Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Hsieh, Yi Chen; Hsieh, Fang I.; Chen, Yih Ru; Hu, Chaur Jong; Jeng, Jiann‐Shing; Tang, Sung‐Chun; Fang, Nai; Lin, Huey Juan; Lien, Li Ming; Peng, Giia Sheun; Chiou, Hung Yi

doi:10.1186/s12929-017-0332-1

Cited by 5 publications

(5 citation statements)

References 38 publications

(43 reference statements)

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“…In addition, it is known that oestrogen levels provide protection against inflammation and cardiovascular diseases. While higher oestrogen levels are associated with lower inflammation and a lower probability of ischemic stroke, cognitive functions are also found to be better in these patients [35, 36]. This selection bias may have affected our results.…”

Section: Discussionmentioning

confidence: 95%

Associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, albuminuria and uric acid and the estimated glomerular filtration rate in hypertensive patients with chronic kidney disease stages 1–3

Sevencan

Ozkan

2019

aoms

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IntroductionThe neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), albuminuria and uric acid are known to be independent predictors of hypertension and cardiovascular mortality. However, to date, no study has been conducted describing the relationships between the NLR, PLR and estimated glomerular filtration rate (eGFR) in hypertensive patients with chronic kidney disease (CKD) who do not require renal replacement therapy.Material and methodsThis prospective study included 271 patients with essential hypertension and eGFR ≥ 30 ml/min/1.73 m2. The patients were divided into two groups: those with CKD stages 1 and 2 and those with stage 3. We used the complete blood count to calculate the NLR and PLR, and we measured the albuminuria and uric acid levels. Then, we studied their associations with the eGFR and their potential uses as independent risk factors for renal damage.ResultsThe NLR, albuminuria and uric acid were higher in patients with CKD stage 3 than in those with stages 1 and 2 (p = 0.013, p = 0.001 and p = 0.001, respectively). However, no significant difference was detected in the PLR. In stage 3 patients, albuminuria and uric acid were found to be independent risk factors affecting the eGFR (p = 0.042 and p = 0.001, respectively). However, the effects of the NLR and PLR on the eGFR were not significant (p = 0.104 and p = 0.578, respectively).ConclusionsThe NLR, similar to albuminuria and uric acid, the NLR was found to be a specific marker for CKD stage 3 patients. However, the NLR and PLR did not act as independent risk factors affecting the eGFR.

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Section: Discussionmentioning

confidence: 95%

Associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, albuminuria and uric acid and the estimated glomerular filtration rate in hypertensive patients with chronic kidney disease stages 1–3

Sevencan

Ozkan

2019

aoms

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“…There is emerging evidence of the importance of estrogen as both an antiinflammatory and neuroprotective agent (Hsieh et al , ). Interestingly, a recent study showed that T. foenum‐graecum seed extract significantly decreased serum pro‐inflammatory cytokines (IL‐1, IL‐6 and TNF‐α) and improved metabolic symptoms (including significantly blunting elevated blood glucose levels) in a similar manner to estrogen administration, in ovariectomized rats, a standard experimental model of menopause in rodents (Abedinzade et al , ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Proprietary Trigonella foenum‐graecum L. De‐Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double‐Blind, Randomized, Placebo‐Controlled Study

Steels

Steele

Harold³

et al. 2017

Phytotherapy Research

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Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed). Active treatment was T. foenum-graecum de-husked seed extract, 600 mg per day for 12 weeks. Outcome measures included Menopause-Specific Quality of Life (MENQOL) questionnaire, frequency of hot flushes and night sweats and serum estradiol levels. There was a significant reduction in menopausal symptoms in the active group compared with placebo as assessed by total MENQOL score (p < 0.001); reflected by significant improvements in the vasomotor (p < 0.001), psychosocial (p < 0.001), physical (p < 0.001) and sexual symptoms (p < 0.001) domains. Vasomotor outcomes correlated with hot flushes, the active group reporting significantly less daytime hot flushes and night sweats at 12 weeks (p < 0.001). The average estradiol levels were similar in both the active group and placebo group after treatment. This study demonstrated that this proprietary T. foenum-graecum de-husked seed extract may reduce menopausal symptoms in healthy women. Copyright © 2017 John Wiley & Sons, Ltd.

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“…A case-control and retrospective cohort study was conducted in the GBCS from 30 September 2003 to 13 April 2021. All participants in this study were recruited during the first follow-up period the details of which were reported in an earlier study (16). Briefly, the GBCS, initiated by the Guangzhou Twelfth People's Hospital and the Universities of Hong Kong and Birmingham, is an ongoing prospective cohort to examine genetic, lifestyle, occupational, and environmental factors.…”

Section: Study Design Data Source and Participantsmentioning

confidence: 99%

Genetic loci, rs17817449 and rs6567160, known for obesity and the risk of stroke events among middle-aged and older Chinese people

Zhong

Zhu

2022

Front. Neurol.

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BackgroundFat Mass and Obesity-Associated (FTO) and the Melanocortin-4 Receptor (MC4R) genes are strongly associated with obesity, an established risk factor for stroke. We aimed to assess the associations between rs17817449 at the FTO and rs6567160 at the MC4R and the risk of stroke events in middle-aged and older Chinese people.Materials and methodsStudy data were obtained from the Guangzhou Biobank Cohort Study; a total of 148 participants with a self-reported history of stroke and an equal volume of age- and sex-matched participants were selected as the cases and the controls in a case-control study; a total of 13,967 participants at the first follow-up and all participants with fatal stroke (up to April 2021) were included in a retrospective cohort study. Conditional logistic regression and the Cox proportional hazards regression analyses were used to assess the associations of the two genetic loci with the risk of stroke events.ResultsAfter adjusting for age, sex, education, job, smoking, alcohol consumption, body mass index, physical activity, hypertension, diabetes, and dyslipidemia, rs17817449 and rs6567160 shared minor alleles G and C, respectively, in the case-control analyses. The genotypes GG+GT of rs17817449 at the FTO were significantly associated with a decreased risk of fatal stroke occurrence, with fatal all strokes having an adjusted hazard ratio (aHR) of 0.71 (95% confidence intervals (CI) 0.52-0.97, P = 0.04) and fatal ischemic stroke having an aHR of 0.64 (95% CI 0.41–1.00, P = 0.05), when the genotype TT was taken as a reference and a series of multiplicities were adjusted; the risk of fatal all strokes was lowered by dyslipidemia (aHR = 0.63, 95% CI 0.39–1.00, P = 0.05) and non–diabetes (aHR = 0.68, 95% CI 0.46–0.99, P = 0.049) in the retrospective cohort analyses. Significances were observed neither in the associations between rs6567160 and the risk of stroke events nor in an interaction between rs17817449 and rs6567160 in the two-stage analyses.ConclusionThe G allele of rs17817449 at the FTO, not rs6567160 at the MC4R, was associated with a decreased risk of fatal stroke occurrence; its functional role in stroke should be explored in relatively healthy middle-aged to older Chinese people.

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Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Cited by 5 publications

References 38 publications

Associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, albuminuria and uric acid and the estimated glomerular filtration rate in hypertensive patients with chronic kidney disease stages 1–3

Associations between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, albuminuria and uric acid and the estimated glomerular filtration rate in hypertensive patients with chronic kidney disease stages 1–3

Efficacy of a Proprietary Trigonella foenum‐graecum L. De‐Husked Seed Extract in Reducing Menopausal Symptoms in Otherwise Healthy Women: A Double‐Blind, Randomized, Placebo‐Controlled Study

Genetic loci, rs17817449 and rs6567160, known for obesity and the risk of stroke events among middle-aged and older Chinese people

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