Associations of Fibroblast Growth Factor 23 and Fetuin-A with Coronary Plaque Burden and Plaque Composition in Young Adults

Akın, Fatih; Çelik, Ömer; Ayça, Burak; Altun, İbrahim; Diker, Vesile Ornek; Byk, Ismail; Siriopol, Dimitrie; Covic, Adrian; Kanbay, Mehmet

doi:10.1097/jim.0000000000000153

Cited by 5 publications

(1 citation statement)

References 36 publications

(28 reference statements)

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“…FGF-23 is a bone-derived hormone whose primary role is to regulate vitamin D metabolism and renal phosphate homeostasis; meanwhile, it has been reported that FGF-23 regulates the development of cardiovascular disease by motivating nitric oxide (NO) production, endothelial nitric oxide synthase (eNOS) expression, and cell proliferation in human aortic endothelial cells ( 9 , 18 ). Moreover, a study claims that FGF-23 exhibits a higher expression in CAD patients than in non-CAD patients ( 19 ). Nevertheless, no relevant studies explore the variation of FGF-23 levels in ULMCAD patients before and after CABG.…”

Section: Discussionmentioning

confidence: 99%

Perioperative variation in serum FGF-23 level and its correlation with MACCE risk in unprotected left main coronary artery disease patients receiving coronary artery bypassing grafting

Wang

2022

Front. Surg.

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ObjectiveFibroblast growth factor-23 (FGF-23) mediates vascular endothelial injury, inflammatory infiltration, and atherosclerosis, which could reflect major adverse cardiac and cerebrovascular event (MACCE) risk in several cardiovascular diseases. This study aims to further investigate the perioperative change of FGF-23, as well as its association with clinical characteristics and MACCE risk in unprotected left main coronary artery disease (ULMCAD) patients receiving coronary artery bypass grafting (CABG).MethodsA total of 226 ULMCAD patients who underwent CABG were enrolled. Serum samples of the patients were collected on the day before CABG, the third day (D3) after CABG, and at discharge; then, the FGF-23 level was determined by enzyme-linked immunosorbent assay. The MACCE rate was recorded during a median follow-up of 25.5 (range: 2.0–46.0) months.ResultsThe median, interquartile range (IQR), and range of FGF-23 level in ULMCAD patients receiving CABG were 717.0, 582.5–869.8, and 407.0–1765.0 pg/ml, respectively. FGF-23 level was increased in patients with both previous heart failure (P = 0.046) and chronic renal failure (P = 0.009) compared to those without. FGF-23 level increased from before surgery [median (IQR): 712.5 (574.5–879.8) pg/ml] to D3 [median (IQR): 844.0 (666.0–1072.5) pg/ml], then declined at discharge [median (IQR): 764.5 (569.3–986.8) pg/ml] (P < 0.001). Meanwhile, the preoperative FGF-23 level (P = 0.028), but not the FGF-23 level at discharge (P = 0.067) was positively correlated with the cumulative MACCE rate. Multivariable Cox's analyses found that preoperative FGF-23 level could independently predict cumulative MACCE rate [P = 0.015, hazards ratio (HR) = 2.940].ConclusionPreoperative FGF-23 level predicts higher MACCE risk in ULMCAD patients undergoing CABG surgery.

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Section: Discussionmentioning

confidence: 99%

Perioperative variation in serum FGF-23 level and its correlation with MACCE risk in unprotected left main coronary artery disease patients receiving coronary artery bypassing grafting

Wang

2022

Front. Surg.

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The dysregulation of plasma miR-497/FGF23 axis, and its association with clinical characteristics and major adverse cardiovascular event in female premature acute coronary syndrome patients

Cai

et al. 2023

Ir J Med Sci

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Bone loss and vascular calcification: A bi-directional interplay?

Vassalle

Mazzone

2016

Vascular Pharmacology

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Associations of Fibroblast Growth Factor 23 and Fetuin-A with Coronary Plaque Burden and Plaque Composition in Young Adults

Abstract: The presence of subclinical CAD is independently associated with FGF-23 and fetuin-A and could be used as novel risk markers of cardiovascular disease in the asymptomatic young adult population.

Cited by 5 publications

References 36 publications

Perioperative variation in serum FGF-23 level and its correlation with MACCE risk in unprotected left main coronary artery disease patients receiving coronary artery bypassing grafting

Perioperative variation in serum FGF-23 level and its correlation with MACCE risk in unprotected left main coronary artery disease patients receiving coronary artery bypassing grafting

The dysregulation of plasma miR-497/FGF23 axis, and its association with clinical characteristics and major adverse cardiovascular event in female premature acute coronary syndrome patients

Bone loss and vascular calcification: A bi-directional interplay?

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