Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population

Abstract

The ADRA2B gene 301–303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27–65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index (P = 0.014), ejection duration (P = 0.045), and lower SEVR (P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men (n = 33) whereas in women (n = 30) the differences were suggestive (P < 0.1). It is concluded that in a northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, and impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers.

Adrenoceptor Desensitization: Current Understanding of Mechanisms

“…Co-expression of this variant with GRK2 in COS-7 cells resulted in a significantly decreased GRK-mediated phosphorylation and a complete attenuation of short-term desensitization (Small et al, 2001) the deletion variant demonstrated a significantly increased risk of acute coronary events, described as prolonged chest pain or acute myocardial infarction (Snapir et al, 2001). However, more recently, a study in a northern Russian population determined that men with homozygous insertion genotype have stiffer arteries, shorter diastole duration and impaired coronary perfusion than deletion homozygotes (Melnikov et al, 2018). It is clear that additional investigations with larger sample sizes are warranted to determine the clinical significance of these findings.…”