and the joint effects of working time and CASP3 polymorphisms may modify the risk of developing NIHL.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0280-y) contains supplementary material, which is available to authorized users.

Associations of noise kurtosis, genetic variations in NOX3 and lifestyle factors with noise-induced hearing loss

“…The binaural high-frequency hearing threshold which was greater than 25 dB was noise-induced hearing loss [21], otherwise is non-binary high-frequency hearing loss.…”

Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

“…e mutation of the binding site of the target gene of miRNAs will affect the biosynthesis or biological function of miRNAs, which will lead to the disorder of cellular function and eventually result in the occurrence of diseases. SNPs can have a profound impact on miRNA function, including transcription, maturation, and target specificity [32], and it can also affect the occurrence of NIHL [33]. Recent studies have shown that SNPrs11077 in XPO5 gene is related to the risk of esophageal cancer, colorectal cancer, and renal cancer [34][35][36].…”

“…e A>C polymorphism of XPO5 gene will reduce the risk of CAD (coronary artery disease), which may be due to the influence on the expression of mature miRNAs and their gene function [37]. At the same time, functional SNPs in miRNA biogenetic pathway genes have been confirmed to be related to the increased risk of NIHL [33,38]. Based on all the above studies, we analyzed the relationship between the functional sites of XPO5 of miRNA processing gene and NIHL, and its effect on miRNA expression.…”

“…Importantly, miRNA-4763 has recently been shown to contribute specifically to multidrug resistance in human cancer cells [32]. Wang et al [33] reported that downregulation of miRNA-4763-3p expression increased the susceptibility to gastric cancer by targeting MDR. It was also predicted that the potential regulatory pathway of XPO5rs11077, and the binding ability of miRNA-4763-5p/miRNA-5002-3p would be affected when the T wild-type allele mutated into the G allele [34].…”

Association of STAT3 Gene Polymorphism With Noise-induced Hearing Loss(NIHL) in the Chinese Population

“…The most common sensory organ defect in the world is hearing loss [24]. Hearing can be impaired directly by high-intensity and long-term noise exposure, eventually leading to NIHL [25].…”