Associations of Cord Blood Lipids with Childhood Adiposity at the Age of Three Years: A Prospective Birth Cohort Study

Ye, Qi-Qing; Kong, Shao-Min; Yin, Xin; Gao, Chang; Lu, Min‐Shan; Ramakrishnan, Rema; Guo, Cheng; Yao, Wang; Zeng, Ji-Yuan; Kuang, Yashu; Lu, Jinhua; He, Jian; Qiu, Xiu

doi:10.3390/metabo12060522

Cited by 2 publications

(4 citation statements)

References 38 publications

(43 reference statements)

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“…Our results further discovered inverse correlations between cord serum TG concentrations, TG/TC ratios and weight Z-scores and BMI Z-scores up to 18 months. These outcomes were in accordance with research work from Ye et al (19) and Cao et al (20). It has been shown that hypertriglyceridemia was closely related to islet b-cell dysfunctions, including interfered b-cell maturation, suppressed b-cell proliferation, inhibited insulin secretion, and induced insulin resistance.…”

Section: Discussionsupporting

confidence: 91%

“…It has been demonstrated that cord plasma TG levels were positively associated with adiposity indicators among SGA infants but tended to be negatively associated with adiposity indicators among LGA infants in the research of Ye et al. ( 19 ). However, our outcomes did not find such opposite associations between TG levels and weight Z-scores or BMI Z-scores stratified by weight for gestational age, even after adjusting for confounding variables.…”

Section: Discussionmentioning

confidence: 95%

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Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity

et al. 2023

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ObjectiveThis prospective cohort study was aimed at investigating the associations between cord blood metabolic factors and early-childhood growth, further elucidating the relationships between cord blood metabolites and overweight and obesity in early life.MethodsA total of 2,267 pairs of mothers and offspring were recruited in our study. Cord blood plasma was assayed for triglycerides (TGs), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), C-peptide, insulin, and glycosylated hemoglobin type A1C (HbA1c) levels. Data of anthropometric measurements were collected from offspring at birth, 6 months, 12 months, and 18 months. Multiple linear regression models were used to evaluate the correlations between cord blood metabolic factors and weight Z-scores, body mass index (BMI) Z-scores, and weight gains at the early stage of life. Forward stepwise logistic regression analyses were applied to explore the associations between cord blood metabolic factors and early-childhood overweight and obesity. Receiver operating characteristic (ROC) curve analyses were applied to determine the optimal cutoff points for cord blood metabolic factors in predicting early-childhood overweight and obesity.ResultsAfter adjustments for covariates, cord blood TG concentrations and TG/TC ratios were negatively associated with weight Z-scores from birth to 18 months. Cord blood C-peptide and HbA1c levels were inversely associated with weight Z-scores at 6 months and 18 months. Cord blood TG concentrations and TG/TC ratios were negatively correlated with BMI Z-scores up to 18 months. Cord blood C-peptide levels and HbA1c levels were inversely correlated with BMI Z-scores at 18 months. Cord blood TG, TG/TC ratios, C-peptide, and HbA1c had negative correlations with weight gains from birth to 6 months, but the correlations attenuated as time went on. Increase in cord blood TG and HbA1c levels and TG/TC ratios were significantly associated with decreased risks of overweight and obesity at 6 months, 12 months, and 18 months.ConclusionsCord blood metabolic factors were significantly associated with early-childhood growth patterns.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity

et al. 2023

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“…As proposed by Ye et al. ( 48 ), this potential interaction between lipid particles in the fetus could be critical for the fetal and neonatal metabolism, and may have a lasting impact on the metabolic health of the offspring. Cord blood markers including insulin, C-peptide and HOMA-IR were related to birth anthropometry in univariate, but not in multivariate analyses.…”

Section: Discussionmentioning

confidence: 89%

“…The findings of two previous studies in GDM showing inverse correlations between cord blood triglyceride and birth anthropometry further underline our results ( 19 , 28 ). Large molecules such as HDL cannot cross the placenta directly, but they could affect the metabolism of other lipids, depending on the concentration and presence ( 47 , 48 ). As proposed by Ye et al.…”

Section: Discussionmentioning

confidence: 99%

Maternal and fetal predictors of anthropometry in the first year of life in offspring of women with GDM

et al. 2023

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IntroductionGestational Diabetes Mellitus (GDM) carries an increased risk for adverse perinatal and longer-term cardiometabolic consequences in offspring. This study evaluated the utility of maternal anthropometric, metabolic and fetal (cord blood) parameters to predict offspring anthropometry up to 1 year in pregnancies with GDM.Materials and methodsIn this prospective analysis of the MySweetheart study, we included 193/211 women with GDM that were followed up to 1 year postpartum. Maternal predictors included anthropometric (pre-pregnancy BMI, gestational weight gain (GWG), weight and fat mass at the 1st GDM visit), and metabolic parameters (fasting insulin and glucose, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Quantitative insulin-sensitivity check index (QUICKI), HbA1c, triglycerides, and high-density lipoprotein (HDL) at the 1st visit and HbA1c at the end of pregnancy). Fetal predictors (N=46) comprised cord blood glucose and insulin, C-Peptide, HOMA-IR, triglycerides and HDL. Offspring outcomes were anthropometry at birth (weight/weight z-score, BMI, small and large for gestational age (SGA,LGA)), 6-8 weeks and 1 year (weight z-score, BMI/BMI z-score, and the sum of 4 skinfolds).ResultsIn multivariate analyses, birth anthropometry (weight, weight z-score, BMI and/or LGA), was positively associated with cord blood HDL and HbA1c at the 1st GDM visit, and negatively with maternal QUICKI and HDL at the 1st GDM visit (all p ≤ 0.045). At 6-8 weeks, offspring BMI was positively associated with GWG and cord blood insulin, whereas the sum of skinfolds was negatively associated with HDL at the 1st GDM visit (all p ≤0.023). At 1 year, weight z-score, BMI, BMI z-score, and/or the sum of skinfolds were positively associated with pre-pregnancy BMI, maternal weight, and fat mass at the 1st GDM visit and 3rd trimester HbA1c (all p ≤ 0.043). BMI z-score and/or the sum of skinfolds were negatively associated with cord blood C-peptide, insulin and HOMA-IR (all p ≤0.041).DiscussionMaternal anthropometric, metabolic, and fetal metabolic parameters independently affected offspring anthropometry during the 1st year of life in an age-dependent manner. These results show the complexity of pathophysiological mechanism for the developing offspring and could represent a base for future personalized follow-up of women with GDM and their offspring.

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Associations of Cord Blood Lipids with Childhood Adiposity at the Age of Three Years: A Prospective Birth Cohort Study

Cited by 2 publications

References 38 publications

Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity

Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity

Maternal and fetal predictors of anthropometry in the first year of life in offspring of women with GDM

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