Associations of event-related brain potentials and Alzheimer’s disease severity: A longitudinal study

Fruehwirt, Wolfgang; Dorffner, Georg; Roberts, Stephen; Gerstgrasser, Matthias; Grossegger, Dieter; Schmidt, Reinhold; Dal‐Bianco, Peter; Ransmayr, Gerhard; Garn, Heinrich; Waser, Markus; Benke, Thomas

doi:10.1016/j.pnpbp.2018.12.013

Cited by 29 publications

(19 citation statements)

References 38 publications

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“…In addition, studies in PD patients have shown a reduced P300 amplitude (200)(201)(202)(203)(204)(205)(206) or an increase in P300 latency (207,208), whereas in AD patients an increase in P300 latency was found (209)(210)(211)(212)(213). If the hypothesis given above is correct and an optimal rate of phasic LC activity is contingent upon a moderate level of tonic activity (1), then a reduction in P300 amplitude and/or FIGURE 1 | Relation between tonic and phasic LC discharge (blue curve) and proposed effects of t-VNS treatment.…”

Section: Persistent High Tonic Discharge Of Lc Neurons and Potential Implications For Neurodegenerative Diseasesmentioning

confidence: 99%

Impaired Phasic Discharge of Locus Coeruleus Neurons Based on Persistent High Tonic Discharge—A New Hypothesis With Potential Implications for Neurodegenerative Diseases

Janitzky

2020

Front. Neurol.

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The locus coeruleus (LC) is a small brainstem nucleus with widely distributed noradrenergic projections to the whole brain, and loss of LC neurons is a prominent feature of age-related neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). This article discusses the hypothesis that in early stages of neurodegenerative diseases, the discharge mode of LC neurons could be changed to a persistent high tonic discharge, which in turn might impair phasic discharge. Since phasic discharge of LC neurons is required for the release of high amounts of norepinephrine (NE) in the brain to promote anti-inflammatory and neuroprotective effects, persistent high tonic discharge of LC neurons could be a key factor in the progression of neurodegenerative diseases. Transcutaneous vagal stimulation (t-VNS), a non-invasive technique that potentially increases phasic discharge of LC neurons, could therefore provide a non-pharmacological treatment approach in specific disease stages. This article focuses on LC vulnerability in neurodegenerative diseases, discusses the hypothesis that a persistent high tonic discharge of LC neurons might affect neurodegenerative processes, and finally reflects on t-VNS as a potentially useful clinical tool in specific stages of AD and PD.

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Section: Persistent High Tonic Discharge Of Lc Neurons and Potential Implications For Neurodegenerative Diseasesmentioning

confidence: 99%

Impaired Phasic Discharge of Locus Coeruleus Neurons Based on Persistent High Tonic Discharge—A New Hypothesis With Potential Implications for Neurodegenerative Diseases

Janitzky

2020

Front. Neurol.

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“…Existen diversos trabajos que recurren al análisis de P300, ya que esta onda tiene un alto porcentaje de reconocimiento (Li et al, 2020) y se puede utilizar en aplicaciones como diferenciación de la edad, medición de alcoholismo (Gamboa & Cruz, 2008;Hamidovic & Wang, 2019), comunicación y control enfocado a personas con Alzheimer (Dal-Bianco et al, 2018;Jervis et al, 2020), esclerosis lateral amiotrófica (McCane et al, 2015), epilepsia (Akramova, 2017;Zhong et al, 2019), parálisis cerebral (Kim & Lee, 2016), etc. Los diversos sistemas de control y comunicación que utilizan la onda P300 son muy variados, por ejemplo, Akman et al proponen A-BCI (AKMAN AYDIN et al, 2017), un algoritmo para determinar las intenciones de un sujeto para controlar un sistema de internet por medio de 16 electrodos activos que tuvo un 93.71% de desempeño promedio.…”

Section: Introductionunclassified

Procesamiento embebido de p300 basado en red neuronal convolucional para interfaz cerebro-computadora ubicua

Macías-Macías¹,

Quintana²,

Aguirre

et al. 2021

recibe

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Se propone un método de bajo costo computacional para detectar el potencial evocado P300 en aplicaciones ubicuas de comunicación y control, el cual se denomina Procesamiento Embebido P300 (EP-300). La entrada de EP-300 es una señal electroencefalografía (EEG) de un canal y la arquitectura de este método se basa en los algoritmos que utilizan redes neuronales convolucionales. Para implementar el método EP-300, también se presenta una interfaz cerebro-computadora embebida que utiliza cuatro estímulos para evocar el P300 y tiene conectividad con una red de Internet de las cosas. Con esta interfaz, se generó una base de datos para los experimentos y contiene las señales EEG de ocho sujetos. De acuerdo con los resultados, EP-300 se adapta a las señales EEG que genera cada sujeto, tiene un desempeño de 96% utilizando un electrodo y se procesa en tiempo real por su baja complejidad. Sin embargo, para evitar errores en la detección, los sujetos deben mantenerse concentrados y seguir el protocolo de adquisición. Como conclusiones, EP-300 es uno de los métodos más competitivo en la literatura debido a su desempeño, baja cantidad de electrodos y a que extiende el procesamiento de la onda P300 a sistemas ubicuos utilizados en aplicaciones cotidianas.

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“…Recently, meta-analyses have shown that P300 latency is significantly longer in patients with MCI than healthy controls, and even longer in AD patients than MCI patients (Howe, Bani-Fatemi, & De Luca, 2014). Furthermore, longitudinal studies suggested that P300 latency may be a sensitive indicator for early cognitive decline or disease progression in MCI and AD patients (Fruehwirt et al, 2019; Jiang et al, 2015). Taken together, these results provide robust evidence for the use of P300 latency as a biological marker for indicating AD.…”

Section: Introductionmentioning

confidence: 99%

The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment

Gao

Sheng

et al. 2020

Psychol. Med.

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Background Amnestic mild cognitive impairment (aMCI) is characterized by delayed P300 latency and reduced grey matter (GM) volume, respectively. The relationship between the features in aMCI is unclear. This study was to investigate the relationship between the altered P300 latency and the GM volume in aMCI. Methods Thirty-four aMCI and 34 well-matched normal controls (NC) were studied using electroencephalogram during a visual oddball task and scanned with MRI. Both tests were finished in the same day. Results As compared with the NC group, the aMCI group exhibited delayed P300 latency in parietal cortex and reduced GM volumes in bilateral temporal pole and left hippocampus/parahippocampal gyrus. A remarkable negative correlation was found between delayed P300 latency and reduced left hippocampal volume only in the aMCI group. Interestingly, the mediating analysis found P300 latency significantly mediated the association between right supramarginal gyrus volume and information processing speed indicated by Stroop Color and Word Test A scores. Conclusions The association between delayed P300 latency and reduced left hippocampal volume in aMCI subjects suggests that reduced left hippocampal volume may be the potential structural basis of delayed P300 latency.

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Associations of event-related brain potentials and Alzheimer’s disease severity: A longitudinal study

Cited by 29 publications

References 38 publications

Impaired Phasic Discharge of Locus Coeruleus Neurons Based on Persistent High Tonic Discharge—A New Hypothesis With Potential Implications for Neurodegenerative Diseases

Impaired Phasic Discharge of Locus Coeruleus Neurons Based on Persistent High Tonic Discharge—A New Hypothesis With Potential Implications for Neurodegenerative Diseases

Procesamiento embebido de p300 basado en red neuronal convolucional para interfaz cerebro-computadora ubicua

The reduced left hippocampal volume related to the delayed P300 latency in amnestic mild cognitive impairment

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