Associations of genetic polymorphisms of SAA1 with cerebral infarction

Zhang, Lijun; Yuan, Bin; Li, Hehua; Tao, Sheng-Bo; Yan, Haiying; Chang, Li; Zhao, Jianhua

doi:10.1186/1476-511x-12-130

Cited by 7 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, Xie et al reported that rs12218 polymorphism in SAA1 gene was associated with IMT [ 17 ], HDL-C [ 18 , 19 ], Ankle-brachial index (ABI) [ 20 ], and plasma uric acid levels [ 18 ] which was related to cardiovascular disease in adults. And Zhang et al reported SAA1 gene polymorphism was associated with cerebral infarction [ 21 ]. Xu et al also reported SAA1 gene polymorphism was associated with lipid levels [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

SAA1 gene variants and childhood obesity in China

et al. 2013

View full text Add to dashboard Cite

BackgroundObesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. SAA is a member of apolipoprotein and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to assess SAA1 allelic variants with obesity in young school-age children.MethodsA total of 520 consecutive children ages 5–15 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score ≥1.65; n = 253) and non-obese (NOB; n = 267). Four SNPs of the human SAA1 gene (rs12218, rs4638289, rs7131332 and rs11603089) were genotyped by use of polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) method.ResultsCompared to NOB, circulating SAA levels were increased in OB, as were LDL-C, TG and TC concentration. Obese children showed increased frequency of rs12218 and rs4638289 polymorphism compared to control children. There were no differences between OB and NOB for the other 2 polymorphisms. Only the rs4638289 polymorphism showed significant contributions to higher SAA plasma levels.ConclusionsSAA1 genetic polymorphism was associated with obesity in Chinese children.

show abstract

Section: Resultsmentioning

confidence: 99%

SAA1 gene variants and childhood obesity in China

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The CC genotype of rs12218 was more frequent among patients suffering from coronary artery disease (Xie et al, 2015). This genotype was also more frequent in patients suffering from cerebral infarction (Zhang et al, 2013a). In comparison, the TT genotype of rs12218 is associated with an increased serum uric acid level (Xie et al, 2012) and with susceptibility to osteoporosis (Feng et al, 2013).…”

Section: Human Saa1 Polymorphism and Disease Dispositionmentioning

confidence: 97%

Serum amyloid A1: Structure, function and gene polymorphism

Sun

2016

Gene

158

134

View full text Add to dashboard Cite

Inducible expression of serum amyloid A (SAA) is a hallmark of the acute-phase response, which is a conserved reaction of vertebrates to environmental challenges such as tissue injury, infection and surgery. Human SAA1 is encoded by one of the four SAA genes and is the best-characterized SAA protein. Initially known as a major precursor of amyloid A (AA), SAA1 has been found to play an important role in lipid metabolism and contributes to bacterial clearance, the regulation of inflammation and tumor pathogenesis. SAA1 has five polymorphic coding alleles (SAA1.1 – SAA1.5) that encode distinct proteins with minor amino acid substitutions. Single nucleotide polymorphism (SNP) has been identified in both the coding and non-coding regions of human SAA1. Despite high levels of sequence homology among these variants, SAA1 polymorphisms have been reported as risk factors of cardiovascular diseases and several types of cancer. A recently solved crystal structure of SAA1.1 reveals a hexameric bundle with each of the SAA1 subunits assuming a 4-helix structure stabilized by the C-terminal tail. Analysis of the native SAA1.1 structure has led to the identification of a competing site for high-density lipoprotein (HDL) and heparin, thus providing the structural basis for a role of heparin and heparan sulfate in the conversion of SAA1 to AA. In this brief review, we compares human SAA1 with other forms of human and mouse SAAs, and discuss how structural and genetic studies of SAA1 have advanced our understanding of the physiological functions of the SAA proteins.

show abstract

“…Numerous studies have shown that various environmental variables and genetic variations contribute to the etiology of CI. 12 Previously published studies showed that ApoE polymorphisms have been associated with CI, although with varying degrees of success. 13 , 14 In the present case, the ε3/ε3 genotype and ε3 allele were significantly lower in patients than the controls, indicating its potential protective role.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population

Wang¹,

Yang²,

Zhang³

et al. 2023

PGPM

View full text Add to dashboard Cite

Background The apolipoprotein E (ApoE) genetic variation may contribute to the development of Cerebral Infarction (CI). Serum lipid levels are known risk factors for CI, but the effect of the ApoE gene polymorphism on lipid metabolism remains unclear. This retrospective cohort study was designed to determine the role of ApoE genotypes in CI risk and the relationships between ApoE gene polymorphism and serum lipid levels among the population of northwest China. Patients and Methods 517 CI patients and 517 non-CI controls were enrolled in the study. Polymerase chain reaction and hybridization were utilized to determine the ApoE gene polymorphisms. Results The ε3/ε4 genotype and ε4 allele frequency were significantly higher in CI patients than in controls. When stratified by age and sex, statistically significant differences in the distribution and frequency of the ε3/ε4 genotype and ε4 allele were found between patients and controls. Compared to ε2 carriers, ε4 carriers had significantly lower ApoE levels and higher low-density lipoprotein cholesterol (LDL-C), ApoB and ApoB/ApoA-I levels in both two groups. Additionally, control participants with ε4 carriers had significantly higher levels of lipoprotein and total cholesterol (TC) levels than ε2 carriers, while CI patients with ε4 carriers had a significantly lower level of ApoA-I. After adjusting for other established risk factors, drinking, hypertension, lipoprotein, triglycerides (TG) and ε4 allele were significant independent risk factors for CI, which was shown to be associated with a nearly two-fold CI risk. Conclusion This study demonstrated that ε4 allele is independent risk factors for CI among patients in Northwest China. ApoE polymorphism was associated with CI, which was partly mediated through blood lipids and may also be mediated through non-lipid pathways. These data might be of great clinical significance in individualized preventive and therapeutic strategies.

show abstract

Associations of genetic polymorphisms of SAA1 with cerebral infarction

Cited by 7 publications

References 14 publications

SAA1 gene variants and childhood obesity in China

SAA1 gene variants and childhood obesity in China

Serum amyloid A1: Structure, function and gene polymorphism

Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population

Contact Info

Product

Resources

About