Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women

Bragg, Fiona; Tang, Kun; Guo, Yu; Iona, Andri; Du, Huaidong; Holmes, Michael V; Zheng, Bin; Kartsonaki, Christiana; Chen, Yiping; Yang, Ling; Sun, Qiang; Dong, Caixia; Chen, Junshi; Collins, Rory; Pető, Richárd; Li, Liming; Chen, Zhengming

doi:10.2337/dc17-1852

Cited by 81 publications

(74 citation statements)

References 36 publications

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“…In contrast to the J‐shaped relationship of BMI with adverse outcomes, abdominal obesity measured by the waist circumference was found to linearly associate with cardiovascular disease mortality in Europeans . This relatively newer measure of adiposity, which reflects central obesity, was found to associate more strongly with diabetes risk, especially in “thin” Chinese, Koreans, and other Asians. This may explain their propensity to “obesity” and its adverse outcomes despite less elevated BMI.…”

Section: Introductionmentioning

confidence: 83%

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Kim

Basharat

Ramakrishnan

et al. 2018

Diabetes Metabolism Res

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Over-nutrition and its late consequences are a dominant theme in medicine today. In addition to the health hazards brought on by over-nutrition, the medical community has recently accumulated a roster of health benefits with obesity, grouped under "obesity paradox." Throughout the world and throughout history until the 20 century, under-nutrition was a dominant evolutionary force. Under-nutrition brings with it a mix of benefits and detriments that are opposite to and continuous with those of over-nutrition. This continuum yields J-shaped or U-shaped curves relating body mass index to mortality. The overweight have an elevated risk of dying in middle age of degenerative diseases while the underweight are at increased risk of premature death from infectious conditions. Micronutrient deficiencies, major concerns of nutritional science in the 20 century, are being neglected. This "hidden hunger" is now surprisingly prevalent in all weight groups, even among the overweight. Because micronutrient replacement is safe, inexpensive, and predictably effective, it is now an exceptionally attractive target for therapy across the spectrum of weight and age. Nutrition-related conditions worthy of special attention from caregivers include excess vitamin A, excess vitamin D, and deficiency of magnesium.

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Section: Introductionmentioning

confidence: 83%

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Kim

Basharat

Ramakrishnan

et al. 2018

Diabetes Metabolism Res

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“…As early as 2009, they suggested that the best range to predict hypertension were 87 cm in men and 80 cm in women, and increasing WC over time could be the cause of the difference. The worldwide upward trend in obesity has been dramatic; from 2013 to 2018, the mean WC increased from 82 cm to 86.3 cm for men and from 79.1 cm to 83.4 cm for older women [32]. However,lower appropriate level were suggested by previous studies [33,34], and ethnic and racial differences might explain the discrepancy between different studies.…”

Section: Discussionmentioning

confidence: 87%

Association of Body Mass Index and Waist Circumference with Hypertension in Older Adults

Zhang¹,

He²,

Zhao³

et al. 2020

Preprint

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Background: The relationship between obesity and prevalent hypertension in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with hypertension, and to assess the appropriate level of BMI and WC for hypertension. Methods: We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for hypertension. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for hypertension. Results: The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for hypertension were 1.084 (1.080-1.087) and 1.025 (1.024-1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with hypertension in both men and women (all P<0.001). The risk of hypertension increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of hypertension was significantly enhanced. Conclusion: These findings suggest increased hypertension prevalence in the elderly population with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of hypertension in older adults.

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“…Nowadays, more and more attention has been paid to sleep duration among the individuals with obesity [3]. Sleep deprivation among students is regarded to be related to increased risk of obesity, injuries, behavior problems, attention-de cit disorder, poor academic performance and psychological problems [4][5][6]. In adulthood, sleep deprivation is a risk factor of cardiovascular diseases [7].…”

Section: Introductionmentioning

confidence: 99%

Association between Sleep Duration and Overweight/Obesity risk among middle-school students: a cross-sectional study in Fuzhou, China

Wei

Zheng

et al. 2020

Preprint

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Abstract Background: This study was designed to investigate the prevalence of sleep deprivation and explore the association between sleep duration and overweight or obesity in adolescents from middle school in Fuzhou, China.Methods: Questionaires focusing on sleep duration and overweight or obesity related factors were collected. A generalized linear hybrid model was used to evaluate the effects of sleep duration on overweight or obesity in school students.Results: The overall rates of overweight and obesity were 12.1% and 7.1%, respectively. The prevalence of sleep deprivation among students was 82.8%. The majority of high school students (92.5%) suffered from insufficient sleep. Compared with male children with a sleep duration of over 8 hrs a day, the odds ratios (95% CI) of overweight/obesity for those with a sleep duration of less than 6 h or 6 - 8 h, were 1.63 (1.25-2.13) and 1.06 (0.88-1.27). After adjusting social and demographic status, mental health and lifestyle factors, the odds ratios of female children were 1.38(0.99-1.93) and 1.04 (0.79-1.35), respectively.Conclusions: A large number of adolescents suffered from insufficient sleep. Sleep duration was negatively correlated with overweight or obesity among male children.

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Associations of General and Central Adiposity With Incident Diabetes in Chinese Men and Women

Abstract: Among relatively lean Chinese adults, higher adiposity-general and central-was strongly positively associated with the risk of incident diabetes. The predicted continuing increase in adiposity in China foreshadows escalating rates of diabetes.

Cited by 81 publications

References 36 publications

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Association of Body Mass Index and Waist Circumference with Hypertension in Older Adults

Association between Sleep Duration and Overweight/Obesity risk among middle-school students: a cross-sectional study in Fuzhou, China

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