Associations of environmental exposure to dioxins with prevalent diabetes among general inhabitants in Japan

Uemura, Hirokazu; Arisawa, Kokichi; Hiyoshi, Mineyoshi; Satoh, Hiroshi; Sumiyoshi, Yoshio; Morinaga, Kenji; Kodama, Kazunori; Suzuki, Tsuneo; Nagai, Masaki; Suzuki, Tsuguyoshi

doi:10.1016/j.envres.2008.06.002

Cited by 71 publications

(61 citation statements)

References 25 publications

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“…The link between exposure to endocrine disruptor xenobiotics and obesity has already been proposed (Elobeid and Allison, 2008) and some phthalates, which are highly prevalent lipophilic pollutants, have been shown to promote adipocyte differentiation, therefore supporting this hypothesis (Feige et al, 2007). Several epidemiological studies have also linked dioxin exposition to increased risk of diabetes or modified glucose metabolism (Uemura et al, 2008).…”

mentioning

confidence: 59%

Xenobiotic-Metabolizing Cytochromes P450 in Human White Adipose Tissue: Expression and Induction

Ellero

Chakhtoura²,

Barreau³

et al. 2009

Drug Metab Dispos

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ABSTRACT:Lipophilic pollutants can accumulate in human white adipose tissue (WAT), and the consequences of this accumulation are still poorly understood. Cytochromes P450 (P450s) have recently been found in rat WAT and shown to be inducible through mechanisms similar to those in the liver. The aim of our study was to describe the cytochrome P450 pattern and their induction mechanisms in human WAT. Explants of subcutaneous and visceral WAT and primary culture of subcutaneous adipocytes were used as WAT models, and liver biopsies and primary culture of hepatocytes were used as liver models to characterize P450 expression in both tissues. The WAT and liver models were then treated with typical P450 inducers (rifampicin, phenobarbital, and 2,3,7,8-tetrachlorodibenzo-p-dioxin) and lipophilic pollutants (lindane, prochloraz, and chlorpyrifos), and the effects on P450 expression were studied. P450 expression was considerably lower in WAT than in the liver, except for CYP1B1 and CYP2U1, which were the most highly expressed adipose P450s in all individuals. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and prochloraz induced CYP1A1 and CYP1B1 expression in both tissues. The aryl hydrocarbon receptor was also present in WAT. In contrast, neither phenobarbital nor rifampicin treatment induced CYP2 or CYP3 mRNA in WAT, and constitutive androstane receptor and pregnane X receptor were almost undetectable. These results suggest that the mechanisms by which P450s of family 1 are regulated in the liver are also functional in human WAT, but those regulating CYP2 and CYP3 expression are not.

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mentioning

confidence: 59%

Xenobiotic-Metabolizing Cytochromes P450 in Human White Adipose Tissue: Expression and Induction

Ellero

Chakhtoura²,

Barreau³

et al. 2009

Drug Metab Dispos

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“…Recent studies have measured more PCB congeners in detail; however, analyses were performed using the accumulated TEQs [13] or the total/subtotal sum of PCB congeners [14,25], and differences in the specific effects of PCB congeners have rarely been reported. Knowledge from experimental studies is also insufficient.…”

Section: Discussionmentioning

confidence: 99%

“…PCB 126, along with polychlorinated dibenzo-p-dioxin and p,p'-DDT, was considered in a general population in the USA, and a significant association was found with diagnosed diabetes and undiagnosed diabetes, which was defined as an HbA1c level > 6.1% [12]. Among the general population of Japan, a cross-sectional study measured seven polychlorinated dibenzo-p-dioxins (PCDDs), ten polychlorinated dibenzofurans (PCDFs) and 12 dioxin-like PCBs and showed that the accumulated toxic equivalents (TEQs) of these compounds were positively correlated with the HbA1c level [13]. In addition, the prevalence of diabetes, as defined by the self-reporting of physician-diagnosed diabetes or an HbA1c level > 6.5%, was positively associated with the accumulated TEQs of dioxin-like PCBs [13].…”

Section: Study Populationmentioning

confidence: 99%

“…Among the general population of Japan, a cross-sectional study measured seven polychlorinated dibenzo-p-dioxins (PCDDs), ten polychlorinated dibenzofurans (PCDFs) and 12 dioxin-like PCBs and showed that the accumulated toxic equivalents (TEQs) of these compounds were positively correlated with the HbA1c level [13]. In addition, the prevalence of diabetes, as defined by the self-reporting of physician-diagnosed diabetes or an HbA1c level > 6.5%, was positively associated with the accumulated TEQs of dioxin-like PCBs [13].…”

Section: Study Populationmentioning

confidence: 99%

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Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)

et al. 2011

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“…Consequently, it is not unlikely that POPs, which mainly accumulate in fat tissues, contribute to the production and release of inflammation-related adipose tissue proteins known to be involved in the development of chronic metabolic disorders such as T2DM. A number of studies have found associations between T2DM and POPs, such as polychlorinated biphenyls, [74][75][76][77][78] polychlorinated dibenzo-p-dioxins [75][76][77]79 and organochlorine pesticides, [74][75]77,[80][81][82] which are usually detectable at low levels in humans. The previous observations arise from crosssectional studies, making it difficult to establish a causeeffect relationship.…”

Section: Risksmentioning

confidence: 99%

Obesity and type 2 diabetes in Northern Canada's remote First Nations communities: the dietary dilemma

et al. 2010

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First Nations populations in Northwestern Ontario have undergone profound dietary and lifestyle transformations in less than 50 years, which have contributed to the alarming rise in obesity and obesity-related diseases, in particular type 2 diabetes mellitus. Even though the genetic background of First Nations peoples differs from that of the Caucasians, genetics alone cannot explain such a high prevalence in obesity and type 2 diabetes. Modifications in lifestyle and diet are major contributors for the high prevalence of chronic diseases. What remains constant in the literature is the persistent view that locally harvested and prepared foods are of tremendous value to First Nations peoples providing important health and cultural benefits that are increasingly being undermined by westernbased food habits. However, the complexities of maintaining a traditional diet require a multifaceted approach, which acknowledges the relationship between benefits, risks and viability that cannot be achieved using purely conventional medical and biological approaches. This brief review explores the biological predispositions and potential environmental factors that contribute to the development of the high incidence of obesity and obesity-related diseases in First Nations communities in Northern Canada. It also highlights some of the complexities of establishing exact physiological causes and providing effective solutions.

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Associations of environmental exposure to dioxins with prevalent diabetes among general inhabitants in Japan

Cited by 71 publications

References 25 publications

Xenobiotic-Metabolizing Cytochromes P450 in Human White Adipose Tissue: Expression and Induction

Xenobiotic-Metabolizing Cytochromes P450 in Human White Adipose Tissue: Expression and Induction

Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)

Obesity and type 2 diabetes in Northern Canada's remote First Nations communities: the dietary dilemma

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