Associations of exposure to multiple metals with blood pressure and hypertension: A cross-sectional study in Chinese preschool children

Li, Yanli; Yu, Lili; Zhu, Meiqin; Lin, Wei; Liu, Yang; Li, Mingzhu; Zhang, Yao; Ji, Hongxian; Wang, Jing

doi:10.1016/j.chemosphere.2022.135985

Cited by 10 publications

(8 citation statements)

References 51 publications

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“…Compared to the lowest quartile of urinary Cr levels, children in the highest quartile had a 0.48-fold (95% CI: 0.25-0.88) decrease in the odds of hypertension. This association was more pronounced among 2-4-year-old children [56].…”

Section: Cr Exposure and Health Outcomes In Childhoodmentioning

confidence: 80%

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Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence

Sazakli

2024

IJERPH

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The toxicity and carcinogenicity of hexavalent chromium via the inhalation route is well established. However, a scientific debate has arisen about the potential effects of oral exposure to chromium on human health. Epidemiological studies evaluating the connection between ingested chromium and adverse health effects on the general population are limited. In recent years, a wealth of biomonitoring studies has emerged evaluating the associations between chromium levels in body fluids and tissues and health outcomes. This systematic review brings together epidemiological and biomonitoring evidence published over the past decade on the health effects of the general population related to oral exposure to chromium. In total, 65 studies were reviewed. There appears to be an inverse association between prenatal chromium exposure and normal fetal development. In adults, parameters of oxidative stress and biochemical alterations increase in response to chromium exposure, while effects on normal renal function are conflicting. Risks of urothelial carcinomas cannot be overlooked. However, findings regarding internal chromium concentrations and abnormalities in various tissues and systems are, in most cases, controversial. Environmental monitoring together with large cohort studies and biomonitoring with multiple biomarkers could fill the scientific gap.

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Section: Cr Exposure and Health Outcomes In Childhoodmentioning

confidence: 80%

“…In a cross-sectional study [56], a protective role of Cr against high blood pressure was observed. Compared to the lowest quartile of urinary Cr levels, children in the highest quartile had a 0.48-fold (95% CI: 0.25-0.88) decrease in the odds of hypertension.…”

Section: Cr Exposure and Health Outcomes In Childhoodmentioning

confidence: 95%

Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence

Sazakli

2024

IJERPH

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“…Previous studies have found that the levels of these different metals typically exhibit medium-strength correlation (r = 0.31–0.81 and −0.15–0.74, respectively) [ 53 , 55 ]; these results are similar to the results of the current study. Previous studies have also shown that combined exposure to multiple metals is also positively associated with increased risk of multiple human diseases [ 56 , 57 ]. In view of the extensive exposure of the population to various metals in the course of their daily life, further studies are needed to clarify the human health impact of such metals.…”

Section: Resultsmentioning

confidence: 99%

Urinary Levels of 14 Metal Elements in General Population: A Region-Based Exploratory Study in China

Zhang,

Guo,

Hua

et al. 2023

Toxics

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Metal pollution may lead to a variety of diseases; for this reason, it has become a matter of public concern worldwide. However, it is necessary to use biomonitoring approaches to assess the risks posed to human health by metals. In this study, the concentrations of 14 metal elements in 181 urine samples obtained from the general population of Gansu Province, China, were analyzed using inductively coupled plasma mass spectrometry. Eleven out of fourteen target elements had detection frequencies above 85%, namely, Cr, Ni, As, Se, Cd, Al, Fe, Cu and Rb. The concentrations of most metal elements in the urine of our subjects corresponded to the medium levels of subjects in other regional studies. Gender exerted a significant influence (p < 0.05) on the concentrations of Tl, Rb and Zn. The concentrations of Ni, As, Pb, Sr, Tl, Zn, Cu and Se showed significant differences among different age groups and the age-related concentration trends varied among these elements. There were significant differences in the urine concentrations of Zn and Sr between those subjects in the group who were frequently exposed to soil (exposed soil >20 min/day) and those in the group who were not, indicating that people in regular contact with soil may be more exposed to metals. This study provides useful information for evaluating the levels of metal exposure among general populations.

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“…The relationship between long-term chromium exposure and hypertension is contradictory. A study focused on preschool children proposed a negative association between chromium and barium exposure and both blood pressure and hypertension [11]. However, another study indicated that residing in regions with heightened chromium and arsenic exposure was correlated with an increased risk of hypertension [12].…”

Section: Introductionmentioning

confidence: 99%

The association between the urinary chromium and blood pressure: a population-based study

Liang,

Liu,

Yang

2024

BMC Cardiovasc Disord

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Background and Aim The impact of trace elements and heavy metals on human health has attracted widespread attention. However, the correlation between urinary chromium concentrations and blood pressure remains unclear and inadequately reported, and the aim of this study was to investigate the relationship between urinary chromium concentrations and blood pressure in adults in the United States (US). Methods We utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017–2018 for this study. Multivariate logistic regression and multivariate linear regression were used to explore the association of urinary chromium concentrations with hypertension and blood pressure. Additionally, we also performed subgroup analysis and restricted cubic splines (RCS). Results A total of 2958 participants were enrolled in this study. The overall mean systolic blood pressure and diastolic blood pressure were 123.98 ± 0.60, 72.66 ± 0.57 mmHg, respectively. The prevalence of hypertension was found in 41.31% of the whole participants. In the fully adjusted model, we did not observe a correlation between urinary chromium concentrations and the risk of hypertension and systolic blood pressure. However, we found a negative association between urinary chromium concentrations and diastolic blood pressure. In subgroup analysis, we observed a positive association between urinary chromium and the risk of hypertension among participants older than 60 years of age and those who were Non-Hispanic Black. The interaction term highlighted the influence of age and race on this positive association. We also found a negative association of urinary chromium with diastolic blood pressure in male, participants who were current smokers, overweight, and other races, as well as those without alcohol use and anti-hypertensive drug use. However, the interaction term only revealed the influence of alcohol consumption on the negative association. Conclusion Our study suggested that urinary chromium concentrations may show a negative association with diastolic blood pressure and this association was significantly dependent on alcohol consumption. Besides, a positive association between urinary chromium and the risk of hypertension was also found among participants older than 60 years of age and those who were Non-Hispanic Black.

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Associations of exposure to multiple metals with blood pressure and hypertension: A cross-sectional study in Chinese preschool children

Cited by 10 publications

References 51 publications

Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence

Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence

Urinary Levels of 14 Metal Elements in General Population: A Region-Based Exploratory Study in China

The association between the urinary chromium and blood pressure: a population-based study

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