Associations of gene polymorphisms in interferon‐alpha signature‐related genes with autoimmune thyroid diseases

Lin, Jiunn Diann; Yang, Shun Fa; Wang, Yuan Hung; Fang, Wen; Tang, Kuo‐Tung; Cheng, Chao‐Wen

doi:10.1111/cen.14090

Cited by 6 publications

(1 citation statement)

References 44 publications

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“…The hotspot SNPs of IRF-3 gene were rs2304204 and rs2304206 loci. Most studies concluded that rs2304204 does not affect IRF-3 protein expression and is not significantly associated with the disease [27][28][29]. The present study showed that the genotype and allele frequency distribution of the rs2304204 locus were not associated with CHC and plasma levels of IRF-3 or IFN-β.…”

Section: Comparison Of Plasma Irf-3 and Ifn-β Levels Between Different Genotypessupporting

confidence: 38%

Association of Interferon Regulatory Factor-3 Gene Polymorphisms With Infection and Antiviral Efficacy of Chronic Hepatitis C Virus

Yang

Wang

Liu

et al. 2021

Preprint

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Background Hepatitis C virus (HCV) is a major public health concern in developing countries. Pathogenesis of hepatitis C infection is poorly understood. Previously, we found higher Interferon Regulatory Factor-3 (IRF-3) expression in HCV-infected patients. However, the effect of IRF-3 polymorphism on the incidence of HCV infection and antiviral efficacy has not been sufficiently evaluated.Methods We retrospectively enrolled 178 patients with chronic hepatitis C (CHC) and 82 matched healthy controls between 2016 and 2019 at the Second Hospital of Wenzhou Medical University, China. All patients received a standard dose of polyethylene glycol interferon + ribavirin (PR regimen), and were divided into the response, non-response, sustained virological response (SVR), and non-sustained virological response (NSVR) groups based on their HCV RNA levels. Gene polymorphisms were detected by DNA sequencing, and the plasma IRF-3 and IFN-β levels were measured by ELISA to assess the impact of IRF-3 gene variations and contents on the risk of HCV infection and antiviral efficacy.Results Plasma contents of IRF-3 and IFN-β were significantly different between the CHC and control groups, the response and non-response groups, and the SVR and non-SVR groups (p<0.05). rs2304206 C>T but not rs2304204A>G was associated with increased risk for CHC (OR= 2.35 (95% CI: 1.30 to 4.24), p = 0.004), and reduced antiviral efficacy between both response groups (OR= 1.86 (95% CI: 1.06 to 3.24), p = 0.028) and SVR groups (OR= 1.79 (95% CI:1.05 to 3.06), p = 0.030). Haplotype GT type suffered negative consequence between the CHC and control groups, the responder and non-responder groups, and the SVR and non-SVR groups (p=0.004, 0.028, 0.030). The content of IFR-3 in CT genotype of rs2304206 was higher than that in CC genotype.Conclusion The polymorphism of IFR-3 affects the plasma levels of IFR-3 and associated with HCV infection and interferon antiviral efficacy, where the T allele of rs2304206 may be a susceptibility factor for CHC and adversely impact interferon antiviral response.

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Section: Comparison Of Plasma Irf-3 and Ifn-β Levels Between Different Genotypessupporting

confidence: 38%

Association of Interferon Regulatory Factor-3 Gene Polymorphisms With Infection and Antiviral Efficacy of Chronic Hepatitis C Virus

Yang

Wang

Liu

et al. 2021

Preprint

View full text Add to dashboard Cite

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Gene polymorphisms of molecules of the cGAS-STING signalling pathway are associated with AML in Chinese patients

Ma,

Wang,

Feng

et al. 2024

Holist Integ Oncol

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Purpose The aim of this study was to explore the relationships between single-nucleotide polymorphisms (SNPs) of crucial molecules in the cGAS-STING signalling pathway and the susceptibility to, induction chemotherapy response of, and prognosis of acute myeloid leukaemia (AML) in Chinese patients. Methods Thirteen SNPs of crucial molecules in the cGAS-STING signalling pathway were genotyped in 262 AML patients using the Sequenom MassARRAY system. The associations of SNPs with susceptibility, and induction chemotherapy response were analysed using the chi-square test or Fisher’s exact test and univariate binary logistic regression, the connection of SNPs with prognosis of AML was analysed using the log-rank test, and Kaplan–Meier curves were applied for survival estimation. Results In our study, gene polymorphisms of cGAS-STING signalling pathway molecules could be vitally associated with AML. In the recessive model, the cGAS rs311678 gene polymorphism could be closely related to AML susceptibility (CC vs. TT + TC, odds ratio (OR) = 0.480, 95% confidence interval (CI) = 0.260–0.889, p = 0.020). Moreover, IKKA rs3808917 might be associated with the WBC count, cGAS rs311678 could be associated with the bone marrow (BM) blast percentage, and NF-κB rs1056890 under codominant and recessive models could be connected with the HGB level. Patients who were STING rs7380272 TT/CT carriers was likely to have higher insensitivity to induction chemotherapy than CC carriers (TT + CT vs. CC, OR = 2.917, 95% CI = 1.073–7.929, p = 0.036). Survival analysis indicated that the IKKB rs3747811 TT genotype might be associated with decreased overall survival (OS) (p < 0.05). Conclusions SNPs of molecules in the cGAS-STING signalling pathway could be significantly associated with AML. The cGAS rs311678 gene polymorphism could be associated with AML susceptibility, the STING rs7380272 variant might be related to induction chemotherapy response, and IKKB rs3747811 tended to be associated with AML overall survival. Moreover, IKKA rs3808917 could be associated with the WBC count, cGAS rs311678 could be associated with the BM blast percentage, and NF-κB rs1056890 might be related to the HGB level.

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Serum interferon levels associated with the disease activity in women with overt Graves' disease

et al. 2021

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Associations of gene polymorphisms in interferon‐alpha signature‐related genes with autoimmune thyroid diseases

Cited by 6 publications

References 44 publications

Association of Interferon Regulatory Factor-3 Gene Polymorphisms With Infection and Antiviral Efficacy of Chronic Hepatitis C Virus

Association of Interferon Regulatory Factor-3 Gene Polymorphisms With Infection and Antiviral Efficacy of Chronic Hepatitis C Virus

Gene polymorphisms of molecules of the cGAS-STING signalling pathway are associated with AML in Chinese patients

Serum interferon levels associated with the disease activity in women with overt Graves' disease

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