Associations of Dynapenic Obesity and Sarcopenic Obesity with the Risk of Complications in COVID-19

Mayoral, Eduardo Pérez-Campos; Matías-Cervantes, Carlos Alberto; Pérez-Campos, Eduardo; Díaz, Carlos Romero; Barrios, Luis Ángel Laguna; Canseco, María del Socorro Pina; Cruz, Margarito Martínez; Mayoral, Eduardo Pérez-Campos; Mata, Carlos Josué Solórzano; Canales, Francisco Javier Rodal; Ruíz, Héctor Martínez; Hernández-Huerta, María Teresa

doi:10.3390/ijms23158277

Cited by 7 publications

(8 citation statements)

References 123 publications

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“…Furthermore, a review of elderly patients to determine the association between elderly obesity and COVID-19 prognosis detected that dynapenic or sarcopenic obesity could be connected to poor prognosis and a higher risk of COVID-19 complications [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Body Mass Index and Clinical Outcomes in Adult COVID-19 Patients of Diverse Ethnicities

et al. 2022

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(1) Background: Body mass index (BMI) was observed to affect COVID-19 outcomes; however, the complete spectrum of clinical outcomes concerning BMI remains unexplored. The current study aimed to investigate the correlation between BMI and the severity and mortality of COVID-19, as well as ICU admission, radiological findings, clinical presentation, and time to viral clearance. (2) Methods: This retrospective study included 1796 multiethnic patients with COVID-19 treated at NMC Royal Hospital, Abu Dhabi, UAE. (3) Results: COVID-19’s adjusted odds of severity increased by 3.7- and 21.5-fold in classes I and III, respectively (p = 0.001). The odds of mortality were not significantly different after adjustment for age, sex, and race. The adjusted odds of ICU admission increased significantly by 3-fold and non-significantly by 4-fold in obesity classes I and II, respectively. Pneumonia was significantly higher in patients who were overweight and class I, II, and III obese. Furthermore, class III obese patients had a greater risk of presenting with combined respiratory and gastrointestinal manifestations (p < 0.001). The median time to viral clearance with a BMI > 40 kg/m2 was moderately higher than that with a BMI < 40 kg/m2. (4) Conclusions: High BMI was associated with pneumonia, ICU admission, severity, and mortality due to COVID-19.

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Section: Discussionmentioning

confidence: 99%

Body Mass Index and Clinical Outcomes in Adult COVID-19 Patients of Diverse Ethnicities

et al. 2022

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“…The presence of DO can be even more harmful to the health of older adults; this is confirmed by studies that show that DO affects more than obesity or dynapenia alone; several variables such as physical performance [8], increased risk of falls [23], mortality, hospitalization, and disability [24]. In the oldest old patients, there is difficulty in diagnosing DO because often, the term DO is not known and little explored [7]. Thus, patients with low handgrip strength may be an indication that should be considered [7].…”

Section: Introductionmentioning

confidence: 95%

“…This accumulation of body fat can lead to obesity, an inflammatory disease with an increased risk for chronic diseases, including type 2 diabetes, hypertension, coronary heart disease, heart disease, and osteoarthritis [3]. Also, the decrease in lean mass, which is associated with several factors such as changes in the nervous system, the size and percentage of type II fibers [4], and fat infiltration into the muscle [5,6] contribute to lower muscle strength (dynapenia) [7][8][9] and sarcopenia [10]. Both obesity and dynapenia negatively affect the health and physical performance of older adults [3], and the coexistence of these two factors is called dynapenic obesity (OD) [11].…”

Section: Introductionmentioning

confidence: 99%

“…In the oldest old patients, there is difficulty in diagnosing DO because often, the term DO is not known and little explored [7]. Thus, patients with low handgrip strength may be an indication that should be considered [7]. Moreover, deficits in the structure and function of the intrinsic force-generating properties of skeletal muscle are potential antecedents of dynapenia [7].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, patients with low handgrip strength may be an indication that should be considered [7]. Moreover, deficits in the structure and function of the intrinsic force-generating properties of skeletal muscle are potential antecedents of dynapenia [7]. Thus, screening to clarify this decline becomes an essential geriatric clinical parameter [8] Furthermore, studies showed an association between a pro-inflammatory condition and DO in the youngest-old and middle-old [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Influence of dynapenic obesity on inflammation and muscle quality in oldest-old patients

Rosa,

Garcia,

Sousa Neto

et al. 2024

Rev Bras Fisiol Exerc

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Introduction: Aging is associated with a decrease in strength (dynapenia) and an increase in body fat. Both obesity and dynapenia negatively influence health in the oldest old. When these two variables coexist, called dynapenic obesity (DO), these further harms the older adult's health. Objective: To verify the influence of dynapenic obesity on inflammation, physical performance, and muscle quality in the oldest old with and without DO. Methods: Forty-six oldest old participants were included in this study, and sociodemographic, muscle strength, body composition, physical performance, and cytokine data were collected. The sample was divided into DO and control groups to compare the variables. Results: The DO group had higher levels of inflammation, lower levels of absolute handgrip strength, and field muscle quality index than the control group, but with no difference in physical performance or laboratory muscle quality index. Conclusion: Therefore, this study points to dynapenic obesity as an important variable that should be evaluated and considered in the oldest old to prevent possible adverse outcomes in this population.

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Sleep duration affects the sequential change of body mass index and muscle strength: a contribution to dynapenic obesity

Zhang

Wang

et al. 2023

BMC Geriatr

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Background With aging, body mass index (BMI) increases and muscle strength declines, resulting in dynapenic obesity. It remains unknown whether and how sleep duration contributes to the sequence of BMI and muscle strength change in the progression of dynapenic obesity. Methods Data were derived from the first two waves of China Health and Retirement Longitudinal Study. Sleep duration was self-reported. BMI was calculated and grip strength (GS) was measured to reflect muscle strength. The effect of baseline sleep duration on the sequential change of BMI and GS was assessed using two mediation models considering the nonlinear associations between them. The moderating effect of metabolic disorder was also tested. Results Totally 4986 participants aged ≥ 50 years (50.8% females) with complete information on variables were included. Baseline BMI fully mediated the nonlinear association between sleep duration and follow-up GS change, but baseline GS did not mediate between sleep duration and follow-up BMI change for older men and women. Short sleep duration positively affected BMI-induced GS change (β = 0.038; 95%CI, 0.015–0.074), while this favorable effect became nonsignificant for moderate sleep duration (β = 0.008; 95% CI, -0.003–0.024) and turned negative with prolonged sleep duration (β = − 0.022; 95%CI, − 0.051 to − 0.003). This nonlinear mediation effect was more pronounced in older women who are relatively metabolically healthy at baseline. Conclusion For older adults in China, the influence of sleep duration on BMI-induced GS change but not the GS-induced BMI change suggested the contribution of sleep duration to the sequential course in the progression of dynapenic obesity. Sleep duration deviated either above or below normal range may confer adverse impact on GS through BMI. Strategies addressing sleep and obesity jointly to improve muscle function and delay the progression of dynapenic obesity are required.

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Associations of Dynapenic Obesity and Sarcopenic Obesity with the Risk of Complications in COVID-19

Cited by 7 publications

References 123 publications

Body Mass Index and Clinical Outcomes in Adult COVID-19 Patients of Diverse Ethnicities

Body Mass Index and Clinical Outcomes in Adult COVID-19 Patients of Diverse Ethnicities

Influence of dynapenic obesity on inflammation and muscle quality in oldest-old patients

Sleep duration affects the sequential change of body mass index and muscle strength: a contribution to dynapenic obesity

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