Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey

Quansah, Dan Yedu; Ha, Kyungho; Jun, Shinyoung; Kim, Seong-Ah; Shin, Sangah; Wie, Gyung-Ah; Joung, Hyojee

doi:10.3390/molecules22101664

Cited by 18 publications

(21 citation statements)

References 46 publications

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“…Evidence has it that low dietary intake of antioxidants such as β-carotene, α-tocopherol, and vitamin E play independent roles in the pathogenesis of Type 2 diabetes by increasing insulin resistance or impairing insulin action. Intake of diets with sufficient antioxidants, commonly fruits and vegetables, ensure a balanced defense mechanism on harmful effects of reactive oxygen species as they could prevent the gradual impairing of pancreatic β-cell, therefore reducing the risk of Type 2 diabetes (30, 31).…”

Section: The Role Of Non-genetic Factors On Type 2 Diabetesmentioning

confidence: 99%

The Play of Genes and Non-genetic Factors on Type 2 Diabetes

Mambiya

Shang

Wang

et al. 2019

Front. Public Health

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Diabetes has been a disease of public health concern for a number of decades. It was in the 1930s when scientists made an interesting discovery that the disease is actually divided into two types as some patients were insensitive to insulin treatment then. Type 2 Diabetes which happens to be the non-insulin dependent one is the most common form of the disease and is caused by the interaction between genetic and non-genetic factors. Despite conflicting results, numerous studies have identified genetic and non-genetic factors associated with this common type of diabetes. This review has summarized literature on some genes and non-genetic factors which have been identified to be associated with Type 2 diabetes. It has sourced literature from PubMed, Web of Science and Medline without any limitation to regions, publication types, or languages. The paper has started with the introduction, the play of non-genetic factors, the impact of genes in general, and ended with the interaction between some genes and environmental factors.

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Section: The Role Of Non-genetic Factors On Type 2 Diabetesmentioning

confidence: 99%

The Play of Genes and Non-genetic Factors on Type 2 Diabetes

Mambiya

Shang

Wang

et al. 2019

Front. Public Health

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“…Dietary carotenoids have also been shown to be associated with the incidence of type 2 diabetes. Quansah et al observed that increased intake of α-carotene had a 48% and 39% reduction in diabetes risk in Korean men and women, respectively [ 44 ]. Additionally, β-carotene intake also reduced the risk of diabetes in men (though no association was found in women) [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis

et al. 2022

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Vitamins have many established roles in human health. However, the role of habitual dietary intake of vitamins in glucose homeostasis in individuals after acute pancreatitis (AP) is yet to be elucidated. The aim was to investigate the associations between habitual intake of fat- and water-soluble vitamins/vitamers and markers of glucose metabolism (fasting plasma glucose (FPG), homeostasis model assessment insulin resistance (HOMA-IR) index, and homeostasis model assessment β-cell function (HOMA-β)) in individuals after AP. A total of 106 participants after AP were included in this cross-sectional study and were grouped based on glycaemic status: new-onset prediabetes/diabetes after AP (NODAP), pre-existing prediabetes/type 2 diabetes (T2DM), and normoglycaemia after AP (NAP). Habitual intake of seven fat-soluble vitamins/vitamers and seven water-soluble vitamins were determined by the EPIC-Norfolk food frequency questionnaire. Multiple linear regression analyses were conducted using five statistical models built to adjust for covariates (age, sex, daily energy intake, visceral/subcutaneous fat volume ratio, smoking status, daily alcohol intake, aetiology of AP, number of AP episodes, cholecystectomy, and use of antidiabetic medications). In the NODAP group, three fat-soluble vitamins/vitamers (α-carotene, β-carotene, and total carotene) were significantly associated with HOMA-β. One water-soluble vitamin (vitamin B3) was also significantly associated with HOMA-β in the NODAP group. None of the studied vitamins were significantly associated with FPG or HOMA-IR in the NODAP group. Prospective longitudinal studies and randomised controlled trials are now warranted to investigate if the observed associations between vitamin/vitamer intake and NODAP are causal and to unveil the specific mechanisms underlying their involvement with NODAP.

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“…Antioxidants such as β-carotene are suggested to decrease risk of type 2 diabetes by preventing progressive impairment of pancreatic β-cell and endothelial function. A study was conducted to investigate the relationship between dietary antioxidants and risk of type 2 diabetes in 24,377 adults (19-74 years old) [56]. Men in the highest quartile of β-carotene intake showed lower risk of type 2 diabetes.…”

Section: Role Of β-Carotene (Vitamin A) In Hot Pepper In Disease Therapymentioning

confidence: 99%

Capsaicinoids and Vitamins in Hot Pepper and Their Role in Disease Therapy

Antonįous¹

2018

Capsaicin and Its Human Therapeutic Development

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Members of the genus Capsicum (Family: Solanaceae), which belongs to a dicotyledonous group of flowering plants, show fluctuating degrees of spiciness that mirror the relative concentrations of capsaicin, dihydrocapsaicin, and other analogs (nordihydrocapsaicin, homocapsaicin, and homodihydrocapsaicin) collectively known as capsaicinoids present in the fruit placenta. Pungent Chili varieties are grown for their food value, healthpromoting properties and as a source of capsaicinoids that have a variety of medicinal uses. Accessions of the cultivated species (Capsicum annuum, C. baccatum, C. chinense, C. frutescens, and C. pubescens) have not all been analyzed for their capsaicinoids content. Identifying Capsicum species and accessions (genotypes) within species with high levels of antioxidants and bioactive compounds (capsaicin, dihydrocapsaicin, vitamin C, vitamin E, phenols, and β-carotene) that contribute to human disease therapy is the focus of this investigation. The main objectives of this chapter are to compile an overview of most recent achievements of the pharmacological properties of hot pepper compounds and provide a rationale for their use as analgesics and to present an evidence that supports the use of capsaicinoids in the treatment of neuropathic pain and other top leading death of worldwide human diseases.

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Associations of Dietary Antioxidants and Risk of Type 2 Diabetes: Data from the 2007–2012 Korea National Health and Nutrition Examination Survey

Cited by 18 publications

References 46 publications

The Play of Genes and Non-genetic Factors on Type 2 Diabetes

The Play of Genes and Non-genetic Factors on Type 2 Diabetes

Relationship between Habitual Intake of Vitamins and New-Onset Prediabetes/Diabetes after Acute Pancreatitis

Capsaicinoids and Vitamins in Hot Pepper and Their Role in Disease Therapy

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