Associations of exposure to heavy metal mixtures with kidney stone among U.S. adults: A cross-sectional study

Zhao, Hui; Fang, Lanlan; Chen, Yuting; Ma, Yubo; Xu, Shanshan; Jianping, Ni; Chen, Xuyang; Wang, Guosheng; Pan, Faming

doi:10.1007/s11356-023-29318-7

Cited by 5 publications

(3 citation statements)

References 72 publications

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“…Zhao et al have analyzed the associations of exposure to heavy metal mixtures with kidney stone. They got a positive association between the two ( 31 ), which was different from the result in our research. The reason for this contrast may be that their study included more toxic heavy metals like mercury, for example, while our study included potentially beneficial trace elements like iodine (which was also formalized in our study).…”

Section: Discussioncontrasting

confidence: 99%

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Association and interactions between mixed exposure to trace elements and the prevalence of kidney stones: a study of NHANES 2017–2018

Wang,

Zhang,

et al. 2023

Front. Public Health

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BackgroundThe association between exposure to trace elements mixture and the prevalence of kidney stones and the interactions between elements are unclear. The aim of this study was to explore the association between exposure to trace elements mixture and the prevalence of kidney stones and the interactions between the elements.MethodsA total of 1,244 participants (139 kidney stone formers and 1,105 non-stone former participants) in NHANES 2017–2018 were included. The exposure to trace elements was evaluated by measuring their concentration in urine samples. Three methods, Logistic regression, quantile-based g computation (qgcomp), and Bayesian kernel machine regression (BKMR), were used for analysis.ResultsAccording to the results from qgcomp and BKMR, a negative association was found between exposure to the 13 trace elements and the prevalence of kidney stones [OR = 0.50 (0.32, 0.78)]. Subgroup analysis revealed that Co, As, and iodine in the whole population, Co, As, and Ni in males, and Cs, iodine, and Sb in females, were most strongly associated with kidney stones. Kidney stone was found to be positively correlated with Co and negatively correlated with the other elements. Besides, there were significant interactions between Ni and Pb in the whole population, Co and iodine in males, and Pb and iodine in females.ConclusionThere was a negative association between exposure to the mixture of 13 trace elements and the prevalence of kidney stones.

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Section: Discussioncontrasting

confidence: 99%

“…In this study, Co was found to be strongly positively associated with kidney stone, which was similar to the previous study ( 31 ). However, analysis of the composition of trace elements in kidney stones revealed that the levels of Co in various kidney stones were very low, mostly below the detection limit ( 39 ).…”

Section: Discussionsupporting

confidence: 92%

Association and interactions between mixed exposure to trace elements and the prevalence of kidney stones: a study of NHANES 2017–2018

Wang,

Zhang,

et al. 2023

Front. Public Health

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“…Secondly, to confirm the stability of the BKMR outcomes, we employed a weighted quantile sum (WQS) regression model. WQS regression offers a reliable method for characterizing environmental mixtures, assessing the collective impact of combined exposures on specific outcomes (27). In our study, we established a WQS index by utilizing quartiles of the urinary chemical mixtures.…”

Section: Discussionmentioning

confidence: 99%

Associations of perchlorate, nitrate, and thiocyanate exposure with arthritis and inflammation indicators in young and middle-aged adults, NHANES 2005-2016

Zhao,

Chen,

et al. 2024

Front. Immunol.

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BackgroundPerchlorates, nitrates, and thiocyanates are prevalent environmental chemicals. Their potential association with arthritis remains unexplored. This study aimed to investigate the link between perchlorate, nitrate, and thiocyanate exposure and arthritis, as well as the potential role of inflammation in this context.MethodsUtilizing the National Health and Nutrition Examination Survey (NHANES) data spanning from 2005 to 2016, the study enrolled 6597 participants aged 20-59 (young and middle-aged), of which 1045 had arthritis. Employing multivariate logistic regression modeling, multiple linear regression models, restricted cubic spline analysis, Bayesian kernel machine regression (BKMR) modeling, and mediation analysis, we assessed these relationships.ResultsThere was a significant positive association between elevated urinary thiocyanate levels and arthritis risk [1.19 (1.11, 1.28)]. This association held true across subgroups of osteoarthritis (OA) [1.24 (1.10, 1.40)] and rheumatoid arthritis (RA) [1.33 (1.15, 1.55)]. Thiocyanate levels displayed a dose-dependent relationship with arthritis risk, showing a linear trend (nonlinear P > 0.05). Conversely, perchlorate and nitrate did not exhibit associations with arthritis risk. BKMR outcomes highlighted a positive correlation between a mixture of perchlorate, nitrate, and thiocyanate and arthritis risk, with thiocyanate being the predominant predictors. Moreover, BKMR and generalized linear model analyses unveiled no significant synergistic effect of urinary perchlorate, nitrate, and thiocyanate on arthritis risk. Furthermore, thiocyanate exposure has been linked to elevated levels of inflammatory indicators (white blood cell, neutrophils, lymphocytes, and systemic immune-inflammatory index (SII)).ConclusionHeightened thiocyanate exposure may be linked to elevated arthritis risk, either single or in combined effects. Additionally, thiocyanate exposure is associated with heightened inflammation levels.

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Complex interplay of heavy metals and renal injury: New perspectives from longitudinal epidemiological evidence

Yin,

Zhao,

Zhao

et al. 2024

Ecotoxicology and Environmental Safety

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Associations of exposure to heavy metal mixtures with kidney stone among U.S. adults: A cross-sectional study

Cited by 5 publications

References 72 publications

Association and interactions between mixed exposure to trace elements and the prevalence of kidney stones: a study of NHANES 2017–2018

Association and interactions between mixed exposure to trace elements and the prevalence of kidney stones: a study of NHANES 2017–2018

Associations of perchlorate, nitrate, and thiocyanate exposure with arthritis and inflammation indicators in young and middle-aged adults, NHANES 2005-2016

Complex interplay of heavy metals and renal injury: New perspectives from longitudinal epidemiological evidence

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