Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults

Sun, Jichao; Xu, Ming; Lü, Jie; Bi, Yan; Mu, Yiming; Zhao, Jiajun; Liu, C; Chen, L L; Shi, Lixin; Li, Q; Yang, Tao; Yan, Li; Wan, Qin; Wu, Shengli; Liu, Y; Wang, G X; Luo, Zuojie; Tang, Xulei; Chen, G; Huo, Yanan; Gao, Zhengnan; Su, Qing; Ye, Z; Wang, Y M; Qin, Guijun; Deng, Hongkui; Yu, Xuefeng; Shen, Feixia; Chen, L; Zhao, Liebin; Wang, T G; Lai, Shenghan; Li, D H; Wang, W Q; Ning, Guang

doi:10.1111/dme.12649

Cited by 38 publications

(35 citation statements)

References 31 publications

(57 reference statements)

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“…In a large cross-sectional Chinese study, only people with previously known diabetes showed elevated depressive symptoms and more people treated with insulin showed elevated depressive symptoms, compared with those taking oral or no antidiabetes medication [8]. In contrast, we did not observe such a robust association between use of antidiabetes medication and depressive symptoms among people with diagnosed diabetes.…”

Section: Discussioncontrasting

confidence: 96%

Glycaemic status and depressive symptoms among adults in Germany: results from the German Health Interview and Examination Survey for Adults (DEGS1)

et al. 2018

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Section: Discussioncontrasting

confidence: 96%

Glycaemic status and depressive symptoms among adults in Germany: results from the German Health Interview and Examination Survey for Adults (DEGS1)

et al. 2018

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“…The highest prevalence was based on the BDI, cut-off ≥ 10 (n = 17 participants) [29]. The lowest prevalence was based on the PHQ-9, cut-off ≥ 10 (n = 229 047) [30] and in a separate study by the BDI-II, cut-off ≥ 20 (n = 5145) [31].…”

Section: Resultsmentioning

confidence: 99%

Depression prevalence in Type 2 diabetes is not related to diabetes–depression symptom overlap but is related to symptom dimensions within patient self‐report measures: a meta‐analysis

et al. 2019

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Aim Depression is common in Type 2 diabetes, yet rates vary. Overlap between symptoms of depression and diabetes may account for this variability in depression prevalence rates. We examined to what extent depression prevalence was a function of the proportion of depression–diabetes symptom overlap (items within symptom dimensions) and sample characteristics. Methods Electronic and hand searching of published and unpublished works identified 147 eligible papers. Of 3656 screened, 147 studies (149 samples, N = 17–229 047, mean sample age 25.4–82.8 years, with 152 prevalence estimates), using 24 validated depression questionnaires were selected. Sample size, publication type, sample type, gender, age, BMI, HbA1c, depression questionnaire and prevalence rates were extracted. Results Prevalence rates ranged from 1.8% to 88% (mean = 28.30%) and were higher in younger samples, samples with higher mean HbA1c and clinic samples. Diabetes–depression symptom overlap did not affect prevalence. A higher proportion of anhedonia, cognition, cognitive, negative affect and sleep disturbance symptoms, and a lower proportion of somatic symptoms were consistently associated with higher depression prevalence. Conclusions The lack of an overall effect of diabetes–depression symptom overlap might suggest that assessment of depression in Type 2 diabetes is generally not confounded by co‐occuring symptoms. However, questionnaires with proportionally more or fewer items measuring other symptom categories were associated with higher estimates of depression prevalence. Depression measures that focus on the cardinal symptoms of depression (e.g. negative affect and cognition), limiting symptoms associated with increasing diabetes symptomatology (e.g. sleep disturbance, cognitive) may most accurately diagnose depression.

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“…The paper also reported that the odds of depression were not higher in individuals with screening diagnosed type 2 diabetes or impaired glucose metabolism (pre-diabetes) compared with those with normal glucose metabolism [13]. A Chinese study also concluded that, compared with people with normal glucose regulation (n = 120 458), people with diabetes (n = 24 251) had higher odds of probable diagnosis of depression (1.61, 95% CI 1.39-1.87) and sub-threshold depression [odds ratio (OR) = 1.14, 95% CI 1.06-1.24], whereas newly diagnosed diabetes (n = 24 826) or impaired glucose regulation (n = 59 512) were not associated with depression [16].…”

Section: The Prevalence Of Depression In Diabetesmentioning

confidence: 99%

How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes

et al. 2020

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This narrative review of the literature provides a summary and discussion of 25 years of research into the complex links between depression and diabetes. Systematic reviews have shown that depression occurs more frequently in people with type 1 or type 2 diabetes compared with people without diabetes. Currently, it remains unclear whether depression is also more common in people with impaired glucose metabolism or undiagnosed type 2 diabetes compared with people without diabetes. More prospective epidemiological research into the course of depression and an exploration of mechanisms in individuals with diabetes are needed. Depression in diabetes is associated with less optimal self‐care behaviours, suboptimal glycaemic control, impaired quality of life, incident micro‐ and macrovascular diseases, and elevated mortality rates. Randomized controlled trails concluded that depression in diabetes can be treated with antidepressant medication, cognitive–behavioural therapy (individual, group‐based or web‐based), mindfulness‐based cognitive therapy and stepped care. Although big strides forward have been made in the past 25 years, scientific evidence about depression in diabetes remains incomplete. Future studies should investigate mechanisms that link both conditions and test new diabetes‐specific web‐ or app‐based interventions for depression in diabetes. It is important to determine whether treatment or prevention of depression prevents future diabetes complications and lowers mortality rates.

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Associations of depression with impaired glucose regulation, newly diagnosed diabetes and previously diagnosed diabetes in Chinese adults

Cited by 38 publications

References 31 publications

Glycaemic status and depressive symptoms among adults in Germany: results from the German Health Interview and Examination Survey for Adults (DEGS1)

Glycaemic status and depressive symptoms among adults in Germany: results from the German Health Interview and Examination Survey for Adults (DEGS1)

Depression prevalence in Type 2 diabetes is not related to diabetes–depression symptom overlap but is related to symptom dimensions within patient self‐report measures: a meta‐analysis

How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes

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